| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 340,629 | 2,096,223 | +1,755,594 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 134,398 | 1,800,181 | +1,665,783 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 679,063 | 1,735,003 | +1,055,940 | 0.89 | 2.32 | +1.43 | buy |
| Freestone Grove Partners LP | 0 | 704,448 | +704,448 | 0.00 | 0.06 | +0.06 | buy |
| Sio Capital Management, LLC | 0 | 683,819 | +683,819 | 0.00 | 2.11 | +2.11 | buy |
| Kynam Capital Management, LP | 0 | 606,171 | +606,171 | 0.00 | 0.55 | +0.55 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 554,958 | 1,158,457 | +603,499 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 107,635 | 596,474 | +488,839 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 168,923 | 577,904 | +408,981 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 239,629 | 564,856 | +325,227 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 1,038,049 | 1,351,254 | +313,205 | 0.43 | 0.53 | +0.10 | buy |
| Schonfeld Strategic Advisors LLC | 145,282 | 446,372 | +301,090 | 0.01 | 0.04 | +0.03 | buy |
| Jefferies Financial Group Inc. | 0 | 286,875 | +286,875 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 119,622 | 370,773 | +251,151 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 97,248 | 325,435 | +228,187 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,349,539 | 1,575,496 | +225,957 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,496 | 321,967 | +208,471 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 272,861 | 454,148 | +181,287 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 200,991 | +160,128 | 0.00 | 0.01 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 4,887,867 | 5,039,867 | +152,000 | 2.21 | 1.84 | -0.37 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 768,972 | 917,975 | +149,003 | 0.53 | 0.58 | +0.05 | buy |
| SummitTX Capital, L.P. | 0 | 143,561 | +143,561 | 0.00 | 0.07 | +0.07 | buy |
| Caption Management, LLC | 0 | 141,422 | +141,422 | 0.00 | 0.10 | +0.10 | buy |
| Blue Owl Capital Holdings LP | 0 | 125,000 | +125,000 | 0.00 | 0.47 | +0.47 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,941,798 | 5,041,798 | +100,000 | 2.82 | 2.36 | -0.46 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 294,198 | 393,339 | +99,141 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,412,399 | 2,501,119 | +88,720 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 131 | 51,775 | +51,644 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 0 | 48,500 | +48,500 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 101,035 | 149,306 | +48,271 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 13,333 | 55,878 | +42,545 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 41,620 | +41,620 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 41,555 | +41,555 | 0.00 | 0.09 | +0.09 | buy |
| Susquehanna Portfolio Strategies, LLC | 92,259 | 128,011 | +35,752 | 0.02 | 0.02 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 26,924 | +26,924 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,511 | 24,386 | +21,875 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 21,421 | +21,421 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 155,961 | 176,583 | +20,622 | 0.07 | 0.08 | +0.01 | buy |
| Legal & General Group Plc | 4,202 | 23,954 | +19,752 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 17,213 | +17,213 | 0.00 | 0.08 | +0.08 | buy |
| F/m Investments LLC | 182,262 | 199,204 | +16,942 | 0.07 | 0.09 | +0.02 | buy |
| DRW Securities, LLC | 0 | 16,775 | +16,775 | 0.00 | 0.01 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 15,678 | +15,678 | 0.00 | 0.09 | +0.09 | buy |
| Quantinno Capital Management LP | 0 | 14,158 | +14,158 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 13,600 | +13,600 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 50,761 | 63,243 | +12,482 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,324 | 37,244 | +11,920 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 11,896 | +11,896 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 11,568 | +11,568 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 68,539 | 79,758 | +11,219 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 10,900 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 46,901 | 57,790 | +10,889 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 5,200 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 4,662 | +4,662 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 33,380 | 38,032 | +4,652 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 4,545 | +4,545 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,041 | 7,794 | +3,753 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 53,069 | 56,196 | +3,127 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,020 | 12,613 | +2,593 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,864 | 19,980 | +2,116 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 28,474 | 30,255 | +1,781 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,184 | 8,693 | +1,509 | 0.03 | 0.03 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 21,915 | 23,361 | +1,446 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,756 | 11,172 | +1,416 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 971 | +971 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,392 | 2,232 | +840 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 777 | +777 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 166 | 690 | +524 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 253 | +253 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 533 | 647 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 45 | 147 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 94 | 133 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,921 | 1,946 | +25 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 449 | 461 | +12 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 0 | 10 | +10 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 0 | 5 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,731 | 3,731 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | 16,711 | 0 | 0.09 | 0.09 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 160 | 160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 91 | 91 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital World Investors | 3,177,587 | 3,177,587 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Parkside Financial Bank & Trust | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 154 | 154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 6,728,985 | 6,728,985 | 0 | 5.70 | 4.61 | -1.09 | hold |
| Birchview Capital, LP | 67,000 | 67,000 | 0 | 0.75 | 0.62 | -0.14 | hold |
| Parallel Advisors, LLC | 1,423 | 1,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 1,024 | 1,024 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 1,324 | 1,324 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NAN FUNG TRINITY (HK) Ltd | 154,522 | 154,522 | 0 | 0.21 | 0.19 | -0.02 | hold |
| Woodline Partners LP | 1,920,664 | 1,920,664 | 0 | 0.11 | 0.11 | -0.00 | hold |
| Octagon Capital Advisors LP | 1,273,333 | 1,273,333 | 0 | 3.16 | 2.42 | -0.74 | hold |
| 1620 INVESTMENT ADVISORS, INC. | 1,590 | 1,590 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 10,000 | 10,000 | 0 | 0.02 | 0.01 | -0.01 | hold |