| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 2,271,832 | +2,271,832 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,250,000 | +2,250,000 | 0.00 | 0.02 | +0.02 | buy |
| TORONTO DOMINION BANK | 0 | 2,088,937 | +2,088,937 | 0.00 | 0.02 | +0.02 | buy |
| Blackstone Inc. | 0 | 1,680,000 | +1,680,000 | 0.00 | 0.04 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,900,000 | 3,400,000 | +1,500,000 | 0.04 | 0.24 | +0.20 | buy |
| Sio Capital Management, LLC | 0 | 1,437,500 | +1,437,500 | 0.00 | 2.14 | +2.14 | buy |
| Integral Health Asset Management, LLC | 0 | 1,400,000 | +1,400,000 | 0.00 | 0.65 | +0.65 | buy |
| Velan Capital Investment Management LP | 574,000 | 1,579,000 | +1,005,000 | 1.14 | 7.19 | +6.05 | buy |
| 5AM Venture Management, LLC | 0 | 800,000 | +800,000 | 0.00 | 1.01 | +1.01 | buy |
| VANGUARD GROUP INC | 759,612 | 1,359,509 | +599,897 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 517,152 | +517,152 | 0.00 | 0.02 | +0.02 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 360,000 | +360,000 | 0.00 | 1.67 | +1.67 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,402 | 371,453 | +357,051 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 680,511 | 1,027,534 | +347,023 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 220,814 | +220,814 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 218,473 | +218,473 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 203,225 | +203,225 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 155,712 | 350,489 | +194,777 | 0.09 | 0.53 | +0.44 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 194,397 | +194,397 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 151,906 | +151,906 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 149,408 | +149,408 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,681,154 | 1,825,000 | +143,846 | 0.51 | 1.69 | +1.17 | buy |
| J. Goldman & Co LP | 0 | 141,748 | +141,748 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 0 | 122,690 | +122,690 | 0.00 | 0.13 | +0.13 | buy |
| BARCLAYS PLC | 0 | 93,239 | +93,239 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 17,398 | 88,941 | +71,543 | 0.00 | 0.01 | +0.01 | buy |
| 683 Capital Management, LLC | 0 | 62,429 | +62,429 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 26,600 | 82,200 | +55,600 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 35,547 | +35,547 | 0.00 | 0.01 | +0.01 | buy |
| BAILARD, INC. | 0 | 29,769 | +29,769 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 179,125 | 201,426 | +22,301 | 0.00 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 20,997 | +20,997 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,755 | +20,755 | 0.00 | 0.00 | +0.00 | buy |
| HBK INVESTMENTS L P | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 19,428 | 37,000 | +17,572 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 12,945 | +12,945 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 170,040 | 179,593 | +9,553 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 851,567 | 853,160 | +1,593 | 0.01 | 0.03 | +0.02 | buy |
| GROUP ONE TRADING LLC | 0 | 1,394 | +1,394 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 536,832 | 536,832 | 0 | 0.01 | 0.03 | +0.02 | hold |
| Semmax Financial Advisors Inc. | 1,572 | 1,572 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRUIST FINANCIAL CORP | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 28,976 | 28,713 | -263 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 373 | 0 | -373 | 0.00 | 0.00 | 0.00 | sell |
| BlackRock, Inc. | 116,977 | 116,037 | -940 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 17,907 | 15,883 | -2,024 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,783 | 0 | -2,783 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 46,000 | 36,000 | -10,000 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 32,682 | 11,740 | -20,942 | 0.00 | 0.01 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49,200 | 25,000 | -24,200 | 0.00 | 0.00 | +0.00 | sell |
| CIBC WORLD MARKET INC. | 28,000 | 0 | -28,000 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 77,351 | 0 | -77,351 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 151,618 | 0 | -151,618 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 185,223 | 13,633 | -171,590 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 336,740 | 142,300 | -194,440 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 942,857 | 332,394 | -610,463 | 0.52 | 0.44 | -0.08 | sell |