| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,728,985 | 6,728,985 | 0 | 5.70 | 4.61 | -1.09 | hold |
| TANG CAPITAL MANAGEMENT LLC | 4,941,798 | 5,041,798 | +100,000 | 2.82 | 2.36 | -0.46 | buy |
| Frazier Life Sciences Management, L.P. | 4,887,867 | 5,039,867 | +152,000 | 2.21 | 1.84 | -0.37 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,955,000 | 4,768,712 | -186,288 | 2.11 | 1.76 | -0.35 | sell |
| Capital World Investors | 3,177,587 | 3,177,587 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BlackRock, Inc. | 3,129,494 | 3,126,117 | -3,377 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,412,399 | 2,501,119 | +88,720 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 340,629 | 2,096,223 | +1,755,594 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 1,920,664 | 1,920,664 | 0 | 0.11 | 0.11 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 134,398 | 1,800,181 | +1,665,783 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 679,063 | 1,735,003 | +1,055,940 | 0.89 | 2.32 | +1.43 | buy |
| STATE STREET CORP | 1,349,539 | 1,575,496 | +225,957 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,832,171 | 1,363,378 | -468,793 | 4.24 | 2.40 | -1.83 | sell |
| EMERALD ADVISERS, LLC | 1,038,049 | 1,351,254 | +313,205 | 0.43 | 0.53 | +0.10 | buy |
| Octagon Capital Advisors LP | 1,273,333 | 1,273,333 | 0 | 3.16 | 2.42 | -0.74 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 554,958 | 1,158,457 | +603,499 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 941,212 | 928,671 | -12,541 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 768,972 | 917,975 | +149,003 | 0.53 | 0.58 | +0.05 | buy |
| Vestal Point Capital, LP | 4,675,000 | 750,000 | -3,925,000 | 2.78 | 0.41 | -2.37 | sell |
| Freestone Grove Partners LP | 0 | 704,448 | +704,448 | 0.00 | 0.06 | +0.06 | buy |
| Sio Capital Management, LLC | 0 | 683,819 | +683,819 | 0.00 | 2.11 | +2.11 | buy |
| Kynam Capital Management, LP | 0 | 606,171 | +606,171 | 0.00 | 0.55 | +0.55 | buy |
| Bank of New York Mellon Corp | 107,635 | 596,474 | +488,839 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 168,923 | 577,904 | +408,981 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 239,629 | 564,856 | +325,227 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 272,861 | 454,148 | +181,287 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 145,282 | 446,372 | +301,090 | 0.01 | 0.04 | +0.03 | buy |
| DAFNA Capital Management LLC | 581,757 | 422,731 | -159,026 | 1.82 | 1.27 | -0.54 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 294,198 | 393,339 | +99,141 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 119,622 | 370,773 | +251,151 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 366,966 | 364,409 | -2,557 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 352,152 | 350,723 | -1,429 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 97,248 | 325,435 | +228,187 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,496 | 321,967 | +208,471 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 286,875 | +286,875 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 299,194 | 280,656 | -18,538 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 200,991 | +160,128 | 0.00 | 0.01 | +0.01 | buy |
| F/m Investments LLC | 182,262 | 199,204 | +16,942 | 0.07 | 0.09 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 292,593 | 197,335 | -95,258 | 0.01 | 0.01 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 155,961 | 176,583 | +20,622 | 0.07 | 0.08 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 154,522 | 154,522 | 0 | 0.21 | 0.19 | -0.02 | hold |
| RAYMOND JAMES FINANCIAL INC | 101,035 | 149,306 | +48,271 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 143,561 | +143,561 | 0.00 | 0.07 | +0.07 | buy |
| Caption Management, LLC | 0 | 141,422 | +141,422 | 0.00 | 0.10 | +0.10 | buy |
| Susquehanna Portfolio Strategies, LLC | 92,259 | 128,011 | +35,752 | 0.02 | 0.02 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 132,900 | 126,052 | -6,848 | 0.00 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 0 | 125,000 | +125,000 | 0.00 | 0.47 | +0.47 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 148,927 | 107,283 | -41,644 | 0.05 | 0.03 | -0.02 | sell |
| FMR LLC | 133,566 | 92,368 | -41,198 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 68,539 | 79,758 | +11,219 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 67,000 | 67,000 | 0 | 0.75 | 0.62 | -0.14 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 73,343 | 65,960 | -7,383 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 50,761 | 63,243 | +12,482 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 46,901 | 57,790 | +10,889 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 386,790 | 56,770 | -330,020 | 1.41 | 0.14 | -1.27 | sell |
| Russell Investments Group, Ltd. | 53,069 | 56,196 | +3,127 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 13,333 | 55,878 | +42,545 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 54,376 | 52,798 | -1,578 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 131 | 51,775 | +51,644 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 0 | 48,500 | +48,500 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 173,209 | 45,444 | -127,765 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 47,413 | 44,606 | -2,807 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 41,620 | +41,620 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 41,555 | +41,555 | 0.00 | 0.09 | +0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 33,380 | 38,032 | +4,652 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,324 | 37,244 | +11,920 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 54,910 | 36,663 | -18,247 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 945,125 | 35,449 | -909,676 | 0.00 | 0.00 | -0.00 | sell |
| EVOKE WEALTH, LLC | 32,181 | 32,053 | -128 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 28,474 | 30,255 | +1,781 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 26,924 | +26,924 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,511 | 24,386 | +21,875 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,202 | 23,954 | +19,752 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 21,915 | 23,361 | +1,446 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 21,421 | +21,421 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 64,294 | 21,372 | -42,922 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 25,720 | 21,100 | -4,620 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 23,218 | 20,759 | -2,459 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,964 | 20,512 | -2,452 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 93,400 | 20,400 | -73,000 | 0.53 | 0.08 | -0.45 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,864 | 19,980 | +2,116 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 19,022 | 18,422 | -600 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 0 | 17,213 | +17,213 | 0.00 | 0.08 | +0.08 | buy |
| DRW Securities, LLC | 0 | 16,775 | +16,775 | 0.00 | 0.01 | +0.01 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | 16,711 | 0 | 0.09 | 0.09 | -0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 0 | 15,678 | +15,678 | 0.00 | 0.09 | +0.09 | buy |
| Quantinno Capital Management LP | 0 | 14,158 | +14,158 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 13,600 | +13,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,626 | 13,288 | -1,338 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 17,671 | 12,919 | -4,752 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 10,020 | 12,613 | +2,593 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 11,896 | +11,896 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 11,568 | +11,568 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,756 | 11,172 | +1,416 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 10,900 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 28,884 | 10,686 | -18,198 | 0.01 | 0.01 | -0.00 | sell |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 10,000 | 10,000 | 0 | 0.02 | 0.01 | -0.01 | hold |