| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,249,731 | 6,249,731 | 0 | 4.69 | 3.79 | -0.90 | hold |
| TANG CAPITAL MANAGEMENT LLC | 4,218,829 | 4,321,547 | +102,718 | 5.06 | 3.57 | -1.49 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,192,005 | 4,212,005 | +20,000 | 2.02 | 1.75 | -0.26 | buy |
| Vestal Point Capital, LP | 2,300,000 | 4,000,000 | +1,700,000 | 2.02 | 3.65 | +1.63 | buy |
| Frazier Life Sciences Management, L.P. | 3,687,867 | 3,687,867 | 0 | 2.03 | 1.71 | -0.32 | hold |
| Capital World Investors | 3,227,620 | 3,374,064 | +146,444 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 1,990,588 | 2,150,527 | +159,939 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,050,000 | 1,419,792 | -630,208 | 0.04 | 0.03 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 1,338,568 | 1,299,503 | -39,065 | 3.02 | 4.54 | +1.52 | sell |
| STATE STREET CORP | 756,430 | 1,271,609 | +515,179 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 881,937 | 896,915 | +14,978 | 1.61 | 1.56 | -0.06 | buy |
| EMERALD ADVISERS, LLC | 643,897 | 835,988 | +192,091 | 0.32 | 0.37 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 806,271 | 830,984 | +24,713 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 806,973 | 723,678 | -83,295 | 2.27 | 1.98 | -0.29 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 529,365 | 650,980 | +121,615 | 0.33 | 0.39 | +0.06 | buy |
| Woodline Partners LP | 150,462 | 608,253 | +457,791 | 0.02 | 0.06 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 534,979 | 607,036 | +72,057 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 560,883 | 574,558 | +13,675 | 1.63 | 1.50 | -0.13 | buy |
| Saturn V Capital Management LP | 1,128,478 | 556,489 | -571,989 | 5.02 | 2.30 | -2.72 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 467,998 | 431,232 | -36,766 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 332,695 | 379,375 | +46,680 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 175,000 | 375,000 | +200,000 | 0.04 | 0.07 | +0.03 | buy |
| First Turn Management, LLC | 1,059,540 | 355,000 | -704,540 | 2.03 | 0.65 | -1.38 | sell |
| CITIGROUP INC | 286,064 | 305,504 | +19,440 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 337,985 | 303,864 | -34,121 | 3.15 | 2.33 | -0.81 | sell |
| MORGAN STANLEY | 338,584 | 297,402 | -41,182 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 180,000 | +180,000 | 0.00 | 0.11 | +0.11 | buy |
| Qube Research & Technologies Ltd | 29,589 | 178,608 | +149,019 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 219,277 | 154,522 | -64,755 | 2.76 | 1.54 | -1.21 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 122,960 | 135,552 | +12,592 | 0.04 | 0.04 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 212,888 | 134,041 | -78,847 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 18,822 | 127,249 | +108,427 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 84,023 | 117,923 | +33,900 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 78,682 | 115,992 | +37,310 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,594 | 110,720 | +126 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 135,600 | 105,611 | -29,989 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 62,704 | 95,704 | +33,000 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 100,061 | 89,929 | -10,132 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 46,000 | 82,000 | +36,000 | 0.50 | 0.82 | +0.32 | buy |
| BARCLAYS PLC | 12,965 | 67,222 | +54,257 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 54,026 | 66,423 | +12,397 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,755 | 54,468 | -6,287 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 62,507 | 52,694 | -9,813 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 53,228 | 50,279 | -2,949 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 43,830 | +43,830 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 13,406 | 43,429 | +30,023 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,016 | 43,296 | +40,280 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 42,450 | 40,020 | -2,430 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 63,122 | 38,322 | -24,800 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 28,939 | 34,723 | +5,784 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 31,873 | 33,305 | +1,432 | 0.14 | 0.13 | -0.00 | buy |
| EVOKE WEALTH, LLC | 15,373 | 32,363 | +16,990 | 0.27 | 0.01 | -0.26 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 26,968 | +26,968 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,197 | 26,950 | -1,247 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 25,749 | +25,749 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 3,530 | 24,322 | +20,792 | 0.02 | 0.16 | +0.14 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 10,704 | 22,949 | +12,245 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 22,610 | +22,610 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 22,590 | +6,320 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 22,454 | +22,454 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 22,289 | 22,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 15,858 | 21,918 | +6,060 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 21,380 | 20,660 | -720 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,489 | 20,627 | +138 | 0.00 | 0.00 | -0.00 | buy |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 18,338 | 18,338 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Paloma Partners Management Co | 0 | 17,924 | +17,924 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,486 | 17,821 | +4,335 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,932 | 15,622 | -310 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 0 | 15,112 | +15,112 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 48,911 | 14,906 | -34,005 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,437 | 14,902 | -535 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 14,280 | 14,557 | +277 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 12,020 | 14,143 | +2,123 | 0.03 | 0.03 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,415 | 13,321 | -94 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 10,841 | 13,255 | +2,414 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,189 | +13,189 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,352 | 13,117 | -12,235 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 12,354 | +12,354 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 11,488 | 0 | 0.07 | 0.06 | -0.01 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,855 | +10,855 | 0.00 | 0.00 | +0.00 | buy |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,733 | 9,964 | -28,769 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 4,958 | 8,286 | +3,328 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 6,380 | 6,650 | +270 | 0.00 | 0.00 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 4,380 | 4,365 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,731 | 3,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,759 | 2,853 | +94 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,215 | 2,084 | +869 | 0.00 | 0.00 | +0.00 | buy |
| 1620 INVESTMENT ADVISORS, INC. | 1,590 | 1,590 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,260 | 1,558 | +298 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,436 | 1,411 | -25 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,065 | 1,065 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,691 | 825 | -2,866 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 652 | 652 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Venturi Wealth Management, LLC | 0 | 410 | +410 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 350 | 323 | -27 | 0.00 | 0.00 | -0.00 | sell |