| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 4,092,731 | 6,249,731 | +2,157,000 | 3.44 | 3.53 | +0.09 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,684,005 | 4,192,005 | +1,508,000 | 1.50 | 2.10 | +0.59 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,440,345 | 4,125,345 | +685,000 | 3.89 | 5.09 | +1.20 | buy |
| Frazier Life Sciences Management, L.P. | 3,622,294 | 3,687,867 | +65,573 | 2.37 | 1.85 | -0.53 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 705,000 | 2,575,000 | +1,870,000 | 0.02 | 0.06 | +0.04 | buy |
| VANGUARD GROUP INC | 1,781,419 | 1,685,113 | -96,306 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 0 | 1,464,606 | +1,464,606 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 1,807,563 | 1,441,952 | -365,611 | 8.48 | 6.86 | -1.62 | sell |
| First Turn Management, LLC | 0 | 1,179,420 | +1,179,420 | 0.00 | 2.09 | +2.09 | buy |
| TCG Crossover Management, LLC | 3,395,495 | 1,163,356 | -2,232,139 | 4.61 | 1.09 | -3.52 | sell |
| STEMPOINT CAPITAL LP | 423,174 | 1,161,060 | +737,886 | 1.40 | 3.68 | +2.28 | buy |
| DAFNA Capital Management LLC | 601,032 | 806,973 | +205,941 | 1.76 | 2.18 | +0.41 | buy |
| MPM BioImpact LLC | 0 | 760,722 | +760,722 | 0.00 | 1.45 | +1.45 | buy |
| EMERALD ADVISERS, LLC | 0 | 671,176 | +671,176 | 0.00 | 0.32 | +0.32 | buy |
| Vestal Point Capital, LP | 0 | 655,000 | +655,000 | 0.00 | 0.64 | +0.64 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 630,048 | 651,888 | +21,840 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 628,887 | +628,887 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 537,102 | 594,173 | +57,071 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 716,964 | 579,659 | -137,305 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 111,734 | 561,183 | +449,449 | 0.42 | 1.87 | +1.44 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,028,568 | 541,538 | -487,030 | 0.15 | 0.06 | -0.09 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 529,365 | +529,365 | 0.00 | 0.33 | +0.33 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 500,000 | +500,000 | 0.00 | 0.10 | +0.10 | buy |
| MORGAN STANLEY | 452,434 | 424,434 | -28,000 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 386,000 | +386,000 | 0.00 | 0.40 | +0.40 | buy |
| Candriam S.C.A. | 0 | 350,000 | +350,000 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 37,517 | 344,449 | +306,932 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 326,496 | 317,868 | -8,628 | 0.00 | 0.00 | -0.00 | sell |
| Rosalind Advisors, Inc. | 300,000 | 287,985 | -12,015 | 3.07 | 3.19 | +0.12 | sell |
| CITIGROUP INC | 281,909 | 282,883 | +974 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 254,774 | +254,774 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 42,300 | 243,484 | +201,184 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 304,277 | 219,277 | -85,000 | 2.32 | 2.41 | +0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 165,759 | 191,699 | +25,940 | 0.00 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 182,644 | +182,644 | 0.00 | 0.22 | +0.22 | buy |
| Qube Research & Technologies Ltd | 0 | 178,738 | +178,738 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 346,863 | 150,462 | -196,401 | 0.05 | 0.02 | -0.03 | sell |
| TWO SIGMA ADVISERS, LP | 202,522 | 146,322 | -56,200 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 97,830 | 120,308 | +22,478 | 0.02 | 0.02 | -0.00 | buy |
| Bank of New York Mellon Corp | 100,693 | 112,053 | +11,360 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 26,792 | 90,560 | +63,768 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 88,763 | 87,093 | -1,670 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 783,698 | 87,084 | -696,614 | 0.01 | 0.00 | -0.01 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 82,000 | +82,000 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 79,365 | +79,365 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 80,451 | 78,138 | -2,313 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 0 | 70,000 | +70,000 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 110,922 | 68,205 | -42,717 | 0.01 | 0.00 | -0.00 | sell |
| Atom Investors LP | 69,844 | 65,005 | -4,839 | 0.15 | 0.10 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 87,099 | 59,831 | -27,268 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 55,444 | +55,444 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 50,970 | 50,907 | -63 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 45,361 | 47,320 | +1,959 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 40,000 | 46,000 | +6,000 | 0.38 | 0.44 | +0.06 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,100 | 45,000 | -6,100 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 41,951 | +41,951 | 0.00 | 0.05 | +0.05 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 40,863 | +40,863 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,914 | 38,705 | +28,791 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 1,080,000 | 35,000 | -1,045,000 | 0.21 | 0.01 | -0.20 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 51,500 | 33,500 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 29,063 | 32,723 | +3,660 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 32,025 | +32,025 | 0.00 | 0.25 | +0.25 | buy |
| HighVista Strategies LLC | 0 | 31,873 | +31,873 | 0.00 | 0.13 | +0.13 | buy |
| ALLIANCEBERNSTEIN L.P. | 30,010 | 30,010 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 27,104 | 28,517 | +1,413 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 32,591 | 23,955 | -8,636 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 0 | 23,674 | +23,674 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,198 | 22,142 | +944 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 42,531 | 21,955 | -20,576 | 0.00 | 0.00 | -0.00 | sell |
| LINCOLN NATIONAL CORP | 0 | 20,660 | +20,660 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 20,615 | +20,615 | 0.00 | 0.31 | +0.31 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,971 | 19,886 | -7,085 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 19,329 | +19,329 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 18,338 | 18,338 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 9,263 | 18,013 | +8,750 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,776 | 16,776 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 16,179 | +16,179 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 15,500 | +15,500 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,389 | 15,431 | +42 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 15,353 | +15,353 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,831 | 14,559 | +3,728 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,467 | +14,467 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,477 | 13,972 | +495 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 11,544 | 12,196 | +652 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,897 | 12,123 | -774 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 137,817 | 12,082 | -125,735 | 0.02 | 0.00 | -0.02 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 0 | 11,488 | +11,488 | 0.00 | 0.07 | +0.07 | buy |
| Mirae Asset Global Investments Co., Ltd. | 10,260 | 10,635 | +375 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,538 | +10,538 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,539 | 10,290 | -2,249 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 11,529 | 10,234 | -1,295 | 0.00 | 0.00 | -0.00 | sell |
| Entropy Technologies, LP | 0 | 10,172 | +10,172 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 41,365 | 10,004 | -31,361 | 0.05 | 0.01 | -0.04 | sell |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 3,981 | 8,024 | +4,043 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 7,784 | +7,784 | 0.00 | 0.08 | +0.08 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4,339 | 4,351 | +12 | 0.00 | 0.00 | -0.00 | buy |