| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,900,000 | +1,900,000 | 0.00 | 0.05 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 168,442 | 984,113 | +815,671 | 0.18 | 0.60 | +0.42 | buy |
| CITADEL ADVISORS LLC | 0 | 665,372 | +665,372 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 520,000 | +520,000 | 0.00 | 0.03 | +0.03 | buy |
| Velan Capital Investment Management LP | 0 | 480,000 | +480,000 | 0.00 | 0.57 | +0.57 | buy |
| BAKER BROS. ADVISORS LP | 199,671 | 536,832 | +337,161 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,748 | 155,773 | +136,025 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 10,000 | 127,181 | +117,181 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 100,001 | +100,001 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 77,351 | +77,351 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 84,600 | 150,400 | +65,800 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 82,907 | 140,526 | +57,619 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 27,018 | 80,518 | +53,500 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 0 | 37,000 | +37,000 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 19,428 | +19,428 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 28,000 | 44,000 | +16,000 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 17,591 | 28,976 | +11,385 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,550 | +2,550 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,580 | 4,019 | +1,439 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 427,612 | 427,612 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 17,907 | 17,907 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRUIST FINANCIAL CORP | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 26,600 | 26,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 22,647 | 20,191 | -2,456 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management (UK) Ltd | 119,730 | 114,708 | -5,022 | 0.25 | 0.09 | -0.16 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 6,314 | 0 | -6,314 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 12,126 | 0 | -12,126 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 17,393 | 0 | -17,393 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 17,850 | 0 | -17,850 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 202,701 | 180,712 | -21,989 | 0.22 | 0.12 | -0.10 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59,000 | 24,200 | -34,800 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 2,692,594 | 2,304,262 | -388,332 | 2.35 | 1.21 | -1.14 | sell |