| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| B Group, Inc. | 4,500,000 | 11,414,285 | +6,914,285 | 7.84 | 14.81 | +6.97 | buy |
| GOLDMAN SACHS GROUP INC | 557,565 | 5,373,951 | +4,816,386 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 6,911,237 | 11,510,320 | +4,599,083 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 3,405,757 | +3,405,757 | 0.00 | 1.46 | +1.46 | buy |
| FEDERATED HERMES, INC. | 0 | 3,136,607 | +3,136,607 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 325,367 | 3,270,845 | +2,945,478 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 2,904,911 | +2,904,911 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 2,754,403 | +2,754,403 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.12 | +0.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 294,486 | 2,103,353 | +1,808,867 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 184,100 | 1,733,471 | +1,549,371 | 0.09 | 0.52 | +0.43 | buy |
| Propel Bio Management, LLC | 0 | 1,115,000 | +1,115,000 | 0.00 | 1.26 | +1.26 | buy |
| UBS Group AG | 247,754 | 1,166,951 | +919,197 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 1,300,031 | 2,019,326 | +719,295 | 0.79 | 0.98 | +0.19 | buy |
| Octagon Capital Advisors LP | 9,567,898 | 10,276,317 | +708,419 | 2.81 | 1.99 | -0.82 | buy |
| FRANKLIN RESOURCES INC | 5,092,562 | 5,785,189 | +692,627 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 662,900 | +662,900 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 664,087 | 1,231,414 | +567,327 | 0.36 | 0.54 | +0.18 | buy |
| ORBIMED ADVISORS LLC | 1,871,420 | 2,333,000 | +461,580 | 0.09 | 0.09 | -0.00 | buy |
| MORGAN STANLEY | 4,142,446 | 4,551,533 | +409,087 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 0 | 350,000 | +350,000 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 325,019 | +325,019 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 2,004,845 | 2,264,845 | +260,000 | 0.35 | 0.24 | -0.11 | buy |
| Brevan Howard Capital Management LP | 0 | 214,821 | +214,821 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 211,882 | +211,882 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 189,261 | +189,261 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 21,669 | 204,590 | +182,921 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 10,540,334 | 10,689,452 | +149,118 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 148,970 | +148,970 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 133,131 | +133,131 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 0 | 105,832 | +105,832 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 88,000 | +88,000 | 0.00 | 0.14 | +0.14 | buy |
| EntryPoint Capital, LLC | 0 | 79,495 | +79,495 | 0.00 | 0.04 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 76,000 | +76,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 343,686 | 410,761 | +67,075 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,025 | 53,842 | +52,817 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 51,874 | +51,874 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 43,730 | +43,730 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 70,710 | 111,410 | +40,700 | 0.02 | 0.02 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,648 | 169,648 | +37,000 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 52,281 | 87,704 | +35,423 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 31,400 | +31,400 | 0.00 | 0.01 | +0.01 | buy |
| Vontobel Holding Ltd. | 20,000 | 45,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 11,231 | 33,146 | +21,915 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 17,441 | +17,441 | 0.00 | 0.07 | +0.07 | buy |
| CHOREO, LLC | 0 | 15,743 | +15,743 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 15,400 | +15,400 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 15,346 | +15,346 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 13,125 | +13,125 | 0.00 | 0.00 | +0.00 | buy |
| RFG Advisory, LLC | 0 | 11,750 | +11,750 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 15,000 | 17,000 | +2,000 | 0.01 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 16,072 | 16,454 | +382 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 381 | +381 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | 4,500,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 27,640 | 27,640 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | 7,124,116 | 0 | 0.17 | 0.13 | -0.04 | hold |
| Bank of New York Mellon Corp | 12,912 | 12,912 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FNY Investment Advisers, LLC | 9,951 | 9,951 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ikarian Capital, LLC | 274,978 | 274,978 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Avion Wealth | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artia Global Partners LP | 1,992,367 | 1,992,367 | 0 | 0.75 | 0.79 | +0.03 | hold |
| Boxer Capital Management, LLC | 4,799,875 | 4,799,875 | 0 | 2.47 | 1.10 | -1.37 | hold |
| Cetera Investment Advisers | 10,512 | 10,506 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,650 | 16,500 | -150 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 283,147 | 280,650 | -2,497 | 0.00 | 0.00 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 29,935 | 27,000 | -2,935 | 0.02 | 0.01 | -0.01 | sell |
| BlackRock, Inc. | 1,879,319 | 1,876,340 | -2,979 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 14,891 | 11,500 | -3,391 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 643,997 | 636,197 | -7,800 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 11,870 | 0 | -11,870 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 46,761 | 34,875 | -11,886 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 14,780 | 2,230 | -12,550 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 14,041 | 0 | -14,041 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,565,452 | 1,546,240 | -19,212 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 34,504 | 12,177 | -22,327 | 0.02 | 0.00 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 108,000 | 83,300 | -24,700 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 39,480 | 0 | -39,480 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 46,000 | 0 | -46,000 | 0.05 | 0.00 | -0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 102,108 | 0 | -102,108 | 0.03 | 0.00 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 106,636 | 0 | -106,636 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 322,090 | 196,939 | -125,151 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 305,000 | 155,000 | -150,000 | 0.03 | 0.02 | -0.02 | sell |
| Exome Asset Management LLC | 758,203 | 600,000 | -158,203 | 0.88 | 0.62 | -0.26 | sell |
| DIADEMA PARTNERS LP | 166,049 | 0 | -166,049 | 0.23 | 0.00 | -0.23 | sell |
| Persistent Asset Partners Ltd | 416,035 | 236,348 | -179,687 | 0.47 | 0.16 | -0.31 | sell |
| TD ASSET MANAGEMENT INC | 204,448 | 0 | -204,448 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 211,441 | 0 | -211,441 | 0.31 | 0.00 | -0.31 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,659 | 0 | -212,659 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 240,586 | 0 | -240,586 | 0.01 | 0.00 | -0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 367,103 | 0 | -367,103 | 0.46 | 0.00 | -0.46 | sell |
| Resolute Capital Asset Partners LLC | 400,000 | 0 | -400,000 | 0.45 | 0.00 | -0.45 | sell |
| Eversept Partners, LP | 5,391,548 | 4,987,499 | -404,049 | 0.71 | 0.58 | -0.14 | sell |
| Hudson Bay Capital Management LP | 656,460 | 89,386 | -567,074 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,382,500 | 1,454,400 | -928,100 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,577,856 | 0 | -1,577,856 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,701,411 | 0 | -1,701,411 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 2,293,578 | 0 | -2,293,578 | 0.35 | 0.00 | -0.35 | sell |
| PERCEPTIVE ADVISORS LLC | 12,050,000 | 8,928,149 | -3,121,851 | 0.52 | 0.31 | -0.21 | sell |