| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1,464,606 | 3,227,620 | +1,763,014 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 655,000 | 2,300,000 | +1,645,000 | 0.64 | 2.02 | +1.38 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,338,568 | +1,338,568 | 0.00 | 3.02 | +3.02 | buy |
| VANGUARD GROUP INC | 1,685,113 | 1,990,588 | +305,475 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 254,774 | 467,998 | +213,224 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 594,173 | 756,430 | +162,257 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 651,888 | 806,271 | +154,383 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 59,831 | 212,888 | +153,057 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 35,000 | 175,000 | +140,000 | 0.01 | 0.04 | +0.03 | buy |
| NORGES BANK | 0 | 131,300 | +131,300 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 760,722 | 881,937 | +121,215 | 1.45 | 1.61 | +0.16 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,125,345 | 4,218,829 | +93,484 | 5.09 | 5.06 | -0.03 | buy |
| Russell Investments Group, Ltd. | 0 | 78,682 | +78,682 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 16,179 | 68,526 | +52,347 | 0.01 | 0.02 | +0.01 | buy |
| Rosalind Advisors, Inc. | 287,985 | 337,985 | +50,000 | 3.19 | 3.15 | -0.05 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 82,000 | 122,960 | +40,960 | 0.03 | 0.04 | +0.01 | buy |
| Corton Capital Inc. | 0 | 39,593 | +39,593 | 0.00 | 0.24 | +0.24 | buy |
| BANK OF AMERICA CORP /DE/ | 23,955 | 62,507 | +38,552 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 78,138 | 110,594 | +32,456 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 112,053 | 135,600 | +23,547 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 21,380 | +21,380 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,000 | 60,755 | +15,755 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 10,004 | 25,522 | +15,518 | 0.01 | 0.03 | +0.02 | buy |
| EVOKE WEALTH, LLC | 0 | 15,373 | +15,373 | 0.00 | 0.27 | +0.27 | buy |
| Verition Fund Management LLC | 0 | 15,113 | +15,113 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 317,868 | 332,695 | +14,827 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 87,093 | 100,061 | +12,968 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 30,010 | 42,450 | +12,440 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 47,320 | 53,228 | +5,908 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,776 | 22,289 | +5,513 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 79,365 | 84,023 | +4,658 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,596 | 6,380 | +3,784 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,691 | +3,691 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 12,196 | 15,858 | +3,662 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,123 | 15,437 | +3,314 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,142 | 25,352 | +3,210 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 282,883 | 286,064 | +3,181 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,290 | 13,415 | +3,125 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 50,907 | 54,026 | +3,119 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 2,100 | +2,100 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 12,020 | +2,020 | 0.03 | 0.03 | -0.00 | buy |
| Nicholas Investment Partners, LP | 182,644 | 184,358 | +1,714 | 0.22 | 0.23 | +0.00 | buy |
| 1620 INVESTMENT ADVISORS, INC. | 0 | 1,590 | +1,590 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 14,559 | 15,932 | +1,373 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,468 | 3,731 | +1,263 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,972 | 14,280 | +308 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 198 | 350 | +152 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 519 | 652 | +133 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 30 | +30 | 0.00 | 0.00 | 0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4,351 | 4,380 | +29 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,705 | 38,733 | +28 | 0.00 | 0.00 | -0.00 | buy |
| Creekmur Asset Management LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 11,488 | 0 | 0.07 | 0.07 | +0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 500,000 | 500,000 | 0 | 0.10 | 0.14 | +0.04 | hold |
| HighVista Strategies LLC | 31,873 | 31,873 | 0 | 0.13 | 0.14 | +0.00 | hold |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 529,365 | 529,365 | 0 | 0.33 | 0.33 | -0.00 | hold |
| DAFNA Capital Management LLC | 806,973 | 806,973 | 0 | 2.18 | 2.27 | +0.09 | hold |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legato Capital Management LLC | 23,674 | 23,674 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Daiwa Securities Group Inc. | 154 | 154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,192,005 | 4,192,005 | 0 | 2.10 | 2.02 | -0.08 | hold |
| VR Adviser, LLC | 6,249,731 | 6,249,731 | 0 | 3.53 | 4.69 | +1.16 | hold |
| Birchview Capital, LP | 46,000 | 46,000 | 0 | 0.44 | 0.50 | +0.06 | hold |
| Nan Fung Group Holdings Ltd | 219,277 | 219,277 | 0 | 2.41 | 2.76 | +0.35 | hold |
| Woodline Partners LP | 150,462 | 150,462 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 3,687,867 | 3,687,867 | 0 | 1.85 | 2.03 | +0.19 | hold |
| Red Tortoise LLC | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortitude Family Office, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 18,338 | 18,338 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMALGAMATED BANK | 1,065 | 1,065 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,500 | 1,436 | -64 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 81 | 0 | -81 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 561,183 | 560,883 | -300 | 1.87 | 1.63 | -0.24 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,148 | 2,759 | -389 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 414 | 0 | -414 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 1,800 | 0 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,820 | 0 | -1,820 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,426 | 1,215 | -2,211 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,024 | 4,958 | -3,066 | 0.01 | 0.01 | -0.00 | sell |
| STRS OHIO | 3,600 | 0 | -3,600 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 32,723 | 28,939 | -3,784 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 7,784 | 3,530 | -4,254 | 0.08 | 0.02 | -0.06 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,353 | 10,841 | -4,512 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 541,538 | 535,717 | -5,821 | 0.06 | 0.06 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,886 | 13,486 | -6,400 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 70,000 | 62,704 | -7,296 | 0.02 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 21,955 | 12,965 | -8,990 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 10,635 | 1,260 | -9,375 | 0.00 | 0.00 | -0.00 | sell |
| Entropy Technologies, LP | 10,172 | 0 | -10,172 | 0.01 | 0.00 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,234 | 0 | -10,234 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,538 | 0 | -10,538 | 0.00 | 0.00 | -0.00 | sell |