| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,249,731 | 6,249,731 | 0 | 3.79 | 3.63 | -0.16 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,212,005 | 4,913,012 | +701,007 | 1.75 | 1.54 | -0.21 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,321,547 | 4,893,847 | +572,300 | 3.57 | 2.74 | -0.83 | buy |
| Frazier Life Sciences Management, L.P. | 3,687,867 | 4,887,867 | +1,200,000 | 1.71 | 1.72 | +0.01 | buy |
| Vestal Point Capital, LP | 4,000,000 | 4,770,000 | +770,000 | 3.65 | 2.40 | -1.26 | buy |
| Capital World Investors | 3,374,064 | 3,374,064 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 3,062,319 | 2,863,996 | -198,323 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,150,527 | 2,255,243 | +104,716 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,299,503 | 1,787,003 | +487,500 | 4.54 | 7.13 | +2.59 | buy |
| STATE STREET CORP | 1,271,609 | 1,390,863 | +119,254 | 0.00 | 0.00 | -0.00 | buy |
| Octagon Capital Advisors LP | 0 | 1,370,000 | +1,370,000 | 0.00 | 1.97 | +1.97 | buy |
| Woodline Partners LP | 608,253 | 1,288,401 | +680,148 | 0.06 | 0.07 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 992,803 | +992,803 | 0.00 | 2.11 | +2.11 | buy |
| EMERALD ADVISERS, LLC | 835,988 | 836,050 | +62 | 0.37 | 0.27 | -0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 830,984 | 822,352 | -8,632 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 723,678 | 811,678 | +88,000 | 1.98 | 1.75 | -0.23 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 431,232 | 805,445 | +374,213 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 607,036 | 696,037 | +89,001 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 574,558 | 612,173 | +37,615 | 1.50 | 1.16 | -0.34 | buy |
| Saturn V Capital Management LP | 556,489 | 556,489 | 0 | 2.30 | 1.85 | -0.46 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 650,980 | 549,688 | -101,292 | 0.39 | 0.28 | -0.11 | sell |
| Jefferies Financial Group Inc. | 375,000 | 375,000 | 0 | 0.07 | 0.04 | -0.04 | hold |
| UBS Group AG | 43,429 | 374,631 | +331,202 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 379,375 | 366,170 | -13,205 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 134,041 | 327,673 | +193,632 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 305,504 | 327,296 | +21,792 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 180,000 | 315,700 | +135,700 | 0.11 | 0.11 | +0.00 | buy |
| Rosalind Advisors, Inc. | 303,864 | 303,864 | 0 | 2.33 | 1.39 | -0.95 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,419,792 | 300,000 | -1,119,792 | 0.03 | 0.00 | -0.02 | sell |
| MORGAN STANLEY | 297,402 | 289,515 | -7,887 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 267,743 | +267,743 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 135,552 | 172,693 | +37,141 | 0.04 | 0.04 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 154,522 | 154,522 | 0 | 1.54 | 1.12 | -0.42 | hold |
| CITADEL ADVISORS LLC | 127,249 | 136,493 | +9,244 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 115,992 | 133,572 | +17,580 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 178,608 | 126,132 | -52,476 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 117,923 | 122,863 | +4,940 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 14,906 | 117,978 | +103,072 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 52,694 | 110,050 | +57,356 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,720 | 100,348 | -10,372 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 105,611 | 98,547 | -7,064 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 95,704 | 95,704 | 0 | 0.02 | 0.01 | -0.01 | hold |
| FMR LLC | 66,423 | 82,005 | +15,582 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 68,526 | 80,319 | +11,793 | 0.02 | 0.01 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 74,827 | +74,827 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 89,929 | 73,286 | -16,643 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 71,896 | +71,896 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 69,397 | +69,397 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 67,222 | 68,062 | +840 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 82,000 | 67,000 | -15,000 | 0.82 | 0.46 | -0.36 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 54,468 | 65,748 | +11,280 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 43,830 | 54,466 | +10,636 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 53,382 | +53,382 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,279 | 51,156 | +877 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,863 | 40,863 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 14,143 | 35,843 | +21,700 | 0.03 | 0.06 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 21,918 | 35,841 | +13,923 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 22,454 | 35,201 | +12,747 | 0.02 | 0.03 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,084 | 35,125 | +33,041 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 33,305 | 33,305 | 0 | 0.13 | 0.10 | -0.03 | hold |
| EVOKE WEALTH, LLC | 32,363 | 32,363 | 0 | 0.01 | 0.01 | -0.00 | hold |
| XTX Topco Ltd | 0 | 31,573 | +31,573 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,821 | 29,178 | +11,357 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 38,322 | 22,822 | -15,500 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,590 | 21,386 | -1,204 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 22,610 | 21,260 | -1,350 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 20,660 | 20,804 | +144 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 3,500 | 20,227 | +16,727 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,622 | 20,165 | +4,543 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 22,289 | 19,152 | -3,137 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 19,022 | 19,022 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 15,112 | 17,700 | +2,588 | 0.02 | 0.02 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,855 | 17,204 | +6,349 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 20,627 | 16,945 | -3,682 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 14,557 | 15,640 | +1,083 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 13,189 | 14,508 | +1,319 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,902 | 14,193 | -709 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,117 | 13,839 | +722 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 26,950 | 13,463 | -13,487 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,321 | 12,390 | -931 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 0 | 11,906 | +11,906 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 11,579 | +11,579 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 24,322 | 11,509 | -12,813 | 0.16 | 0.04 | -0.12 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 11,488 | 11,488 | 0 | 0.06 | 0.05 | -0.02 | hold |
| SYON CAPITAL LLC | 0 | 10,993 | +10,993 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 10,762 | +10,762 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 10,479 | +10,479 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 10,360 | +10,360 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,286 | 10,329 | +2,043 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 34,723 | 10,072 | -24,651 | 0.00 | 0.00 | -0.00 | sell |
| Choate Investment Advisors | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,964 | 9,964 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 6,650 | 8,144 | +1,494 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 825 | 6,327 | +5,502 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 43,296 | 6,252 | -37,044 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 5,188 | +5,188 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4,365 | 4,339 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,731 | 3,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,853 | 2,511 | -342 | 0.00 | 0.00 | -0.00 | sell |