| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AMERIPRISE FINANCIAL INC | 40,072 | 945,125 | +905,053 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,617,469 | 1,920,664 | +303,195 | 0.12 | 0.11 | -0.01 | buy |
| STATE STREET CORP | 1,093,643 | 1,349,539 | +255,896 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,168 | 294,198 | +242,030 | 0.00 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 71,896 | 292,593 | +220,697 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 0 | 214,138 | +214,138 | 0.00 | 0.45 | +0.45 | buy |
| Ikarian Capital, LLC | 0 | 198,528 | +198,528 | 0.00 | 0.74 | +0.74 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 608,213 | 768,972 | +160,759 | 0.50 | 0.53 | +0.03 | buy |
| Octagon Capital Advisors LP | 1,115,000 | 1,273,333 | +158,333 | 0.81 | 3.16 | +2.35 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 154,522 | +154,522 | 0.00 | 0.21 | +0.21 | buy |
| CITIGROUP INC | 148,227 | 299,194 | +150,967 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 148,927 | +148,927 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 198,205 | 340,629 | +142,424 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 898,190 | 1,038,049 | +139,859 | 0.47 | 0.43 | -0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,698,984 | 1,832,171 | +133,187 | 4.10 | 4.24 | +0.14 | buy |
| F/m Investments LLC | 50,097 | 182,262 | +132,165 | 0.02 | 0.07 | +0.05 | buy |
| VANGUARD GROUP INC | 2,298,598 | 2,412,399 | +113,801 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 55,227 | 168,923 | +113,696 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 101,035 | +101,035 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 97,248 | +97,248 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 93,400 | +93,400 | 0.00 | 0.53 | +0.53 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 92,259 | +92,259 | 0.00 | 0.02 | +0.02 | buy |
| Stonepine Capital Management, LLC | 21,550 | 100,000 | +78,450 | 0.24 | 1.11 | +0.87 | buy |
| ROYAL BANK OF CANADA | 0 | 64,294 | +64,294 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 308,247 | 366,966 | +58,719 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 11,228 | 68,539 | +57,311 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 54,910 | +54,910 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 82,896 | 133,566 | +50,670 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 111,106 | 155,961 | +44,855 | 0.06 | 0.07 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,913,012 | 4,955,000 | +41,988 | 2.29 | 2.11 | -0.18 | buy |
| MARSHALL WACE, LLP | 80,965 | 119,622 | +38,657 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 33,900 | +33,900 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 30,739 | +30,739 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 26,386 | +26,386 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 915,241 | 941,212 | +25,971 | 0.00 | 0.00 | -0.00 | buy |
| VR Adviser, LLC | 6,703,985 | 6,728,985 | +25,000 | 6.58 | 5.70 | -0.88 | buy |
| OSAIC HOLDINGS, INC. | 0 | 21,915 | +21,915 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 26,269 | 46,901 | +20,632 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 19,973 | +19,973 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 16,312 | +16,312 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 223,789 | 239,629 | +15,840 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 13,333 | +13,333 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 12,781 | +12,781 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,043 | 73,343 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 39,804 | 50,761 | +10,957 | 0.00 | 0.00 | +0.00 | buy |
| Whalen Wealth Management Inc. | 0 | 10,938 | +10,938 | 0.00 | 0.08 | +0.08 | buy |
| PROFUND ADVISORS LLC | 0 | 10,020 | +10,020 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 8,400 | 16,796 | +8,396 | 0.02 | 0.04 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,184 | +7,184 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 879 | 8,059 | +7,180 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,268 | 132,900 | +6,632 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 27,807 | 33,380 | +5,573 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 16,711 | +5,223 | 0.07 | 0.09 | +0.02 | buy |
| GROUP ONE TRADING LLC | 0 | 4,963 | +4,963 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 103,530 | 107,635 | +4,105 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,543 | +3,543 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,862 | 25,324 | +2,462 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,695 | 9,756 | +2,061 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,918 | 54,376 | +1,458 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 1,324 | +1,324 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,749 | 4,041 | +1,292 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 268 | 1,392 | +1,124 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,823 | 17,864 | +1,041 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,808 | 14,626 | +818 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,239 | 10,714 | +475 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 25,842 | 26,257 | +415 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,124 | 113,496 | +372 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 102 | 449 | +347 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,640 | 1,921 | +281 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 1,287 | 1,423 | +136 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 131 | +131 | 0.00 | 0.00 | +0.00 | buy |
| TOTH FINANCIAL ADVISORY CORP | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,912 | 9,985 | +73 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 384 | 441 | +57 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 41 | 91 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 979 | 1,024 | +45 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 53,028 | 53,069 | +41 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 105 | 140 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 144 | 166 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Parkworth Wealth Management, Inc. | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 31 | 45 | +14 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 25,720 | 25,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,731 | 3,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,511 | 2,511 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 4,941,798 | 4,941,798 | 0 | 3.15 | 2.82 | -0.33 | hold |
| CIBC Private Wealth Group LLC | 160 | 160 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital World Investors | 3,177,587 | 3,177,587 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 154 | 154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 94 | 94 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 4,887,867 | 4,887,867 | 0 | 2.58 | 2.21 | -0.37 | hold |
| 1620 INVESTMENT ADVISORS, INC. | 1,590 | 1,590 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Farther Finance Advisors, LLC | 196 | 196 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Martin Worley Group | 10,168 | 10,168 | 0 | 0.07 | 0.06 | -0.01 | hold |