| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 3,990,000 | 3,990,000 | 0 | 29.92 | 23.43 | -6.49 | hold |
| BlackRock, Inc. | 2,302,531 | 2,538,376 | +235,845 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,866,875 | 1,872,100 | +5,225 | 0.00 | 0.00 | -0.00 | buy |
| Private Capital Management, LLC | 2,163,681 | 1,694,983 | -468,698 | 10.65 | 6.06 | -4.59 | sell |
| BRAIDWELL LP | 439,638 | 907,039 | +467,401 | 0.56 | 0.90 | +0.34 | buy |
| STATE STREET CORP | 730,973 | 827,698 | +96,725 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 722,730 | 721,108 | -1,622 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 622,818 | 664,714 | +41,896 | 0.04 | 0.02 | -0.01 | buy |
| STIFEL FINANCIAL CORP | 407,264 | 408,121 | +857 | 0.02 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 296,818 | 319,084 | +22,266 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 314,881 | 310,511 | -4,370 | 0.77 | 0.57 | -0.19 | sell |
| First Turn Management, LLC | 326,582 | 304,874 | -21,708 | 2.32 | 1.83 | -0.49 | sell |
| ROYCE & ASSOCIATES LP | 360,320 | 292,090 | -68,230 | 0.15 | 0.09 | -0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 293,770 | 277,670 | -16,100 | 0.02 | 0.01 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,629 | 255,218 | +3,589 | 0.00 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 209,515 | 205,844 | -3,671 | 0.11 | 0.07 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 152,992 | 204,047 | +51,055 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 365,922 | 202,220 | -163,702 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 87,941 | 200,529 | +112,588 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 215,731 | 188,592 | -27,139 | 0.04 | 0.02 | -0.01 | sell |
| UBS Group AG | 33,153 | 178,367 | +145,214 | 0.00 | 0.00 | +0.00 | buy |
| Westside Investment Management, Inc. | 165,944 | 163,541 | -2,403 | 1.59 | 1.16 | -0.43 | sell |
| TWO SIGMA INVESTMENTS, LP | 25,781 | 150,355 | +124,574 | 0.00 | 0.01 | +0.01 | buy |
| STANSBERRY ASSET MANAGEMENT, LLC | 61,113 | 136,744 | +75,631 | 0.34 | 0.60 | +0.25 | buy |
| Qube Research & Technologies Ltd | 0 | 135,115 | +135,115 | 0.00 | 0.01 | +0.01 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 167,460 | 125,520 | -41,940 | 0.61 | 0.32 | -0.29 | sell |
| Squarepoint Ops LLC | 14,724 | 124,636 | +109,912 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 142,001 | 118,602 | -23,399 | 0.01 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 130,424 | 111,894 | -18,530 | 0.03 | 0.02 | -0.01 | sell |
| Assenagon Asset Management S.A. | 190,655 | 111,584 | -79,071 | 0.02 | 0.01 | -0.01 | sell |
| Diametric Capital, LP | 74,026 | 110,295 | +36,269 | 1.65 | 2.50 | +0.85 | buy |
| DEUTSCHE BANK AG\ | 53,791 | 108,064 | +54,273 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,633 | 96,906 | -35,727 | 0.01 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 4,956 | 94,500 | +89,544 | 0.00 | 0.04 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 103,179 | 91,228 | -11,951 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 80,985 | 88,629 | +7,644 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 79,757 | 86,447 | +6,690 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 89,220 | 83,940 | -5,280 | 0.04 | 0.02 | -0.01 | sell |
| WOODMONT INVESTMENT COUNSEL LLC | 80,955 | 81,400 | +445 | 0.27 | 0.20 | -0.07 | buy |
| CAPTRUST FINANCIAL ADVISORS | 85,139 | 72,920 | -12,219 | 0.01 | 0.01 | -0.00 | sell |
| Birchview Capital, LP | 72,910 | 72,910 | 0 | 2.84 | 1.99 | -0.85 | hold |
| MILLENNIUM MANAGEMENT LLC | 168,933 | 67,262 | -101,671 | 0.01 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 104,263 | 63,395 | -40,868 | 0.10 | 0.05 | -0.06 | sell |
| BBR PARTNERS, LLC | 62,000 | 62,000 | 0 | 0.21 | 0.15 | -0.07 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 32,678 | 61,940 | +29,262 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 61,941 | 60,913 | -1,028 | 0.02 | 0.02 | -0.01 | sell |
| BARCLAYS PLC | 52,593 | 60,550 | +7,957 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 58,700 | 59,300 | +600 | 0.00 | 0.00 | -0.00 | buy |
| BARD ASSOCIATES INC | 58,700 | 57,500 | -1,200 | 0.90 | 0.66 | -0.24 | sell |
| Jump Financial, LLC | 54,100 | 50,260 | -3,840 | 0.05 | 0.04 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 126,646 | 47,392 | -79,254 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 4,496 | 46,899 | +42,403 | 0.01 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 238,367 | 46,877 | -191,490 | 0.00 | 0.00 | -0.00 | sell |
| EQUITABLE TRUST CO | 58,225 | 43,555 | -14,670 | 0.17 | 0.08 | -0.09 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 400 | 42,400 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,027 | 40,096 | -931 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 29,300 | 38,200 | +8,900 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 15,818 | 37,712 | +21,894 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 26,958 | 37,286 | +10,328 | 0.09 | 0.11 | +0.01 | buy |
| CITIGROUP INC | 25,502 | 34,585 | +9,083 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 31,900 | +31,900 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 31,447 | +31,447 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 11,874 | 30,689 | +18,815 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,020 | 29,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT LAKES ADVISORS, LLC | 0 | 28,963 | +28,963 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,491 | 28,230 | -261 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 27,403 | 27,368 | -35 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 26,938 | +26,938 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 25,962 | +25,962 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 12,817 | 25,579 | +12,762 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 15,679 | 25,206 | +9,527 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 24,624 | +24,624 | 0.00 | 0.03 | +0.03 | buy |
| Nicholas Investment Partners, LP | 69,477 | 23,822 | -45,655 | 0.29 | 0.07 | -0.22 | sell |
| Harvest Investment Services, LLC | 0 | 23,048 | +23,048 | 0.00 | 0.19 | +0.19 | buy |
| FineMark National Bank & Trust | 22,730 | 22,730 | 0 | 0.04 | 0.03 | -0.01 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 10,236 | 22,594 | +12,358 | 0.01 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 16,282 | 22,232 | +5,950 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 28,873 | 20,824 | -8,049 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,648 | 19,076 | +1,428 | 0.00 | 0.00 | -0.00 | buy |
| Mendota Financial Group, LLC | 19,073 | 19,073 | 0 | 0.41 | 0.41 | +0.01 | hold |
| MetLife Investment Management, LLC | 17,882 | 18,908 | +1,026 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 18,688 | +18,688 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,771 | 17,356 | +585 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 43,109 | 16,918 | -26,191 | 0.01 | 0.00 | -0.01 | sell |
| Sonora Investment Management Group, LLC | 0 | 15,448 | +15,448 | 0.00 | 0.04 | +0.04 | buy |
| Corebridge Financial, Inc. | 16,332 | 15,186 | -1,146 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 199,024 | 14,919 | -184,105 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 17,422 | 14,271 | -3,151 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,027 | 13,901 | -8,126 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 13,500 | 13,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dynamic Technology Lab Private Ltd | 0 | 12,550 | +12,550 | 0.00 | 0.07 | +0.07 | buy |
| AVANTAX ADVISORY SERVICES, INC. | 11,261 | 12,534 | +1,273 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 11,034 | 11,977 | +943 | 0.00 | 0.00 | -0.00 | buy |
| Calamos Advisors LLC | 8,810 | 11,913 | +3,103 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 18,803 | 11,841 | -6,962 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 11,671 | +11,671 | 0.00 | 0.01 | +0.01 | buy |
| Lido Advisors, LLC | 11,338 | 11,140 | -198 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,552 | 11,080 | -472 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 7,868 | 10,289 | +2,421 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 8,900 | 10,127 | +1,227 | 0.00 | 0.00 | -0.00 | buy |