| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,271,832 | 3,788,176 | +1,516,344 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 332,394 | 1,190,579 | +858,185 | 0.44 | 1.62 | +1.18 | buy |
| BlackRock, Inc. | 116,037 | 630,459 | +514,422 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 149,408 | 636,674 | +487,266 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,359,509 | 1,602,852 | +243,343 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKET INC. | 0 | 235,610 | +235,610 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 371,453 | 568,421 | +196,968 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 179,593 | 346,697 | +167,104 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 194,397 | 288,717 | +94,320 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 91,455 | +91,455 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 1,579,000 | 1,667,800 | +88,800 | 7.19 | 7.31 | +0.11 | buy |
| Sio Capital Management, LLC | 1,437,500 | 1,514,300 | +76,800 | 2.14 | 1.95 | -0.18 | buy |
| OMERS ADMINISTRATION Corp | 0 | 75,100 | +75,100 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 1,680,000 | 1,744,042 | +64,042 | 0.04 | 0.03 | -0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 61,917 | +61,917 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 218,473 | 274,881 | +56,408 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 20,997 | 69,603 | +48,606 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 28,713 | 72,175 | +43,462 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 36,249 | +36,249 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 35,547 | 54,857 | +19,310 | 0.01 | 0.02 | +0.01 | buy |
| Jain Global LLC | 0 | 19,212 | +19,212 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 18,710 | +18,710 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 40,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 10,188 | +10,188 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,633 | 23,590 | +9,957 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 220,814 | 229,454 | +8,640 | 0.01 | 0.01 | -0.00 | buy |
| J. Goldman & Co LP | 141,748 | 146,341 | +4,593 | 0.03 | 0.02 | -0.00 | buy |
| Bank of New York Mellon Corp | 15,883 | 18,350 | +2,467 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 82,200 | 83,200 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 103 | 143 | +40 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 151,906 | 151,906 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 536,832 | 536,832 | 0 | 0.03 | 0.03 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,400,000 | 3,400,000 | 0 | 0.24 | 0.24 | +0.00 | hold |
| Semmax Financial Advisors Inc. | 1,572 | 1,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 1,400,000 | 1,400,000 | 0 | 0.65 | 0.66 | +0.01 | hold |
| 5AM Venture Management, LLC | 800,000 | 800,000 | 0 | 1.01 | 1.29 | +0.28 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 360,000 | 360,000 | 0 | 1.67 | 1.83 | +0.16 | hold |
| ADAR1 Capital Management, LLC | 122,690 | 122,690 | 0 | 0.13 | 0.10 | -0.03 | hold |
| Catalio Capital Management, LP | 1,088,691 | 1,088,691 | 0 | 1.26 | 1.15 | -0.11 | hold |
| ACORN CAPITAL ADVISORS, LLC | 1,279,800 | 1,279,800 | 0 | 3.64 | 3.64 | -0.00 | hold |
| BARCLAYS PLC | 93,239 | 93,239 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAILARD, INC. | 29,769 | 29,769 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRUIST FINANCIAL CORP | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| R Squared Ltd | 30 | 0 | -30 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,394 | 0 | -1,394 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 853,160 | 851,674 | -1,486 | 0.03 | 0.02 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 203,225 | 199,254 | -3,971 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 20,755 | 12,232 | -8,523 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,945 | 3,639 | -9,306 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 11,740 | 0 | -11,740 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 142,300 | 129,400 | -12,900 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 36,000 | 23,000 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 201,426 | 186,564 | -14,862 | 0.02 | 0.01 | -0.00 | sell |
| HBK INVESTMENTS L P | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 37,000 | 10,000 | -27,000 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 62,429 | 0 | -62,429 | 0.03 | 0.00 | -0.03 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 88,941 | 0 | -88,941 | 0.01 | 0.00 | -0.01 | sell |
| Opaleye Management Inc. | 1,825,000 | 1,730,000 | -95,000 | 1.69 | 1.64 | -0.05 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 517,152 | 272,342 | -244,810 | 0.02 | 0.01 | -0.01 | sell |
| Ikarian Capital, LLC | 350,489 | 0 | -350,489 | 0.53 | 0.00 | -0.53 | sell |
| CITADEL ADVISORS LLC | 1,027,534 | 412,531 | -615,003 | 0.01 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 2,088,937 | 0 | -2,088,937 | 0.02 | 0.00 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,250,000 | 0 | -2,250,000 | 0.02 | 0.00 | -0.02 | sell |