| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STEMPOINT CAPITAL LP | 0 | 168,442 | +168,442 | 0.00 | 0.18 | +0.18 | buy |
| TRUIST FINANCIAL CORP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 17,850 | +17,850 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 17,393 | +17,393 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 12,000 | 28,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 188,664 | 202,701 | +14,037 | 0.10 | 0.22 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 12,126 | +12,126 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 78,518 | 82,907 | +4,389 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 18,864 | 22,647 | +3,783 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 427,612 | 427,612 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 199,671 | 199,671 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Bank of New York Mellon Corp | 17,907 | 17,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA ADVISERS, LP | 27,018 | 27,018 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 2,692,594 | 2,692,594 | 0 | 1.34 | 2.35 | +1.01 | hold |
| Qube Research & Technologies Ltd | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Privium Fund Management (UK) Ltd | 119,730 | 119,730 | 0 | 0.15 | 0.25 | +0.09 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 6,314 | 6,314 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 2,194 | 2,000 | -194 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 18,127 | 17,591 | -536 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,338 | 2,580 | -1,758 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 30,900 | 26,600 | -4,300 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 64,000 | 59,000 | -5,000 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 25,145 | 19,748 | -5,397 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 11,506 | 0 | -11,506 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 15,831 | 0 | -15,831 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 113,300 | 84,600 | -28,700 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 38,035 | 0 | -38,035 | 0.00 | 0.00 | -0.00 | sell |