| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 13,063,687 | +13,063,687 | 0.00 | 0.94 | +0.94 | buy |
| BlackRock, Inc. | 1,876,340 | 10,436,760 | +8,560,420 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 411,772 | 5,253,403 | +4,841,631 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,546,240 | 3,760,485 | +2,214,245 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.08 | +0.08 | buy |
| STATE STREET CORP | 636,197 | 2,475,648 | +1,839,451 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 1,115,000 | 2,582,388 | +1,467,388 | 1.26 | 2.82 | +1.57 | buy |
| Aberdeen Group plc | 662,900 | 1,910,205 | +1,247,305 | 0.00 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,229,000 | +1,229,000 | 0.00 | 3.31 | +3.31 | buy |
| CITADEL ADVISORS LLC | 0 | 1,016,850 | +1,016,850 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 969,457 | +969,457 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 280,650 | 1,197,620 | +916,970 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,904,911 | 3,703,936 | +799,025 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,733,471 | 2,257,106 | +523,635 | 0.52 | 0.68 | +0.15 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,231,414 | 1,730,866 | +499,452 | 0.54 | 0.89 | +0.35 | buy |
| Ikarian Capital, LLC | 274,978 | 750,000 | +475,022 | 0.07 | 0.26 | +0.19 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 434,983 | +434,983 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 155,000 | 574,000 | +419,000 | 0.02 | 0.04 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 76,000 | 434,983 | +358,983 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 12,912 | 348,469 | +335,557 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 169,648 | 437,137 | +267,489 | 0.01 | 0.02 | +0.01 | buy |
| Virtu Financial LLC | 0 | 167,156 | +167,156 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 0 | 160,773 | +160,773 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 144,000 | +144,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 125,567 | +125,567 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 124,691 | +124,691 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 121,152 | +121,152 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 325,019 | 436,726 | +111,707 | 0.04 | 0.06 | +0.02 | buy |
| Simplify Asset Management Inc. | 350,000 | 450,543 | +100,543 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 27,640 | 126,602 | +98,962 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 87,875 | +87,875 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 77,398 | +77,398 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 67,890 | +67,890 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 67,674 | +67,674 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 64,715 | +64,715 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 58,385 | +58,385 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 52,040 | +52,040 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 43,530 | +43,530 | 0.00 | 0.00 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 0 | 41,100 | +41,100 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 40,132 | +40,132 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,230 | 36,253 | +34,023 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 33,100 | +33,100 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 31,153 | +31,153 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 29,228 | +29,228 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 28,900 | +28,900 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 28,143 | +28,143 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 27,450 | +27,450 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 22,265 | +22,265 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 11,500 | 32,227 | +20,727 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 19,325 | +19,325 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 18,847 | +18,847 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 14,323 | +14,323 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 14,066 | +14,066 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 13,395 | +13,395 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 12,504 | +12,504 | 0.00 | 0.00 | +0.00 | buy |
| NorthCrest Asset Manangement, LLC | 0 | 12,203 | +12,203 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 2,019,326 | 2,030,927 | +11,601 | 0.98 | 0.97 | -0.01 | buy |
| ExodusPoint Capital Management, LP | 13,125 | 24,561 | +11,436 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 10,506 | 15,506 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Total Clarity Wealth Management, Inc. | 27,000 | 31,795 | +4,795 | 0.01 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 381 | 4,741 | +4,360 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 3,643 | +3,643 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 16,454 | 19,757 | +3,303 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 17,000 | 20,250 | +3,250 | 0.00 | 0.01 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 2,538 | +2,538 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,033 | +2,033 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 498 | +498 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,333,000 | 2,333,000 | 0 | 0.09 | 0.09 | +0.00 | hold |
| FEDERATED HERMES, INC. | 3,136,607 | 3,136,607 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | 4,500,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 88,000 | 88,000 | 0 | 0.14 | 0.13 | -0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | 7,124,116 | 0 | 0.13 | 0.13 | -0.00 | hold |
| CHOREO, LLC | 15,743 | 15,743 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Octagon Capital Advisors LP | 10,276,317 | 10,276,317 | 0 | 1.99 | 1.97 | -0.02 | hold |
| Pale Fire Capital SE | 111,410 | 111,410 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Artia Global Partners LP | 1,992,367 | 1,992,367 | 0 | 0.79 | 0.79 | +0.01 | hold |
| Vestal Point Capital, LP | 2,500,000 | 2,500,000 | 0 | 0.12 | 0.12 | -0.00 | hold |
| Boxer Capital Management, LLC | 4,799,875 | 4,799,875 | 0 | 1.10 | 0.76 | -0.35 | hold |
| B Group, Inc. | 11,414,285 | 11,414,285 | 0 | 14.81 | 13.54 | -1.27 | hold |
| FRANKLIN RESOURCES INC | 5,785,189 | 5,785,189 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EntryPoint Capital, LLC | 79,495 | 78,498 | -997 | 0.04 | 0.04 | -0.00 | sell |
| FNY Investment Advisers, LLC | 9,951 | 8,500 | -1,451 | 0.01 | 0.01 | -0.00 | sell |
| RFG Advisory, LLC | 11,750 | 0 | -11,750 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 12,177 | 0 | -12,177 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 15,346 | 0 | -15,346 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 15,400 | 0 | -15,400 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,500 | 0 | -16,500 | 0.00 | 0.00 | -0.00 | sell |
| CTC Alternative Strategies, Ltd. | 17,441 | 0 | -17,441 | 0.07 | 0.00 | -0.07 | sell |
| GSA CAPITAL PARTNERS LLP | 43,730 | 25,896 | -17,834 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 87,704 | 68,536 | -19,168 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 31,400 | 0 | -31,400 | 0.01 | 0.00 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 33,146 | 0 | -33,146 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 34,875 | 0 | -34,875 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 53,842 | 12,081 | -41,761 | 0.00 | 0.00 | -0.00 | sell |