| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 60,100 | 113,300 | +53,200 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 38,035 | +38,035 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 10,000 | 12,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 427,612 | 427,612 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 64,000 | 64,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 78,518 | 78,518 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 199,671 | 199,671 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 17,907 | 17,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 15,831 | 15,831 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 18,864 | 18,864 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 2,692,594 | 2,692,594 | 0 | 1.46 | 1.34 | -0.12 | hold |
| Qube Research & Technologies Ltd | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 188,664 | 188,664 | 0 | 0.12 | 0.10 | -0.02 | hold |
| Privium Fund Management (UK) Ltd | 119,730 | 119,730 | 0 | 0.16 | 0.15 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 6,314 | 6,314 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 30,900 | 30,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,794 | 4,338 | -456 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 27,818 | 27,018 | -800 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 27,345 | 25,145 | -2,200 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 20,587 | 18,127 | -2,460 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 18,047 | 11,506 | -6,541 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 13,821 | 0 | -13,821 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 772,584 | 0 | -772,584 | 0.03 | 0.00 | -0.03 | sell |