| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 1,733,471 | 2,257,106 | +523,635 | 0.48 | 0.62 | +0.13 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,231,414 | 1,730,866 | +499,452 | 0.54 | 0.89 | +0.35 | buy |
| BIT Capital GmbH | 155,000 | 574,000 | +419,000 | 0.01 | 0.04 | +0.02 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 325,019 | 436,726 | +111,707 | 0.04 | 0.06 | +0.02 | buy |
| Simplify Asset Management Inc. | 350,000 | 450,543 | +100,543 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 2,019,326 | 2,030,927 | +11,601 | 0.98 | 0.97 | -0.01 | buy |
| Total Clarity Wealth Management, Inc. | 27,000 | 31,795 | +4,795 | 0.01 | 0.01 | +0.00 | buy |
| FNY Investment Advisers, LLC | 9,951 | 8,500 | -1,451 | 0.01 | 0.01 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 8,928,149 | 8,425,065 | -503,084 | 0.31 | 0.26 | -0.04 | sell |
| Eversept Partners, LP | 4,987,499 | 4,182,785 | -804,714 | 0.46 | 0.45 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 3,405,757 | 2,284,819 | -1,120,938 | 1.37 | 0.90 | -0.47 | sell |