| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,651,393 | 3,440,345 | +788,952 | 3.51 | 4.67 | +1.16 | buy |
| Saturn V Capital Management LP | 1,412,336 | 1,810,246 | +397,910 | 7.05 | 7.30 | +0.25 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,034,506 | 2,420,851 | +386,345 | 0.98 | 1.26 | +0.28 | buy |
| Affinity Asset Advisors, LLC | 178,292 | 278,292 | +100,000 | 0.63 | 0.88 | +0.24 | buy |
| Atom Investors LP | 33,559 | 65,286 | +31,727 | 0.11 | 0.14 | +0.03 | buy |
| Nan Fung Group Holdings Ltd | 204,720 | 234,573 | +29,853 | 1.18 | 1.83 | +0.65 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 107,975 | 104,668 | +3,307 | 0.00 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 26,290 | 23,250 | +3,040 | 0.01 | 0.01 | 0.00 | sell |
| Ikarian Capital, LLC | 140,000 | 142,692 | +2,692 | 0.44 | 0.51 | +0.07 | buy |
| PDT Partners, LLC | 37,306 | 37,754 | +448 | 0.05 | 0.05 | -0.00 | buy |
| ALPS ADVISORS INC | 25,116 | 25,338 | +222 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,035,935 | 1,034,623 | -1,312 | 0.12 | 0.13 | +0.01 | sell |
| DAFNA Capital Management LLC | 611,032 | 605,532 | -5,500 | 1.50 | 1.81 | +0.31 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,104,339 | 1,056,691 | -47,648 | 0.02 | 0.02 | +0.00 | sell |
| MPM BioImpact LLC | 761,538 | 577,958 | -183,580 | 1.38 | 1.49 | +0.11 | sell |
| Opaleye Management Inc. | 720,000 | 500,000 | -220,000 | 1.55 | 1.57 | +0.02 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 720,508 | 228,934 | -491,574 | 2.19 | 0.82 | -1.37 | sell |