| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 12,050,000 | +12,050,000 | 0.00 | 0.52 | +0.52 | buy |
| Commodore Capital LP | 0 | 11,445,000 | +11,445,000 | 0.00 | 1.79 | +1.79 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 10,540,334 | +10,540,334 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 10,495,252 | +10,495,252 | 0.00 | 0.04 | +0.04 | buy |
| Octagon Capital Advisors LP | 0 | 9,567,898 | +9,567,898 | 0.00 | 2.81 | +2.81 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 7,124,116 | +7,124,116 | 0.00 | 0.17 | +0.17 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 6,911,237 | +6,911,237 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 5,391,548 | +5,391,548 | 0.00 | 0.71 | +0.71 | buy |
| FRANKLIN RESOURCES INC | 0 | 5,092,562 | +5,092,562 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 4,799,875 | +4,799,875 | 0.00 | 2.47 | +2.47 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 4,500,000 | +4,500,000 | 0.00 | 0.02 | +0.02 | buy |
| B Group, Inc. | 0 | 4,500,000 | +4,500,000 | 0.00 | 7.84 | +7.84 | buy |
| STEMPOINT CAPITAL LP | 0 | 4,192,375 | +4,192,375 | 0.00 | 1.69 | +1.69 | buy |
| MORGAN STANLEY | 0 | 4,142,446 | +4,142,446 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 2,382,500 | +2,382,500 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 0 | 2,293,578 | +2,293,578 | 0.00 | 0.35 | +0.35 | buy |
| VANGUARD GROUP INC | 0 | 2,115,622 | +2,115,622 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,004,845 | +2,004,845 | 0.00 | 0.35 | +0.35 | buy |
| Artia Global Partners LP | 0 | 1,992,367 | +1,992,367 | 0.00 | 0.75 | +0.75 | buy |
| BlackRock, Inc. | 0 | 1,879,319 | +1,879,319 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,871,420 | +1,871,420 | 0.00 | 0.09 | +0.09 | buy |
| CITADEL ADVISORS LLC | 0 | 1,701,411 | +1,701,411 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,577,856 | +1,577,856 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 26,620 | 1,565,452 | +1,538,832 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 1,300,031 | +1,300,031 | 0.00 | 0.79 | +0.79 | buy |
| Exome Asset Management LLC | 0 | 758,203 | +758,203 | 0.00 | 0.88 | +0.88 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 664,087 | +664,087 | 0.00 | 0.36 | +0.36 | buy |
| Hudson Bay Capital Management LP | 0 | 656,460 | +656,460 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 643,997 | +643,997 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 557,565 | +557,565 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 416,035 | +416,035 | 0.00 | 0.47 | +0.47 | buy |
| Resolute Capital Asset Partners LLC | 0 | 400,000 | +400,000 | 0.00 | 0.45 | +0.45 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 367,103 | +367,103 | 0.00 | 0.46 | +0.46 | buy |
| JANE STREET GROUP, LLC | 0 | 343,686 | +343,686 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 325,367 | +325,367 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 322,090 | +322,090 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 305,000 | +305,000 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 294,486 | +294,486 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 283,147 | +283,147 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 274,978 | +274,978 | 0.00 | 0.08 | +0.08 | buy |
| UBS Group AG | 0 | 247,754 | +247,754 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 240,586 | +240,586 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 212,659 | +212,659 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 211,441 | +211,441 | 0.00 | 0.31 | +0.31 | buy |
| TD ASSET MANAGEMENT INC | 0 | 204,448 | +204,448 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 184,100 | +184,100 | 0.00 | 0.09 | +0.09 | buy |
| DIADEMA PARTNERS LP | 0 | 166,049 | +166,049 | 0.00 | 0.23 | +0.23 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 132,648 | +132,648 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 108,000 | +108,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 106,636 | +106,636 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 102,108 | +102,108 | 0.00 | 0.03 | +0.03 | buy |
| Pale Fire Capital SE | 0 | 70,710 | +70,710 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 2,347 | 52,281 | +49,934 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 46,761 | +46,761 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 46,000 | +46,000 | 0.00 | 0.05 | +0.05 | buy |
| Lighthouse Investment Partners, LLC | 0 | 39,480 | +39,480 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 34,504 | +34,504 | 0.00 | 0.02 | +0.02 | buy |
| Total Clarity Wealth Management, Inc. | 0 | 29,935 | +29,935 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 27,640 | +27,640 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 16,650 | +16,650 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 16,072 | +16,072 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 14,891 | +14,891 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 14,780 | +14,780 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 14,041 | +14,041 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 12,912 | +12,912 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,870 | +11,870 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 11,231 | +11,231 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 10,512 | +10,512 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 9,951 | +9,951 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 14,085 | 21,669 | +7,584 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 13,000 | 15,000 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| Avion Wealth | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,396 | 1,025 | -4,371 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 29,406 | 0 | -29,406 | 0.00 | 0.00 | -0.00 | sell |