| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.05 | +0.05 | buy |
| VR Adviser, LLC | 924,170 | 2,575,593 | +1,651,423 | 0.38 | 0.93 | +0.55 | buy |
| Woodline Partners LP | 0 | 599,975 | +599,975 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 864,332 | 1,071,460 | +207,128 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 625,056 | 754,885 | +129,829 | 0.45 | 0.56 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,420 | 132,606 | +116,186 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162,860 | 259,416 | +96,556 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 28,254 | 112,634 | +84,380 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 78,251 | +78,251 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 69,869 | +69,869 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 263,349 | 325,995 | +62,646 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 67,677 | 124,443 | +56,766 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 3,282 | 55,449 | +52,167 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 50,700 | +50,700 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 42,424 | +42,424 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 41,713 | +41,713 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 38,003 | +38,003 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 33,170 | +33,170 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 32,817 | +32,817 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 29,630 | +29,630 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 29,045 | +29,045 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 28,795 | +28,795 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 308,690 | 336,458 | +27,768 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 125,954 | 144,678 | +18,724 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 16,737 | +16,737 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 234,003 | 249,939 | +15,936 | 0.03 | 0.04 | +0.02 | buy |
| Walleye Capital LLC | 0 | 15,006 | +15,006 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 95,080 | 109,180 | +14,100 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 13,063 | +13,063 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,765 | +12,765 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,848,564 | 2,861,255 | +12,691 | 0.01 | 0.02 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,279 | +12,279 | 0.00 | 0.01 | +0.01 | buy |
| Heritage Wealth Management, Inc./Texas | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 57,009 | 61,549 | +4,540 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 84 | 1,169 | +1,085 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 141,800 | 141,800 | 0 | 0.01 | 0.02 | +0.00 | hold |
| RHUMBLINE ADVISERS | 296 | 296 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 12,757,562 | 12,757,562 | 0 | 1.68 | 1.49 | -0.18 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 31,900 | 31,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 18,621 | 18,621 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 301,533 | 301,533 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 4,050,218 | 4,050,218 | 0 | 2.01 | 2.12 | +0.12 | hold |
| PURA VIDA INVESTMENTS, LLC | 1,413,242 | 1,413,242 | 0 | 2.71 | 1.77 | -0.95 | hold |
| Clearline Capital LP | 119,128 | 119,128 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Samsara BioCapital, LLC | 2,780,261 | 2,780,261 | 0 | 3.33 | 2.27 | -1.06 | hold |
| Ikarian Capital, LLC | 1,254,384 | 1,254,384 | 0 | 1.82 | 1.80 | -0.02 | hold |
| COMERICA BANK | 1,159 | 1,159 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| Ameliora Wealth Management Ltd. | 750 | 0 | -750 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,762 | 2,362 | -4,400 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 49,800 | 43,900 | -5,900 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 19,618 | 0 | -19,618 | 0.01 | 0.00 | -0.01 | sell |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 30,000 | 0 | -30,000 | 0.03 | 0.00 | -0.03 | sell |
| Alyeska Investment Group, L.P. | 130,839 | 0 | -130,839 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 1,550,000 | 1,088,000 | -462,000 | 0.18 | 0.15 | -0.03 | sell |
| Soleus Capital Management, L.P. | 592,417 | 0 | -592,417 | 0.23 | 0.00 | -0.23 | sell |