| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 2,916,667 | 4,092,731 | +1,176,064 | 2.96 | 3.44 | +0.48 | buy |
| Frazier Life Sciences Management, L.P. | 3,238,859 | 3,622,294 | +383,435 | 2.07 | 2.37 | +0.30 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,420,851 | 2,684,005 | +263,154 | 1.26 | 1.49 | +0.23 | buy |
| Nan Fung Group Holdings Ltd | 234,573 | 304,277 | +69,704 | 1.83 | 2.32 | +0.49 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 104,668 | 110,922 | +6,254 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 65,286 | 69,844 | +4,558 | 0.14 | 0.15 | +0.01 | buy |
| Saturn V Capital Management LP | 1,810,246 | 1,807,563 | -2,683 | 7.30 | 8.48 | +1.18 | sell |
| DAFNA Capital Management LLC | 605,532 | 601,032 | -4,500 | 1.81 | 1.76 | -0.05 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,034,623 | 1,028,568 | -6,055 | 0.13 | 0.15 | +0.02 | sell |
| Belvedere Trading LLC | 11,054 | 4,170 | -6,884 | 0.00 | 0.00 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 140,200 | 51,500 | -88,700 | 0.01 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 228,934 | 111,734 | -117,200 | 0.82 | 0.42 | -0.40 | sell |
| Affinity Asset Advisors, LLC | 278,292 | 125,969 | -152,323 | 0.88 | 0.31 | -0.57 | sell |
| Opaleye Management Inc. | 500,000 | 150,000 | -350,000 | 1.57 | 0.49 | -1.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,056,691 | 705,000 | -351,691 | 0.02 | 0.02 | -0.01 | sell |