| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ally Bridge Group (NY) LLC | 414,219 | 620,319 | +206,100 | 5.23 | 10.52 | +5.29 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 185,700 | +185,700 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 55,000 | 205,000 | +150,000 | 0.10 | 0.44 | +0.34 | buy |
| Woodline Partners LP | 395,295 | 441,911 | +46,616 | 0.02 | 0.02 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 16,043 | 62,078 | +46,035 | 0.00 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 139,275 | 164,275 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 11,371 | +11,371 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 92,850 | 95,000 | +2,150 | 0.11 | 0.11 | +0.01 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 325,591 | 325,591 | 0 | 0.71 | 0.61 | -0.10 | hold |
| Yu Fan | 329,760 | 329,760 | 0 | 4.32 | 4.02 | -0.30 | hold |
| Deep Track Capital, LP | 835,655 | 835,655 | 0 | 0.22 | 0.16 | -0.06 | hold |
| TD Waterhouse Canada Inc. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 696,378 | 696,378 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 94 | -6 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 95,350 | 92,850 | -2,500 | 0.07 | 0.06 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 77,921 | 56,045 | -21,876 | 0.00 | 0.00 | -0.00 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 50,660 | 0 | -50,660 | 0.18 | 0.00 | -0.18 | sell |
| GREAT POINT PARTNERS LLC | 371,402 | 86,150 | -285,252 | 1.16 | 0.27 | -0.89 | sell |