| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,703,985 | 6,728,985 | +25,000 | 6.58 | 5.70 | -0.88 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,913,012 | 4,955,000 | +41,988 | 2.29 | 2.11 | -0.18 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,941,798 | 4,941,798 | 0 | 3.15 | 2.82 | -0.33 | hold |
| Frazier Life Sciences Management, L.P. | 4,887,867 | 4,887,867 | 0 | 2.58 | 2.21 | -0.37 | hold |
| Vestal Point Capital, LP | 4,751,292 | 4,675,000 | -76,292 | 3.92 | 2.78 | -1.13 | sell |
| Capital World Investors | 3,177,587 | 3,177,587 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BlackRock, Inc. | 3,151,735 | 3,129,494 | -22,241 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,298,598 | 2,412,399 | +113,801 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,617,469 | 1,920,664 | +303,195 | 0.12 | 0.11 | -0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,698,984 | 1,832,171 | +133,187 | 4.10 | 4.24 | +0.14 | buy |
| STATE STREET CORP | 1,093,643 | 1,349,539 | +255,896 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,115,000 | 1,273,333 | +158,333 | 0.81 | 3.16 | +2.35 | buy |
| EMERALD ADVISERS, LLC | 898,190 | 1,038,049 | +139,859 | 0.47 | 0.43 | -0.04 | buy |
| AMERIPRISE FINANCIAL INC | 40,072 | 945,125 | +905,053 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 915,241 | 941,212 | +25,971 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 608,213 | 768,972 | +160,759 | 0.50 | 0.53 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 753,752 | 679,063 | -74,689 | 1.03 | 0.89 | -0.14 | sell |
| DAFNA Capital Management LLC | 752,359 | 581,757 | -170,602 | 2.46 | 1.82 | -0.65 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 868,011 | 554,958 | -313,053 | 0.01 | 0.01 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 386,837 | 386,790 | -47 | 1.43 | 1.41 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 308,247 | 366,966 | +58,719 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 387,562 | 352,152 | -35,410 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 198,205 | 340,629 | +142,424 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,014,367 | 323,170 | -691,197 | 6.36 | 2.38 | -3.99 | sell |
| CITIGROUP INC | 148,227 | 299,194 | +150,967 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,168 | 294,198 | +242,030 | 0.00 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 71,896 | 292,593 | +220,697 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 507,703 | 272,861 | -234,842 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 223,789 | 239,629 | +15,840 | 0.00 | 0.00 | -0.00 | buy |
| First Turn Management, LLC | 0 | 214,138 | +214,138 | 0.00 | 0.45 | +0.45 | buy |
| Ikarian Capital, LLC | 0 | 198,528 | +198,528 | 0.00 | 0.74 | +0.74 | buy |
| F/m Investments LLC | 50,097 | 182,262 | +132,165 | 0.02 | 0.07 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 645,993 | 173,209 | -472,784 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 55,227 | 168,923 | +113,696 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 303,864 | 157,725 | -146,139 | 1.71 | 0.86 | -0.85 | sell |
| Hennion & Walsh Asset Management, Inc. | 111,106 | 155,961 | +44,855 | 0.06 | 0.07 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 154,522 | +154,522 | 0.00 | 0.21 | +0.21 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 148,927 | +148,927 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 581,746 | 145,282 | -436,464 | 0.05 | 0.01 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 339,936 | 134,398 | -205,538 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 82,896 | 133,566 | +50,670 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,268 | 132,900 | +6,632 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 80,965 | 119,622 | +38,657 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,124 | 113,496 | +372 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 103,530 | 107,635 | +4,105 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 101,035 | +101,035 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 21,550 | 100,000 | +78,450 | 0.24 | 1.11 | +0.87 | buy |
| Qube Research & Technologies Ltd | 0 | 97,248 | +97,248 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 93,400 | +93,400 | 0.00 | 0.53 | +0.53 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 92,259 | +92,259 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 169,692 | 79,460 | -90,232 | 0.05 | 0.02 | -0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,043 | 73,343 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 11,228 | 68,539 | +57,311 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 67,002 | 67,000 | -2 | 0.67 | 0.75 | +0.08 | sell |
| ROYAL BANK OF CANADA | 0 | 64,294 | +64,294 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 255,060 | 62,793 | -192,267 | 1.49 | 0.29 | -1.20 | sell |
| JANE STREET GROUP, LLC | 0 | 54,910 | +54,910 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,918 | 54,376 | +1,458 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 53,028 | 53,069 | +41 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 39,804 | 50,761 | +10,957 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 55,975 | 47,413 | -8,562 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 26,269 | 46,901 | +20,632 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allostery Investments LP | 458,302 | 40,000 | -418,302 | 7.63 | 5.76 | -1.87 | sell |
| OMERS ADMINISTRATION Corp | 0 | 33,900 | +33,900 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 27,807 | 33,380 | +5,573 | 0.00 | 0.00 | +0.00 | buy |
| EVOKE WEALTH, LLC | 32,446 | 32,181 | -265 | 0.01 | 0.01 | -0.00 | sell |
| Virtu Financial LLC | 0 | 30,739 | +30,739 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 43,143 | 28,884 | -14,259 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 32,126 | 28,474 | -3,652 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 26,386 | +26,386 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 25,842 | 26,257 | +415 | 0.01 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 25,720 | 25,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 22,862 | 25,324 | +2,462 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 402,504 | 23,218 | -379,286 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,325 | 22,964 | -1,361 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 21,915 | +21,915 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadrature Capital Ltd | 0 | 19,973 | +19,973 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,823 | 17,864 | +1,041 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,888 | 17,671 | -217 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 8,400 | 16,796 | +8,396 | 0.02 | 0.04 | +0.02 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 16,711 | +5,223 | 0.07 | 0.09 | +0.02 | buy |
| Atom Investors LP | 0 | 16,312 | +16,312 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,808 | 14,626 | +818 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 13,333 | +13,333 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 12,781 | +12,781 | 0.00 | 0.00 | +0.00 | buy |
| Whalen Wealth Management Inc. | 0 | 10,938 | +10,938 | 0.00 | 0.08 | +0.08 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,239 | 10,714 | +475 | 0.00 | 0.00 | -0.00 | buy |
| Martin Worley Group | 10,168 | 10,168 | 0 | 0.07 | 0.06 | -0.01 | hold |
| PROFUND ADVISORS LLC | 0 | 10,020 | +10,020 | 0.00 | 0.00 | +0.00 | buy |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 35,743 | 10,000 | -25,743 | 0.08 | 0.02 | -0.06 | sell |
| China Universal Asset Management Co., Ltd. | 9,912 | 9,985 | +73 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,964 | 9,964 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 7,695 | 9,756 | +2,061 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 879 | 8,059 | +7,180 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,184 | +7,184 | 0.00 | 0.03 | +0.03 | buy |