| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 6,728,985 | 6,728,985 | 0 | 4.61 | 5.37 | +0.75 | hold |
| Frazier Life Sciences Management, L.P. | 5,039,867 | 5,039,867 | 0 | 1.84 | 2.19 | +0.35 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,768,712 | 4,768,712 | 0 | 1.76 | 1.92 | +0.16 | hold |
| TANG CAPITAL MANAGEMENT LLC | 5,041,798 | 4,573,530 | -468,268 | 2.36 | 3.65 | +1.28 | sell |
| BlackRock, Inc. | 3,126,117 | 3,754,148 | +628,031 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,096,223 | 2,896,666 | +800,443 | 0.02 | 0.03 | +0.01 | buy |
| Capital World Investors | 3,177,587 | 2,808,583 | -369,004 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 2,501,119 | 2,509,020 | +7,901 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,363,378 | 2,427,118 | +1,063,740 | 2.40 | 5.67 | +3.27 | buy |
| Point72 Asset Management, L.P. | 0 | 2,283,766 | +2,283,766 | 0.00 | 0.06 | +0.06 | buy |
| Woodline Partners LP | 1,920,664 | 1,921,092 | +428 | 0.11 | 0.12 | +0.01 | buy |
| STATE STREET CORP | 1,575,496 | 1,911,691 | +336,195 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 750,000 | 1,890,000 | +1,140,000 | 0.41 | 1.12 | +0.71 | buy |
| Kynam Capital Management, LP | 606,171 | 1,810,954 | +1,204,783 | 0.55 | 1.90 | +1.35 | buy |
| Parkman Healthcare Partners LLC | 1,735,003 | 1,768,508 | +33,505 | 2.32 | 2.72 | +0.40 | buy |
| EMERALD ADVISERS, LLC | 1,351,254 | 1,340,495 | -10,759 | 0.53 | 0.67 | +0.14 | sell |
| Octagon Capital Advisors LP | 1,273,333 | 1,273,333 | 0 | 2.42 | 2.57 | +0.15 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,158,457 | 1,171,755 | +13,298 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 928,671 | 944,077 | +15,406 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 917,975 | 855,461 | -62,514 | 0.58 | 0.67 | +0.10 | sell |
| GOLDMAN SACHS GROUP INC | 1,800,181 | 835,304 | -964,877 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 0 | 800,000 | +800,000 | 0.00 | 0.32 | +0.32 | buy |
| BARCLAYS PLC | 577,904 | 700,573 | +122,669 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 564,856 | 700,228 | +135,372 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 596,474 | 695,175 | +98,701 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 685,632 | +685,632 | 0.00 | 3.59 | +3.59 | buy |
| Freestone Grove Partners LP | 704,448 | 633,019 | -71,429 | 0.06 | 0.07 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 364,409 | 389,813 | +25,404 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 382,400 | +382,400 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 454,148 | 371,993 | -82,155 | 0.00 | 0.00 | +0.00 | sell |
| Blue Owl Capital Holdings LP | 125,000 | 360,000 | +235,000 | 0.47 | 1.79 | +1.32 | buy |
| DAFNA Capital Management LLC | 422,731 | 356,802 | -65,929 | 1.27 | 1.34 | +0.07 | sell |
| NORTHERN TRUST CORP | 350,723 | 351,973 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 200,991 | 351,305 | +150,314 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 176,583 | 341,819 | +165,236 | 0.08 | 0.19 | +0.11 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 321,967 | 324,369 | +2,402 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 446,372 | 305,880 | -140,492 | 0.04 | 0.02 | -0.01 | sell |
| HRT FINANCIAL LP | 0 | 287,052 | +287,052 | 0.00 | 0.01 | +0.01 | buy |
| Atom Investors LP | 0 | 276,113 | +276,113 | 0.00 | 0.35 | +0.35 | buy |
| F/m Investments LLC | 199,204 | 236,690 | +37,486 | 0.09 | 0.15 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 165,151 | +165,151 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 154,522 | 154,522 | 0 | 0.19 | 0.20 | +0.01 | hold |
| RAYMOND JAMES FINANCIAL INC | 149,306 | 129,517 | -19,789 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 126,052 | 122,379 | -3,673 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 141,422 | 117,907 | -23,515 | 0.10 | 0.08 | -0.02 | sell |
| FMR LLC | 92,368 | 111,807 | +19,439 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 197,335 | 109,391 | -87,944 | 0.01 | 0.01 | -0.00 | sell |
| Nuveen, LLC | 79,758 | 107,129 | +27,371 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 90,742 | +90,742 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 63,243 | 77,864 | +14,621 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 393,339 | 71,895 | -321,444 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 57,790 | 65,593 | +7,803 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 55,878 | 59,147 | +3,269 | 0.01 | 0.02 | +0.01 | buy |
| Birchview Capital, LP | 67,000 | 57,000 | -10,000 | 0.62 | 0.54 | -0.08 | sell |
| Russell Investments Group, Ltd. | 56,196 | 56,249 | +53 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 37,244 | 56,014 | +18,770 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 48,500 | 54,900 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 51,775 | 52,190 | +415 | 0.04 | 0.05 | +0.01 | buy |
| SG Americas Securities, LLC | 41,620 | 48,030 | +6,410 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 52,798 | 47,391 | -5,407 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 38,032 | 44,082 | +6,050 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 41,504 | +41,504 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,693 | 40,414 | +31,721 | 0.03 | 0.18 | +0.15 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,020 | 40,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITADEL ADVISORS LLC | 0 | 37,761 | +37,761 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 35,119 | +35,119 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 30,255 | 35,091 | +4,836 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 35,449 | 34,929 | -520 | 0.00 | 0.00 | +0.00 | sell |
| EVOKE WEALTH, LLC | 32,053 | 31,841 | -212 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 36,663 | 31,608 | -5,055 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 30,939 | +30,939 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 14,158 | 29,156 | +14,998 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,386 | 28,410 | +4,024 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 13,600 | 27,722 | +14,122 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 26,508 | +26,508 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 44,606 | 24,666 | -19,940 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 12,613 | 24,392 | +11,779 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 23,954 | 23,818 | -136 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 0 | 23,370 | +23,370 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,980 | 23,118 | +3,138 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 23,361 | 21,937 | -1,424 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 21,688 | 21,688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,512 | 21,624 | +1,112 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 20,400 | 20,400 | 0 | 0.08 | 0.07 | -0.01 | hold |
| ExodusPoint Capital Management, LP | 0 | 20,061 | +20,061 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 20,759 | 19,454 | -1,305 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,545 | 17,868 | +13,323 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 17,446 | +17,446 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | 16,711 | 0 | 0.09 | 0.11 | +0.02 | hold |
| Bleakley Financial Group, LLC | 0 | 15,976 | +15,976 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,960 | 15,923 | -50,037 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 13,110 | +13,110 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 12,919 | 12,919 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rathbones Group PLC | 18,422 | 12,272 | -6,150 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 11,896 | 11,897 | +1 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,288 | 11,823 | -1,465 | 0.00 | 0.00 | +0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 15,678 | 11,424 | -4,254 | 0.09 | 0.48 | +0.39 | sell |
| Police & Firemen's Retirement System of New Jersey | 11,172 | 11,172 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Magnetar Financial LLC | 26,924 | 10,938 | -15,986 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 10,900 | 10,900 | 0 | 0.00 | 0.00 | +0.00 | hold |