| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,728,985 | 6,474,485 | -254,500 | 5.37 | 4.86 | -0.50 | sell |
| Frazier Life Sciences Management, L.P. | 5,039,867 | 4,961,108 | -78,759 | 2.19 | 2.57 | +0.38 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,768,712 | 4,768,712 | 0 | 1.92 | 2.60 | +0.68 | hold |
| TANG CAPITAL MANAGEMENT LLC | 4,573,530 | 4,573,530 | 0 | 3.65 | 4.68 | +1.03 | hold |
| BlackRock, Inc. | 3,754,148 | 3,795,897 | +41,749 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,427,118 | 2,876,407 | +449,289 | 5.67 | 6.82 | +1.15 | buy |
| Capital World Investors | 2,808,583 | 2,808,583 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Point72 Asset Management, L.P. | 2,283,766 | 2,136,940 | -146,826 | 0.06 | 0.07 | +0.02 | sell |
| STATE STREET CORP | 1,911,691 | 1,955,844 | +44,153 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,896,666 | 1,912,146 | -984,520 | 0.03 | 0.03 | -0.00 | sell |
| Vestal Point Capital, LP | 1,890,000 | 1,850,000 | -40,000 | 1.12 | 1.04 | -0.08 | sell |
| Parkman Healthcare Partners LLC | 1,768,508 | 1,835,506 | +66,998 | 2.72 | 3.83 | +1.11 | buy |
| Kynam Capital Management, LP | 1,810,954 | 1,820,954 | +10,000 | 1.90 | 2.33 | +0.42 | buy |
| Woodline Partners LP | 1,921,092 | 1,509,920 | -411,172 | 0.12 | 0.11 | -0.01 | sell |
| Octagon Capital Advisors LP | 1,273,333 | 1,450,000 | +176,667 | 2.57 | 3.23 | +0.66 | buy |
| EMERALD ADVISERS, LLC | 1,340,495 | 1,264,023 | -76,472 | 0.67 | 0.81 | +0.14 | sell |
| ARMISTICE CAPITAL, LLC | 800,000 | 1,236,000 | +436,000 | 0.32 | 0.82 | +0.51 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 944,077 | 996,235 | +52,158 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 633,019 | 882,906 | +249,887 | 0.07 | 0.13 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 835,304 | 824,293 | -11,011 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 855,461 | 805,762 | -49,699 | 0.67 | 0.79 | +0.11 | sell |
| GREAT POINT PARTNERS LLC | 685,632 | 675,000 | -10,632 | 3.59 | 3.33 | -0.26 | sell |
| Bank of New York Mellon Corp | 695,175 | 584,347 | -110,828 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 564,039 | +564,039 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 389,813 | 555,628 | +165,815 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 700,573 | 537,061 | -163,512 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 371,993 | 515,650 | +143,657 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,171,755 | 506,743 | -665,012 | 0.01 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 700,228 | 439,099 | -261,129 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 0 | 426,551 | +426,551 | 0.00 | 1.79 | +1.79 | buy |
| Hennion & Walsh Asset Management, Inc. | 341,819 | 375,995 | +34,176 | 0.19 | 0.25 | +0.06 | buy |
| NORTHERN TRUST CORP | 351,973 | 363,694 | +11,721 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,369 | 323,451 | -918 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 305,880 | 315,537 | +9,657 | 0.02 | 0.05 | +0.03 | buy |
| HRT FINANCIAL LP | 287,052 | 286,916 | -136 | 0.01 | 0.01 | -0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 286,046 | +286,046 | 0.00 | 0.07 | +0.07 | buy |
| DAFNA Capital Management LLC | 356,802 | 267,402 | -89,400 | 1.34 | 1.22 | -0.11 | sell |
| Atom Investors LP | 276,113 | 245,993 | -30,120 | 0.35 | 0.35 | +0.00 | sell |
| CITIGROUP INC | 10,771 | 244,261 | +233,490 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 34,929 | 229,984 | +195,055 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 236,690 | 226,991 | -9,699 | 0.15 | 0.30 | +0.16 | sell |
| Blue Owl Capital Holdings LP | 360,000 | 215,000 | -145,000 | 1.79 | 1.16 | -0.63 | sell |
| FMR LLC | 111,807 | 187,848 | +76,041 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 180,314 | +180,314 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 20,061 | 177,274 | +157,213 | 0.00 | 0.04 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 162,908 | +162,908 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 154,522 | 154,522 | 0 | 0.20 | 0.34 | +0.14 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 153,459 | +153,459 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 143,966 | +143,966 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 129,517 | 140,651 | +11,134 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 139,458 | +139,458 | 0.00 | 0.02 | +0.02 | buy |
| Brevan Howard Capital Management LP | 59,147 | 125,049 | +65,902 | 0.02 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 122,379 | 107,262 | -15,117 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 107,129 | 106,864 | -265 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 37,761 | 97,726 | +59,965 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 382,400 | 94,400 | -288,000 | 0.13 | 0.04 | -0.08 | sell |
| Walleye Capital LLC | 0 | 79,666 | +79,666 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 26,508 | 79,118 | +52,610 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 77,864 | 75,282 | -2,582 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 30,939 | 69,945 | +39,006 | 0.01 | 0.04 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 64,249 | +64,249 | 0.00 | 0.07 | +0.07 | buy |
| Creative Planning | 44,082 | 59,986 | +15,904 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 65,593 | 57,296 | -8,297 | 0.00 | 0.00 | +0.00 | sell |
| Birchview Capital, LP | 57,000 | 57,000 | 0 | 0.54 | 0.65 | +0.11 | hold |
| Russell Investments Group, Ltd. | 56,249 | 56,192 | -57 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 54,900 | 54,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CenterBook Partners LP | 0 | 53,264 | +53,264 | 0.00 | 0.06 | +0.06 | buy |
| PANAGORA ASSET MANAGEMENT INC | 109,391 | 50,792 | -58,599 | 0.01 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 40,414 | 49,927 | +9,513 | 0.18 | 0.28 | +0.10 | buy |
| RHUMBLINE ADVISERS | 47,391 | 47,469 | +78 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,895 | 46,760 | -25,135 | 0.00 | 0.00 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 0 | 43,775 | +43,775 | 0.00 | 0.22 | +0.22 | buy |
| Man Group plc | 17,446 | 42,576 | +25,130 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 41,504 | 41,149 | -355 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 35,091 | 38,857 | +3,766 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,666 | 37,572 | +12,906 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 35,123 | +35,123 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 35,119 | 35,119 | 0 | 0.07 | 0.10 | +0.03 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 27,722 | 34,743 | +7,021 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 33,776 | +33,776 | 0.00 | 0.01 | +0.01 | buy |
| Quarry LP | 0 | 33,750 | +33,750 | 0.00 | 0.14 | +0.14 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 33,580 | -6,440 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 29,156 | 32,453 | +3,297 | 0.00 | 0.00 | +0.00 | buy |
| EVOKE WEALTH, LLC | 31,841 | 31,542 | -299 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,118 | 29,367 | +6,249 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 26,850 | +26,850 | 0.00 | 0.07 | +0.07 | buy |
| PROFUND ADVISORS LLC | 24,392 | 25,660 | +1,268 | 0.01 | 0.02 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 25,500 | +25,500 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,868 | 24,296 | +6,428 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 56,014 | 23,927 | -32,087 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 19,454 | 22,026 | +2,572 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,624 | 22,005 | +381 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 48,030 | 21,828 | -26,202 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Boxer Capital Management, LLC | 20,400 | 20,400 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Marex Group plc | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 23,818 | 19,787 | -4,031 | 0.00 | 0.00 | +0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | 16,711 | 0 | 0.11 | 0.14 | +0.03 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,923 | 16,292 | +369 | 0.00 | 0.00 | +0.00 | buy |