| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 612,173 | 1,698,984 | +1,086,811 | 1.16 | 4.10 | +2.94 | buy |
| VR Adviser, LLC | 6,249,731 | 6,703,985 | +454,254 | 3.63 | 6.58 | +2.95 | buy |
| Woodline Partners LP | 1,288,401 | 1,617,469 | +329,068 | 0.07 | 0.12 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 805,445 | 868,011 | +62,566 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 836,050 | 898,190 | +62,140 | 0.27 | 0.47 | +0.19 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 549,688 | 608,213 | +58,525 | 0.28 | 0.50 | +0.21 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,893,847 | 4,941,798 | +47,951 | 2.74 | 3.15 | +0.41 | buy |
| Hennion & Walsh Asset Management, Inc. | 74,827 | 111,106 | +36,279 | 0.03 | 0.06 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 172,693 | 169,692 | +3,001 | 0.12 | 0.16 | 0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,023 | 1,247 | +224 | 0.00 | 0.00 | +0.00 | buy |
| EVOKE WEALTH, LLC | 32,363 | 32,446 | +83 | 0.01 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 67,000 | 67,002 | +2 | 0.46 | 0.67 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 35,843 | 35,743 | -100 | 0.06 | 0.08 | +0.02 | sell |
| China Universal Asset Management Co., Ltd. | 10,329 | 9,912 | -417 | 0.01 | 0.01 | +0.00 | sell |
| Persistent Asset Partners Ltd | 41,952 | 34,098 | -7,854 | 0.32 | 0.35 | +0.03 | sell |
| PDT Partners, LLC | 35,201 | 23,654 | -11,547 | 0.03 | 0.02 | -0.01 | sell |
| Vestal Point Capital, LP | 4,770,000 | 4,751,292 | -18,708 | 2.40 | 3.92 | +1.52 | sell |
| Allostery Investments LP | 479,100 | 458,302 | -20,798 | 7.97 | 7.63 | -0.34 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 276,000 | -24,000 | 0.00 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 54,466 | 26,269 | -28,197 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 811,678 | 752,359 | -59,319 | 1.75 | 2.46 | +0.71 | sell |
| Capital World Investors | 3,374,064 | 3,177,587 | -196,477 | 0.00 | 0.01 | +0.00 | sell |
| Saturn V Capital Management LP | 556,489 | 255,060 | -301,429 | 1.85 | 1.49 | -0.36 | sell |
| STEMPOINT CAPITAL LP | 992,803 | 386,837 | -605,966 | 2.11 | 1.43 | -0.68 | sell |
| GREAT POINT PARTNERS LLC | 1,787,003 | 1,014,367 | -772,636 | 7.13 | 6.20 | -0.93 | sell |