| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 6,045,351 | +6,045,351 | 0.00 | 0.58 | +0.58 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 16,941,357 | 21,231,974 | +4,290,617 | 1.42 | 2.80 | +1.38 | buy |
| GOLDMAN SACHS GROUP INC | 133,867 | 3,417,598 | +3,283,731 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,641,065 | 4,020,965 | +1,379,900 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,088,227 | +1,088,227 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 1,455,243 | 2,367,701 | +912,458 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 86,561 | 987,933 | +901,372 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 782,270 | +782,270 | 0.00 | 0.01 | +0.01 | buy |
| Altium Capital Management LLC | 0 | 695,000 | +695,000 | 0.00 | 2.36 | +2.36 | buy |
| RTW INVESTMENTS, LP | 0 | 650,000 | +650,000 | 0.00 | 0.07 | +0.07 | buy |
| Assenagon Asset Management S.A. | 0 | 636,185 | +636,185 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 3,414,468 | 3,994,468 | +580,000 | 3.71 | 6.06 | +2.34 | buy |
| Alyeska Investment Group, L.P. | 0 | 550,027 | +550,027 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 682,359 | 1,164,259 | +481,900 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 796,226 | 1,150,333 | +354,107 | 0.04 | 0.08 | +0.04 | buy |
| DAFNA Capital Management LLC | 323,873 | 656,373 | +332,500 | 0.35 | 1.13 | +0.78 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 247,042 | 503,442 | +256,400 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 647,718 | 869,383 | +221,665 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 34,029 | 210,472 | +176,443 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 465,117 | 630,680 | +165,563 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,276,680 | 1,433,453 | +156,773 | 0.01 | 0.02 | +0.01 | buy |
| Caption Management, LLC | 0 | 142,900 | +142,900 | 0.00 | 0.12 | +0.12 | buy |
| Concentric Capital Strategies, LP | 0 | 123,325 | +123,325 | 0.00 | 0.06 | +0.06 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,473 | 131,712 | +120,239 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 99,788 | +99,788 | 0.00 | 0.00 | +0.00 | buy |
| HAP Trading, LLC | 0 | 98,984 | +98,984 | 0.00 | 0.23 | +0.23 | buy |
| Qube Research & Technologies Ltd | 0 | 89,094 | +89,094 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 109,324 | 193,424 | +84,100 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 80,900 | +80,900 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 78,205 | +78,205 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 0 | 60,900 | +60,900 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 60,502 | 118,887 | +58,385 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 58,190 | +58,190 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 58,122 | +58,122 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 58,116 | +58,116 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 805,815 | 855,815 | +50,000 | 0.25 | 0.45 | +0.21 | buy |
| Semanteon Capital Management, LP | 0 | 48,272 | +48,272 | 0.00 | 0.23 | +0.23 | buy |
| Trexquant Investment LP | 0 | 46,194 | +46,194 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 39,723 | +39,723 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 38,825 | +38,825 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,516 | 45,636 | +34,120 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 268,292 | 295,422 | +27,130 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 27,117 | +27,117 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 22,087 | +22,087 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 21,142 | +21,142 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 18,600 | +18,600 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 17,578 | +17,578 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 16,906 | +16,906 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 0 | 13,927 | +13,927 | 0.00 | 0.09 | +0.09 | buy |
| MetLife Investment Management, LLC | 0 | 13,923 | +13,923 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,780 | +12,780 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 10,273 | +10,273 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 73,763 | 83,009 | +9,246 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 8,638 | +8,638 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 25,232 | 29,062 | +3,830 | 0.01 | 0.02 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 2,420 | 6,173 | +3,753 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 28,322 | 31,461 | +3,139 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 5,300 | 7,900 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,995 | 9,428 | +1,433 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 1,410 | +1,410 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,664 | 4,884 | +1,220 | 0.00 | 0.00 | +0.00 | buy |
| Aspect Partners, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.01 | +0.01 | buy |
| Quarry LP | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 415 | +415 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 576 | 716 | +140 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 12,748 | 12,825 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,118 | 2,118 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BFSG, LLC | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Solstein Capital, LLC | 4,477 | 4,477 | 0 | 0.02 | 0.02 | +0.01 | hold |
| Fi3 FINANCIAL ADVISORS, LLC | 25,448 | 25,448 | 0 | 0.06 | 0.09 | +0.04 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 35,260 | 35,260 | 0 | 0.01 | 0.01 | +0.00 | hold |
| US BANCORP \DE\ | 1,175 | 1,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,607 | 6,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tennessee Valley Asset Management Partners | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,481 | 2,105 | -376 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 12,258 | 11,816 | -442 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 272,373 | 271,924 | -449 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 2,237 | 865 | -1,372 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 28,039 | 26,598 | -1,441 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,221 | 2,617 | -1,604 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 96,764 | 85,775 | -10,989 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 450,400 | 438,400 | -12,000 | 0.01 | 0.01 | +0.00 | sell |
| Pale Fire Capital SE | 12,040 | 0 | -12,040 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 14,159 | 0 | -14,159 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 35,291 | 18,204 | -17,087 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 58,550 | 41,049 | -17,501 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 195,188 | 175,744 | -19,444 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 22,692 | 0 | -22,692 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 129,958 | 102,894 | -27,064 | 0.02 | 0.02 | +0.00 | sell |
| J. Goldman & Co LP | 56,042 | 28,000 | -28,042 | 0.01 | 0.01 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 119,500 | 84,500 | -35,000 | 0.01 | 0.01 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 783,172 | 740,877 | -42,295 | 0.96 | 1.50 | +0.54 | sell |
| Atlas Venture Advisors, Inc. | 292,184 | 232,184 | -60,000 | 0.23 | 0.35 | +0.12 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 319,901 | 202,783 | -117,118 | 0.05 | 0.04 | -0.00 | sell |
| Ikarian Capital, LLC | 602,868 | 438,528 | -164,340 | 0.75 | 0.91 | +0.15 | sell |
| Opaleye Management Inc. | 623,500 | 174,413 | -449,087 | 0.75 | 0.29 | -0.47 | sell |
| Verition Fund Management LLC | 2,811,131 | 1,501,619 | -1,309,512 | 0.13 | 0.11 | -0.02 | sell |