| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 16,941,357 | 21,231,974 | +4,290,617 | 1.42 | 2.80 | +1.38 | buy |
| JANUS HENDERSON GROUP PLC | 2,641,065 | 4,020,965 | +1,379,900 | 0.01 | 0.02 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 86,561 | 987,933 | +901,372 | 0.00 | 0.04 | +0.04 | buy |
| Blue Owl Capital Holdings LP | 3,414,468 | 3,994,468 | +580,000 | 3.71 | 6.06 | +2.34 | buy |
| Woodline Partners LP | 796,226 | 1,150,333 | +354,107 | 0.04 | 0.08 | +0.04 | buy |
| DAFNA Capital Management LLC | 323,873 | 656,373 | +332,500 | 0.35 | 1.13 | +0.78 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,276,680 | 1,433,453 | +156,773 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 319,901 | 202,783 | +117,118 | 0.11 | 0.11 | 0.00 | sell |
| MANGROVE PARTNERS IM, LLC | 805,815 | 855,815 | +50,000 | 0.25 | 0.45 | +0.20 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,500 | 84,500 | +35,000 | 0.01 | 0.01 | 0.00 | sell |
| J. Goldman & Co LP | 56,042 | 28,000 | -28,042 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 783,172 | 740,877 | -42,295 | 0.96 | 1.50 | +0.54 | sell |
| Atlas Venture Advisors, Inc. | 292,184 | 232,184 | -60,000 | 0.23 | 0.35 | +0.12 | sell |
| Ikarian Capital, LLC | 602,868 | 438,528 | -164,340 | 0.75 | 0.91 | +0.15 | sell |
| Opaleye Management Inc. | 623,500 | 174,413 | -449,087 | 0.75 | 0.29 | -0.47 | sell |