| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 2,916,667 | 4,092,731 | +1,176,064 | 2.96 | 3.44 | +0.48 | buy |
| Frazier Life Sciences Management, L.P. | 3,238,859 | 3,622,294 | +383,435 | 2.07 | 2.37 | +0.30 | buy |
| Woodline Partners LP | 0 | 346,863 | +346,863 | 0.00 | 0.05 | +0.05 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,420,851 | 2,684,005 | +263,154 | 1.26 | 1.50 | +0.24 | buy |
| MORGAN STANLEY | 209,928 | 452,434 | +242,506 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 582,905 | 716,964 | +134,059 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 521,891 | 630,048 | +108,157 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 459,346 | 537,102 | +77,756 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 234,573 | 304,277 | +69,704 | 1.83 | 2.32 | +0.49 | buy |
| TWO SIGMA INVESTMENTS, LP | 103,794 | 165,759 | +61,965 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 275,218 | 326,496 | +51,278 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 1,030,000 | 1,080,000 | +50,000 | 0.25 | 0.21 | -0.04 | buy |
| VANGUARD GROUP INC | 1,732,489 | 1,781,419 | +48,930 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 41,365 | +41,365 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 58,378 | 97,830 | +39,452 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 4,215 | 42,531 | +38,316 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 127,866 | 165,000 | +37,134 | 0.16 | 0.22 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 32,591 | +32,591 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 174,322 | 202,522 | +28,200 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 84,309 | 100,693 | +16,384 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,794 | 26,971 | +16,177 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,154 | 80,451 | +15,297 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 14,772 | +14,772 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 13,477 | +13,477 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 10,260 | +10,260 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 9,790 | +9,790 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,153 | 29,063 | +6,910 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 131,147 | 137,817 | +6,670 | 0.02 | 0.02 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 104,668 | 110,922 | +6,254 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,690 | 9,263 | +5,573 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 276,918 | 281,909 | +4,991 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 22,266 | 27,104 | +4,838 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 32,684 | 37,517 | +4,833 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 65,286 | 69,844 | +4,558 | 0.14 | 0.15 | +0.01 | buy |
| MetLife Investment Management, LLC | 12,495 | 16,776 | +4,281 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,981 | +3,981 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 41,895 | 45,361 | +3,466 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,431 | 10,831 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 12,290 | 15,389 | +3,099 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,627 | 12,897 | +2,270 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,961 | 21,198 | +2,237 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,369 | 12,539 | +2,170 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 10,670 | 11,905 | +1,235 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,714 | 3,482 | +768 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 1,952 | 2,596 | +644 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,353 | 1,820 | +467 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,344 | 11,529 | +185 | 0.00 | 0.00 | +0.00 | buy |
| Garner Asset Management Corp | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 81 | 198 | +117 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,468 | 2,468 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,440,345 | 3,440,345 | 0 | 4.67 | 3.89 | -0.78 | hold |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 40,000 | 40,000 | 0 | 0.33 | 0.38 | +0.06 | hold |
| Vivo Capital, LLC | 856,008 | 856,008 | 0 | 0.90 | 0.86 | -0.04 | hold |
| TCG Crossover Management, LLC | 3,395,495 | 3,395,495 | 0 | 4.81 | 4.61 | -0.20 | hold |
| Red Tortoise LLC | 187 | 187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 4,339 | 4,339 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Newbridge Financial Services Group, Inc. | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 546 | 519 | -27 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,959 | 9,914 | -45 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 2,324 | 2,093 | -231 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 11,879 | 11,544 | -335 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,434 | 5,096 | -338 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 32,410 | 30,010 | -2,400 | 0.00 | 0.00 | +0.00 | sell |
| Saturn V Capital Management LP | 1,810,246 | 1,807,563 | -2,683 | 7.30 | 8.48 | +1.18 | sell |
| Quantbot Technologies LP | 3,200 | 0 | -3,200 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 605,532 | 601,032 | -4,500 | 1.81 | 1.76 | -0.05 | sell |
| NATIXIS | 5,000 | 0 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,034,623 | 1,028,568 | -6,055 | 0.13 | 0.15 | +0.02 | sell |
| FMR LLC | 57,566 | 50,970 | -6,596 | 0.00 | 0.00 | +0.00 | sell |
| Belvedere Trading LLC | 11,054 | 4,170 | -6,884 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 8,810 | 0 | -8,810 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 10,200 | 0 | -10,200 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,738 | 0 | -10,738 | 0.01 | 0.00 | -0.01 | sell |
| STRS OHIO | 10,800 | 0 | -10,800 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 10,807 | 0 | -10,807 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 13,955 | 0 | -13,955 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,000 | 51,100 | -22,900 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 22,941 | 0 | -22,941 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 23,250 | 0 | -23,250 | 0.01 | 0.00 | -0.01 | sell |
| ALPS ADVISORS INC | 25,338 | 0 | -25,338 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 115,282 | 88,763 | -26,519 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 69,100 | 42,300 | -26,800 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 30,790 | 0 | -30,790 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 34,393 | 0 | -34,393 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 37,754 | 0 | -37,754 | 0.05 | 0.00 | -0.05 | sell |
| CIBC WORLD MARKETS CORP | 50,000 | 0 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 51,524 | 0 | -51,524 | 0.00 | 0.00 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 140,200 | 51,500 | -88,700 | 0.01 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 228,934 | 111,734 | -117,200 | 0.82 | 0.42 | -0.40 | sell |
| GOLDMAN SACHS GROUP INC | 208,812 | 87,099 | -121,713 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 142,692 | 0 | -142,692 | 0.51 | 0.00 | -0.51 | sell |
| CITADEL ADVISORS LLC | 928,502 | 783,698 | -144,804 | 0.01 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 278,292 | 125,969 | -152,323 | 0.88 | 0.31 | -0.57 | sell |
| JPMORGAN CHASE & CO | 270,941 | 26,792 | -244,149 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 500,000 | 150,000 | -350,000 | 1.57 | 0.49 | -1.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,056,691 | 705,000 | -351,691 | 0.02 | 0.02 | -0.01 | sell |