| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,888,901 | 9,130,817 | +241,916 | 2.76 | 2.53 | -0.23 | buy |
| STATE STREET CORP | 6,787,332 | 8,152,902 | +1,365,570 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 7,120,417 | 7,980,661 | +860,244 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,601,797 | 2,737,657 | +135,860 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,138,594 | 2,726,388 | +1,587,794 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,200,225 | 2,508,152 | +307,927 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 1,743,074 | 2,084,013 | +340,939 | 0.27 | 0.30 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,597,427 | 1,888,427 | +291,000 | 0.04 | 0.05 | +0.01 | buy |
| MORGAN STANLEY | 1,961,539 | 1,798,856 | -162,683 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 1,683,951 | +1,683,951 | 0.00 | 0.04 | +0.04 | buy |
| Boston Partners | 1,541,660 | 1,506,930 | -34,730 | 0.03 | 0.03 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,418,741 | 1,429,748 | +11,007 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,286,492 | 1,255,880 | -30,612 | 0.11 | 0.09 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,196,558 | 1,219,418 | +22,860 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 510,104 | 1,118,440 | +608,336 | 0.01 | 0.02 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 629,372 | 1,083,037 | +453,665 | 0.04 | 0.06 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 956,333 | 1,075,559 | +119,226 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 527,902 | 1,061,704 | +533,802 | 0.19 | 0.35 | +0.15 | buy |
| Opaleye Management Inc. | 1,257,200 | 1,004,355 | -252,845 | 5.70 | 3.49 | -2.21 | sell |
| GOLDMAN SACHS GROUP INC | 958,413 | 1,001,281 | +42,868 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 919,647 | 994,058 | +74,411 | 0.00 | 0.00 | -0.00 | buy |
| LSV ASSET MANAGEMENT | 1,230,700 | 896,000 | -334,700 | 0.05 | 0.03 | -0.02 | sell |
| Bank of New York Mellon Corp | 789,621 | 817,455 | +27,834 | 0.00 | 0.00 | -0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 843,931 | 809,360 | -34,571 | 0.14 | 0.12 | -0.02 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 578,307 | 649,440 | +71,133 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 619,086 | 626,253 | +7,167 | 0.01 | 0.00 | -0.00 | buy |
| Man Group plc | 644,216 | 619,411 | -24,805 | 0.03 | 0.03 | -0.00 | sell |
| Ikarian Capital, LLC | 505,862 | 518,386 | +12,524 | 2.33 | 2.25 | -0.08 | buy |
| Woodline Partners LP | 0 | 503,758 | +503,758 | 0.00 | 0.07 | +0.07 | buy |
| Altium Capital Management LLC | 385,000 | 500,000 | +115,000 | 4.46 | 3.56 | -0.90 | buy |
| CITIGROUP INC | 205,844 | 490,704 | +284,860 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 352,162 | 486,774 | +134,612 | 0.02 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 436,608 | 476,420 | +39,812 | 0.00 | 0.00 | -0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 348,600 | 458,400 | +109,800 | 0.55 | 0.53 | -0.02 | buy |
| GABLES CAPITAL MANAGEMENT INC. | 434,260 | 436,660 | +2,400 | 4.54 | 3.83 | -0.70 | buy |
| Point72 Asset Management, L.P. | 496,591 | 417,926 | -78,665 | 0.03 | 0.02 | -0.01 | sell |
| JW Asset Management, LLC | 413,392 | 413,392 | 0 | 3.97 | 2.41 | -1.56 | hold |
| BANK OF AMERICA CORP /DE/ | 749,008 | 408,206 | -340,802 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 469,316 | 389,099 | -80,217 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 452,235 | 381,350 | -70,885 | 0.00 | 0.00 | -0.00 | sell |
| Brandywine Global Investment Management, LLC | 178,530 | 371,383 | +192,853 | 0.02 | 0.04 | +0.02 | buy |
| RHUMBLINE ADVISERS | 288,921 | 312,964 | +24,043 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 287,815 | 309,491 | +21,676 | 0.00 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 307,912 | 300,951 | -6,961 | 0.93 | 0.82 | -0.12 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 288,000 | +288,000 | 0.00 | 0.74 | +0.74 | buy |
| Hudson Bay Capital Management LP | 160,000 | 280,000 | +120,000 | 0.02 | 0.04 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 257,723 | 278,790 | +21,067 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 917,578 | 265,135 | -652,443 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 342,801 | 261,065 | -81,736 | 0.01 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 251,219 | 257,535 | +6,316 | 0.05 | 0.05 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 45,258 | 242,490 | +197,232 | 0.01 | 0.04 | +0.03 | buy |
| Russell Investments Group, Ltd. | 191,881 | 237,744 | +45,863 | 0.01 | 0.01 | +0.00 | buy |
| CLARK ESTATES INC/NY | 197,500 | 231,000 | +33,500 | 0.56 | 0.61 | +0.04 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 207,964 | 229,864 | +21,900 | 0.03 | 0.03 | -0.00 | buy |
| GLOBEFLEX CAPITAL L P | 228,784 | 228,784 | 0 | 0.39 | 0.36 | -0.04 | hold |
| PRUDENTIAL FINANCIAL INC | 218,330 | 227,689 | +9,359 | 0.01 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 185,923 | 226,056 | +40,133 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 200,500 | 225,075 | +24,575 | 0.07 | 0.07 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 99,845 | 224,083 | +124,238 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 153,031 | 210,402 | +57,371 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 189,100 | 208,800 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 188,360 | +188,360 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 125,450 | 187,852 | +62,402 | 0.81 | 1.06 | +0.25 | buy |
| BRIDGER MANAGEMENT, LLC | 184,527 | 184,527 | 0 | 1.19 | 1.33 | +0.14 | hold |
| Paradiem, LLC | 198,219 | 181,295 | -16,924 | 0.93 | 0.71 | -0.21 | sell |
| DekaBank Deutsche Girozentrale | 0 | 171,376 | +171,376 | 0.00 | 0.01 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 130,646 | 147,245 | +16,599 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 146,955 | +146,955 | 0.00 | 0.06 | +0.06 | buy |
| Allspring Global Investments Holdings, LLC | 155,234 | 143,481 | -11,753 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 303,085 | 140,801 | -162,284 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 147,844 | 139,993 | -7,851 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 182,543 | 129,101 | -53,442 | 0.01 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 108,326 | 120,850 | +12,524 | 0.06 | 0.05 | -0.01 | buy |
| NORGES BANK | 0 | 120,000 | +120,000 | 0.00 | 0.00 | +0.00 | buy |
| Cyndeo Wealth Partners, LLC | 100,000 | 118,444 | +18,444 | 0.16 | 0.16 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 117,152 | 117,152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,489 | 115,744 | +255 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 111,664 | 112,619 | +955 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102,011 | 106,357 | +4,346 | 0.00 | 0.00 | -0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 157,500 | 105,000 | -52,500 | 0.60 | 0.39 | -0.21 | sell |
| ALPS ADVISORS INC | 72,431 | 104,715 | +32,284 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 178,721 | 104,536 | -74,185 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 59,134 | 97,980 | +38,846 | 0.00 | 0.00 | +0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 86,571 | 97,747 | +11,176 | 0.01 | 0.01 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 89,299 | 96,890 | +7,591 | 0.00 | 0.00 | -0.00 | buy |
| JUNCTURE WEALTH STRATEGIES, LLC | 10,947 | 94,583 | +83,636 | 0.08 | 0.65 | +0.57 | buy |
| Qube Research & Technologies Ltd | 0 | 90,250 | +90,250 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 298,899 | 89,967 | -208,932 | 0.01 | 0.00 | -0.01 | sell |
| CAMPBELL NEWMAN ASSET MANAGEMENT INC | 0 | 89,472 | +89,472 | 0.00 | 0.12 | +0.12 | buy |
| Summit Global Investments | 90,512 | 86,702 | -3,810 | 0.10 | 0.10 | +0.00 | sell |
| SEI INVESTMENTS CO | 50,739 | 83,360 | +32,621 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 45,951 | 81,017 | +35,066 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 61,564 | 80,142 | +18,578 | 0.04 | 0.05 | +0.01 | buy |
| Trexquant Investment LP | 0 | 78,750 | +78,750 | 0.00 | 0.03 | +0.03 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 77,128 | 76,958 | -170 | 0.00 | 0.00 | -0.00 | sell |
| Livforsakringsbolaget Skandia, Omsesidigt | 74,900 | 74,900 | 0 | 0.12 | 0.10 | -0.02 | hold |
| FMR LLC | 12,924 | 73,830 | +60,906 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 64,678 | 68,675 | +3,997 | 0.00 | 0.00 | -0.00 | buy |
| State of Alaska, Department of Revenue | 61,652 | 68,038 | +6,386 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 89,740 | 65,880 | -23,860 | 0.00 | 0.00 | -0.00 | sell |