| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 1,914,077 | +1,914,077 | 0.00 | 0.92 | +0.92 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 513,542 | 974,971 | +461,429 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 984,077 | 1,442,473 | +458,396 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 434,286 | +434,286 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 254,947 | 673,012 | +418,065 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 67,024 | 394,024 | +327,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 85,788 | 394,745 | +308,957 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 4,653,040 | 4,778,040 | +125,000 | 4.15 | 3.31 | -0.84 | buy |
| Cubist Systematic Strategies, LLC | 233,873 | 354,232 | +120,359 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 112,226 | +112,226 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 103,216 | +103,216 | 0.00 | 0.01 | +0.01 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 47,100 | 146,284 | +99,184 | 0.17 | 0.27 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,579 | 161,902 | +94,323 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 53,239 | +53,239 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,452 | 64,617 | +40,165 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 31,880 | +31,880 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,958 | 87,527 | +29,569 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 26,869 | +26,869 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,192,925 | 2,217,808 | +24,883 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 886,414 | 907,961 | +21,547 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,993 | 33,922 | +19,929 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 17,166 | +17,166 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 16,460 | +16,460 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 12,190 | 23,280 | +11,090 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 10,704 | +10,704 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,242 | +10,242 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 18,000 | 28,000 | +10,000 | 0.06 | 0.06 | +0.00 | buy |
| RHUMBLINE ADVISERS | 56,200 | 65,018 | +8,818 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 56,294 | 64,284 | +7,990 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 32,309 | 37,518 | +5,209 | 0.03 | 0.01 | -0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3,756 | +3,756 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,657 | 22,494 | +2,837 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,850 | 4,801 | +1,951 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,117 | 25,209 | +1,092 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,452 | 16,310 | +858 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 865 | 1,452 | +587 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,703 | 16,216 | +513 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 310 | +310 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 264 | +264 | 0.00 | 0.00 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,340 | 1,583 | +243 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 198 | +198 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 193 | +193 | 0.00 | 0.00 | +0.00 | buy |
| Fi3 FINANCIAL ADVISORS, LLC | 23,798 | 23,970 | +172 | 0.03 | 0.02 | -0.01 | buy |
| SBI Securities Co., Ltd. | 118 | 191 | +73 | 0.00 | 0.00 | -0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 35,270 | 35,316 | +46 | 0.01 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 21,231,974 | 21,231,974 | 0 | 1.56 | 0.90 | -0.66 | hold |
| Ameritas Investment Partners, Inc. | 4,121 | 4,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,048 | 3,048 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 33,060 | 33,060 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 43 | 43 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,045,351 | 6,045,351 | 0 | 0.31 | 0.22 | -0.09 | hold |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 371,434 | 371,434 | 0 | 0.37 | 0.23 | -0.14 | hold |
| Bank of New York Mellon Corp | 100,453 | 100,453 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANGROVE PARTNERS IM, LLC | 770,233 | 770,233 | 0 | 0.33 | 0.18 | -0.15 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 13,731 | 13,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Solstein Capital, LLC | 4,477 | 4,477 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ikarian Capital, LLC | 58,526 | 58,526 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Woodline Partners LP | 622,682 | 622,682 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Police & Firemen's Retirement System of New Jersey | 9,082 | 9,082 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 10,573 | 10,573 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 9,718 | 9,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,619 | 6,619 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 7,900 | 7,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,126 | 2,085 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Larson Financial Group LLC | 120 | 0 | -120 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 16,260 | 16,112 | -148 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,915 | 20,609 | -306 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 405 | 0 | -405 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,733 | 12,092 | -641 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 720 | 0 | -720 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,529 | 12,799 | -730 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 219,987 | 218,434 | -1,553 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 35,675 | 33,914 | -1,761 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,465 | 3,918 | -2,547 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 14,870 | 11,985 | -2,885 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 3,800 | 0 | -3,800 | 0.02 | 0.00 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 44,052 | 40,037 | -4,015 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 51,590 | 47,460 | -4,130 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 19,391 | 14,974 | -4,417 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 6,886 | 127 | -6,759 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 81,150 | 72,649 | -8,501 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 188,543 | 180,027 | -8,516 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 842,891 | 832,541 | -10,350 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 376,458 | 365,668 | -10,790 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 11,270 | 0 | -11,270 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 11,635 | 0 | -11,635 | 0.02 | 0.00 | -0.02 | sell |
| GROUP ONE TRADING LLC | 13,353 | 1,125 | -12,228 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 14,078 | 0 | -14,078 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 31,787 | 16,729 | -15,058 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 70,425 | 54,259 | -16,166 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 18,160 | 0 | -18,160 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 18,428 | 0 | -18,428 | 0.00 | 0.00 | -0.00 | sell |