| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 612,173 | 1,698,984 | +1,086,811 | 1.16 | 4.10 | +2.94 | buy |
| Parkman Healthcare Partners LLC | 0 | 753,752 | +753,752 | 0.00 | 1.03 | +1.03 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 581,746 | +581,746 | 0.00 | 0.05 | +0.05 | buy |
| VR Adviser, LLC | 6,249,731 | 6,703,985 | +454,254 | 3.63 | 6.58 | +2.95 | buy |
| JPMORGAN CHASE & CO | 21,260 | 402,504 | +381,244 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,288,401 | 1,617,469 | +329,068 | 0.07 | 0.12 | +0.05 | buy |
| BlackRock, Inc. | 2,863,996 | 3,151,735 | +287,739 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 198,205 | +198,205 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 110,050 | 308,247 | +198,197 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 135,509 | +135,509 | 0.00 | 1.25 | +1.25 | buy |
| UBS Group AG | 374,631 | 507,703 | +133,072 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 822,352 | 915,241 | +92,889 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 805,445 | 868,011 | +62,566 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 836,050 | 898,190 | +62,140 | 0.27 | 0.47 | +0.19 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 549,688 | 608,213 | +58,525 | 0.28 | 0.50 | +0.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 55,975 | +55,975 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 50,097 | +50,097 | 0.00 | 0.02 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,893,847 | 4,941,798 | +47,951 | 2.74 | 3.15 | +0.41 | buy |
| VANGUARD GROUP INC | 2,255,243 | 2,298,598 | +43,355 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 74,827 | 111,106 | +36,279 | 0.03 | 0.06 | +0.03 | buy |
| Creative Planning | 113 | 27,807 | +27,694 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 25,842 | +25,842 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 15,640 | 39,804 | +24,164 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,178 | 52,168 | +22,990 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 21,550 | +21,550 | 0.00 | 0.24 | +0.24 | buy |
| NORTHERN TRUST CORP | 366,170 | 387,562 | +21,392 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,348 | 113,124 | +12,776 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 327,673 | 339,936 | +12,263 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 10,915 | +10,915 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 8,400 | +8,400 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 98,547 | 103,530 | +4,983 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 36 | 4,585 | +4,549 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 3,845 | +3,845 | 0.00 | 0.40 | +0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 122,863 | 126,268 | +3,405 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,839 | 16,823 | +2,984 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,386 | 24,325 | +2,939 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,165 | 22,862 | +2,697 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,152 | 21,688 | +2,536 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 16,945 | 19,094 | +2,149 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 51,156 | 52,918 | +1,762 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 103 | 1,287 | +1,184 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 82,005 | 82,896 | +891 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 166 | 979 | +813 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,204 | 17,888 | +684 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 570 | +570 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,144 | 8,540 | +396 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 347 | +347 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 337 | +337 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,065 | 1,343 | +278 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,023 | 1,247 | +224 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4,339 | 4,557 | +218 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 196 | +196 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 519 | 711 | +192 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 81 | 268 | +187 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 105 | +90 | 0.00 | 0.00 | +0.00 | buy |
| EVOKE WEALTH, LLC | 32,363 | 32,446 | +83 | 0.01 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 21 | 102 | +81 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,623 | 1,640 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 67,000 | 67,002 | +2 | 0.46 | 0.67 | +0.21 | buy |
| Ameritas Investment Partners, Inc. | 3,731 | 3,731 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,511 | 2,511 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 11,488 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Sterling Capital Management LLC | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 33,305 | 33,305 | 0 | 0.10 | 0.15 | +0.04 | hold |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 154 | 154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,913,012 | 4,913,012 | 0 | 1.54 | 2.29 | +0.75 | hold |
| Rosalind Advisors, Inc. | 303,864 | 303,864 | 0 | 1.39 | 1.71 | +0.32 | hold |
| IFP Advisors, Inc | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nan Fung Group Holdings Ltd | 154,522 | 154,522 | 0 | 1.12 | 1.45 | +0.33 | hold |
| Octagon Capital Advisors LP | 1,370,000 | 1,370,000 | 0 | 1.97 | 2.16 | +0.19 | hold |
| SBI Securities Co., Ltd. | 94 | 94 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 4,887,867 | 4,887,867 | 0 | 1.72 | 2.58 | +0.86 | hold |
| 1620 INVESTMENT ADVISORS, INC. | 1,590 | 1,590 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 157 | 157 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 7,695 | 7,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Martin Worley Group | 10,168 | 10,168 | 0 | 0.05 | 0.07 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,964 | 9,964 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 71,896 | 71,896 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wilmington Savings Fund Society, FSB | 415 | 415 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 375,000 | 375,000 | 0 | 0.04 | 0.07 | +0.04 | hold |
| Smartleaf Asset Management LLC | 306 | 279 | -27 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 35,843 | 35,743 | -100 | 0.06 | 0.08 | +0.02 | sell |
| R Squared Ltd | 110 | 0 | -110 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 664 | 384 | -280 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,193 | 13,808 | -385 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,329 | 9,912 | -417 | 0.01 | 0.01 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,164 | 0 | -1,164 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,906 | 10,666 | -1,240 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,390 | 10,239 | -2,151 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 172,693 | 169,692 | -3,001 | 0.04 | 0.05 | +0.01 | sell |