| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 100,001 | 851,567 | +751,566 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 427,612 | 759,612 | +332,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 150,400 | 336,740 | +186,340 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 480,000 | 574,000 | +94,000 | 0.57 | 1.14 | +0.57 | buy |
| TWO SIGMA ADVISERS, LP | 80,518 | 151,618 | +71,100 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 127,181 | 179,125 | +51,944 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 32,682 | +32,682 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 140,526 | 170,040 | +29,514 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 155,773 | 185,223 | +29,450 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 24,200 | 49,200 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 20,000 | 40,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 665,372 | 680,511 | +15,139 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 14,402 | +14,402 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 44,000 | 46,000 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Semmax Financial Advisors Inc. | 0 | 1,572 | +1,572 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 373 | +373 | 0.00 | 0.00 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 536,832 | 536,832 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MARSHALL WACE, LLP | 77,351 | 77,351 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,900,000 | 1,900,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Bank of New York Mellon Corp | 17,907 | 17,907 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 19,428 | 19,428 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 28,976 | 28,976 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 26,600 | 26,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,019 | 2,783 | -1,236 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,550 | 0 | -2,550 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,191 | 17,398 | -2,793 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKET INC. | 37,000 | 28,000 | -9,000 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 180,712 | 155,712 | -25,000 | 0.12 | 0.09 | -0.03 | sell |
| STEMPOINT CAPITAL LP | 984,113 | 942,857 | -41,256 | 0.60 | 0.52 | -0.08 | sell |
| Privium Fund Management (UK) Ltd | 114,708 | 0 | -114,708 | 0.09 | 0.00 | -0.09 | sell |
| ARMISTICE CAPITAL, LLC | 520,000 | 0 | -520,000 | 0.03 | 0.00 | -0.03 | sell |
| Opaleye Management Inc. | 2,304,262 | 1,681,154 | -623,108 | 1.21 | 0.51 | -0.70 | sell |