| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 2,300,000 | 4,000,000 | +1,700,000 | 2.02 | 3.65 | +1.63 | buy |
| Woodline Partners LP | 150,462 | 608,253 | +457,791 | 0.02 | 0.06 | +0.04 | buy |
| EMERALD ADVISERS, LLC | 643,897 | 835,988 | +192,091 | 0.32 | 0.37 | +0.06 | buy |
| Capital World Investors | 3,227,620 | 3,374,064 | +146,444 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 529,365 | 650,980 | +121,615 | 0.33 | 0.39 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,218,829 | 4,321,547 | +102,718 | 5.06 | 3.57 | -1.49 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 467,998 | 431,232 | +36,766 | 0.01 | 0.01 | -0.00 | sell |
| Birchview Capital, LP | 46,000 | 82,000 | +36,000 | 0.50 | 0.82 | +0.32 | buy |
| Zimmer Partners, LP | 62,704 | 95,704 | +33,000 | 0.01 | 0.02 | +0.01 | buy |
| EntryPoint Capital, LLC | 3,530 | 24,322 | +20,792 | 0.06 | 0.16 | +0.10 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,192,005 | 4,212,005 | +20,000 | 1.81 | 1.56 | -0.25 | buy |
| EVOKE WEALTH, LLC | 15,373 | 32,363 | +16,990 | 0.27 | 0.01 | -0.26 | buy |
| MPM BioImpact LLC | 881,937 | 896,915 | +14,978 | 1.61 | 1.56 | -0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 560,883 | 574,558 | +13,675 | 1.63 | 1.50 | -0.13 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 122,960 | 135,552 | +12,592 | 0.09 | 0.12 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,958 | 8,286 | +3,328 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 10,841 | 13,255 | +2,414 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 12,020 | 14,143 | +2,123 | 0.03 | 0.03 | -0.00 | buy |
| HighVista Strategies LLC | 31,873 | 33,305 | +1,432 | 0.14 | 0.13 | -0.00 | buy |
| nVerses Capital, LLC | 2,100 | 200 | -1,900 | 0.01 | 0.00 | -0.01 | sell |
| Rosalind Advisors, Inc. | 337,985 | 303,864 | -34,121 | 3.06 | 2.25 | -0.81 | sell |
| GREAT POINT PARTNERS LLC | 1,338,568 | 1,299,503 | -39,065 | 3.02 | 4.43 | +1.41 | sell |
| Nan Fung Group Holdings Ltd | 219,277 | 154,522 | -64,755 | 2.76 | 1.54 | -1.21 | sell |
| DAFNA Capital Management LLC | 806,973 | 723,678 | -83,295 | 2.27 | 1.98 | -0.29 | sell |
| Saturn V Capital Management LP | 1,128,478 | 556,489 | -571,989 | 5.02 | 2.30 | -2.72 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,050,000 | 1,419,792 | -630,208 | 0.04 | 0.03 | -0.02 | sell |
| First Turn Management, LLC | 1,059,540 | 355,000 | -704,540 | 2.03 | 0.65 | -1.38 | sell |