| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 4,092,731 | 6,249,731 | +2,157,000 | 3.44 | 3.53 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 705,000 | 2,575,000 | +1,870,000 | 0.02 | 0.06 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,684,005 | 4,192,005 | +1,508,000 | 1.49 | 1.85 | +0.36 | buy |
| STEMPOINT CAPITAL LP | 423,174 | 1,161,060 | +737,886 | 1.40 | 3.68 | +2.28 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,440,345 | 4,125,345 | +685,000 | 3.89 | 5.09 | +1.20 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 111,734 | 561,183 | +449,449 | 0.42 | 1.87 | +1.44 | buy |
| DAFNA Capital Management LLC | 601,032 | 806,973 | +205,941 | 1.76 | 2.18 | +0.41 | buy |
| Frazier Life Sciences Management, L.P. | 3,622,294 | 3,687,867 | +65,573 | 2.37 | 1.85 | -0.53 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 110,922 | 68,205 | +42,717 | 0.01 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 40,000 | 46,000 | +6,000 | 0.38 | 0.44 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 3,981 | 8,024 | +4,043 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 69,844 | 65,005 | -4,839 | 0.15 | 0.10 | -0.05 | sell |
| Rosalind Advisors, Inc. | 300,000 | 287,985 | -12,015 | 3.03 | 3.19 | +0.16 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 51,500 | 33,500 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 304,277 | 219,277 | -85,000 | 2.32 | 2.41 | +0.09 | sell |
| Woodline Partners LP | 346,863 | 150,462 | -196,401 | 0.05 | 0.02 | -0.03 | sell |
| Saturn V Capital Management LP | 1,807,563 | 1,441,952 | -365,611 | 8.48 | 6.86 | -1.62 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,028,568 | 541,538 | -487,030 | 0.15 | 0.06 | -0.09 | sell |
| TCG Crossover Management, LLC | 3,395,495 | 1,163,356 | -2,232,139 | 4.61 | 1.09 | -3.52 | sell |