| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 21,231,974 | 21,231,974 | 0 | 0.90 | 1.11 | +0.21 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,045,351 | 6,045,351 | 0 | 0.22 | 0.29 | +0.08 | hold |
| Blue Owl Capital Holdings LP | 4,778,040 | 4,928,040 | +150,000 | 3.31 | 4.60 | +1.28 | buy |
| Opaleye Management Inc. | 1,914,077 | 4,110,000 | +2,195,923 | 0.92 | 2.40 | +1.49 | buy |
| MILLENNIUM MANAGEMENT LLC | 673,012 | 3,655,189 | +2,982,177 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 3,123,988 | 3,039,980 | -84,008 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 2,217,808 | 2,142,031 | -75,777 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 1,442,473 | 2,075,882 | +633,409 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 434,286 | 1,336,255 | +901,969 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 394,024 | 1,146,924 | +752,900 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 907,961 | 904,425 | -3,536 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 394,745 | 903,611 | +508,866 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 832,541 | 858,968 | +26,427 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 770,233 | 770,233 | 0 | 0.18 | 0.24 | +0.06 | hold |
| Caption Management, LLC | 0 | 689,290 | +689,290 | 0.00 | 0.18 | +0.18 | buy |
| Woodline Partners LP | 622,682 | 622,682 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Verition Fund Management LLC | 567,683 | 567,683 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 974,971 | 561,742 | -413,229 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 355,995 | 535,464 | +179,469 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 112,226 | 428,488 | +316,262 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 371,434 | 371,434 | 0 | 0.23 | 0.30 | +0.07 | hold |
| NORTHERN TRUST CORP | 365,668 | 343,981 | -21,687 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 180,027 | 307,198 | +127,171 | 0.01 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 218,434 | 256,861 | +38,427 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,902 | 250,295 | +88,393 | 0.00 | 0.00 | +0.00 | buy |
| HAP Trading, LLC | 0 | 237,776 | +237,776 | 0.00 | 0.30 | +0.30 | buy |
| ADAR1 Capital Management, LLC | 0 | 237,605 | +237,605 | 0.00 | 0.11 | +0.11 | buy |
| Hudson Bay Capital Management LP | 0 | 228,761 | +228,761 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 174,788 | 227,002 | +52,214 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 220,201 | +220,201 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 366,304 | 196,635 | -169,669 | 0.19 | 0.15 | -0.05 | sell |
| XTX Topco Ltd | 0 | 167,404 | +167,404 | 0.00 | 0.02 | +0.02 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 146,284 | 146,284 | 0 | 0.27 | 0.34 | +0.07 | hold |
| SIMPLEX TRADING, LLC | 264 | 140,424 | +140,160 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 2,671,271 | 131,622 | -2,539,649 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,457 | 111,400 | +10,943 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 103,216 | 103,216 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ROYAL BANK OF CANADA | 0 | 100,897 | +100,897 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 99,922 | +99,922 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 100,453 | 99,889 | -564 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 54,259 | 84,860 | +30,601 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 69,799 | +69,799 | 0.00 | 0.06 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 64,284 | 69,285 | +5,001 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 65,018 | 67,358 | +2,340 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 33,060 | 62,380 | +29,320 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 0 | 61,723 | +61,723 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 16,460 | 57,261 | +40,801 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 64,617 | 55,648 | -8,969 | 0.00 | 0.00 | +0.00 | sell |
| Massar Capital Management, LP | 0 | 51,556 | +51,556 | 0.00 | 0.11 | +0.11 | buy |
| GROUP ONE TRADING LLC | 1,125 | 48,225 | +47,100 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 46,760 | +46,760 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 33,914 | 41,900 | +7,986 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 40,037 | 39,031 | -1,006 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 37,518 | 37,518 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 35,316 | 35,695 | +379 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 28,000 | 33,000 | +5,000 | 0.06 | 0.10 | +0.03 | buy |
| CWM, LLC | 10,704 | 32,652 | +21,948 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 87,527 | 31,515 | -56,012 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 72,649 | 31,354 | -41,295 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 22,494 | 29,559 | +7,065 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 23,280 | 29,030 | +5,750 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 26,359 | +26,359 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 33,922 | 25,963 | -7,959 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fi3 FINANCIAL ADVISORS, LLC | 23,970 | 24,172 | +202 | 0.02 | 0.03 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,209 | 24,117 | -1,092 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,310 | 21,301 | +4,991 | 0.00 | 0.00 | +0.00 | buy |
| Next Level Private LLC | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| AXQ CAPITAL, LP | 0 | 19,853 | +19,853 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,216 | 16,165 | -51 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 16,112 | 15,204 | -908 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,312 | 13,830 | +12,518 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 13,629 | +13,629 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 13,444 | +13,444 | 0.00 | 0.00 | +0.00 | buy |
| Keystone Financial Group | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,799 | 12,860 | +61 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,092 | 12,092 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 11,985 | 11,070 | -915 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,867 | +10,867 | 0.00 | 0.00 | +0.00 | buy |
| Cherry Tree Wealth Management, LLC | 0 | 10,618 | +10,618 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 10,573 | 10,573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OPPENHEIMER & CO INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,082 | 9,082 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 7,900 | 7,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,619 | 6,619 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,801 | 5,839 | +1,038 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,918 | 5,770 | +1,852 | 0.00 | 0.00 | +0.00 | buy |
| Solstein Capital, LLC | 4,477 | 4,477 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,121 | 4,121 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 0 | 4,121 | +4,121 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,718 | 3,631 | -6,087 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 2,655 | +2,655 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 1,500 | 2,654 | +1,154 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,085 | 2,473 | +388 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,756 | 1,638 | -2,118 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,583 | 1,583 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,452 | 1,452 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 1,175 | 1,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 43 | 1,143 | +1,100 | 0.00 | 0.00 | +0.00 | buy |