| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1,464,606 | 3,227,620 | +1,763,014 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 655,000 | 2,300,000 | +1,645,000 | 0.64 | 2.02 | +1.38 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 254,774 | 467,998 | +213,224 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 760,722 | 881,937 | +121,215 | 1.45 | 1.61 | +0.16 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,125,345 | 4,218,829 | +93,484 | 5.09 | 5.06 | -0.03 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 16,179 | 68,526 | +52,347 | 0.01 | 0.02 | +0.01 | buy |
| Rosalind Advisors, Inc. | 287,985 | 337,985 | +50,000 | 3.19 | 3.06 | -0.13 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 82,000 | 122,960 | +40,960 | 0.07 | 0.09 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 12,020 | +2,020 | 0.03 | 0.03 | -0.00 | buy |
| Nicholas Investment Partners, LP | 182,644 | 184,358 | +1,714 | 0.22 | 0.23 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 561,183 | 560,883 | -300 | 1.87 | 1.63 | -0.24 | sell |
| China Universal Asset Management Co., Ltd. | 8,024 | 4,958 | -3,066 | 0.01 | 0.01 | -0.00 | sell |
| EntryPoint Capital, LLC | 7,784 | 3,530 | -4,254 | 0.08 | 0.06 | -0.02 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,353 | 10,841 | -4,512 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 541,538 | 535,717 | -5,821 | 0.06 | 0.06 | -0.00 | sell |
| Zimmer Partners, LP | 70,000 | 62,704 | -7,296 | 0.02 | 0.01 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 671,176 | 643,897 | -27,279 | 0.32 | 0.32 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 33,500 | 4,500 | -29,000 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 65,005 | 19,901 | -45,104 | 0.10 | 0.02 | -0.07 | sell |
| First Turn Management, LLC | 1,179,420 | 1,059,540 | -119,880 | 2.09 | 2.03 | -0.06 | sell |
| Saturn V Capital Management LP | 1,441,952 | 1,128,478 | -313,474 | 6.86 | 5.02 | -1.83 | sell |
| STEMPOINT CAPITAL LP | 1,161,060 | 736,765 | -424,295 | 3.68 | 2.55 | -1.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,575,000 | 2,050,000 | -525,000 | 0.06 | 0.04 | -0.01 | sell |