| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 3,687,867 | 4,887,867 | +1,200,000 | 1.71 | 1.72 | +0.01 | buy |
| Vestal Point Capital, LP | 4,000,000 | 4,770,000 | +770,000 | 3.65 | 2.40 | -1.26 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,212,005 | 4,913,012 | +701,007 | 1.56 | 1.42 | -0.14 | buy |
| Woodline Partners LP | 608,253 | 1,288,401 | +680,148 | 0.06 | 0.07 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,321,547 | 4,893,847 | +572,300 | 3.57 | 2.74 | -0.83 | buy |
| GREAT POINT PARTNERS LLC | 1,299,503 | 1,787,003 | +487,500 | 4.43 | 7.13 | +2.70 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 431,232 | 805,445 | +374,213 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 180,000 | 315,700 | +135,700 | 0.11 | 0.11 | +0.00 | buy |
| DAFNA Capital Management LLC | 723,678 | 811,678 | +88,000 | 1.98 | 1.75 | -0.23 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 574,558 | 612,173 | +37,615 | 1.50 | 1.16 | -0.34 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 135,552 | 172,693 | +37,141 | 0.12 | 0.12 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 14,143 | 35,843 | +21,700 | 0.03 | 0.06 | +0.04 | buy |
| PDT Partners, LLC | 22,454 | 35,201 | +12,747 | 0.02 | 0.03 | +0.00 | buy |
| Rafferty Asset Management, LLC | 43,830 | 54,466 | +10,636 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,286 | 10,329 | +2,043 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 835,988 | 836,050 | +62 | 0.37 | 0.27 | -0.10 | buy |
| EntryPoint Capital, LLC | 24,322 | 11,509 | -12,813 | 0.16 | 0.04 | -0.12 | sell |
| Birchview Capital, LP | 82,000 | 67,000 | -15,000 | 0.82 | 0.46 | -0.36 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 650,980 | 549,688 | -101,292 | 0.39 | 0.28 | -0.11 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,419,792 | 300,000 | -1,119,792 | 0.03 | 0.00 | -0.02 | sell |