| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 21,231,974 | 30,606,974 | +9,375,000 | 1.11 | 1.52 | +0.40 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,045,351 | 6,045,351 | 0 | 0.29 | 0.24 | -0.05 | hold |
| Blue Owl Capital Holdings LP | 4,928,040 | 5,853,040 | +925,000 | 4.60 | 5.87 | +1.27 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,655,189 | 4,896,831 | +1,241,642 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 4,110,000 | 3,720,867 | -389,133 | 2.40 | 1.49 | -0.91 | sell |
| BlackRock, Inc. | 3,039,980 | 3,339,192 | +299,212 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 3,125,000 | +3,125,000 | 0.00 | 0.12 | +0.12 | buy |
| VANGUARD GROUP INC | 2,142,031 | 3,087,840 | +945,809 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,900,000 | +1,900,000 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 2,075,882 | 1,887,169 | -188,713 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 622,682 | 1,622,850 | +1,000,168 | 0.01 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 131,622 | 1,575,001 | +1,443,379 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,336,255 | 1,477,506 | +141,251 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 689,290 | 1,312,352 | +623,062 | 0.18 | 0.25 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 1,223,866 | +1,223,866 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 371,434 | 1,027,764 | +656,330 | 0.30 | 0.82 | +0.52 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 904,425 | 1,022,527 | +118,102 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 1.13 | +1.13 | buy |
| STATE STREET CORP | 858,968 | 891,869 | +32,901 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 561,742 | 858,642 | +296,900 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 567,683 | 567,683 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 428,488 | 562,403 | +133,915 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 535,464 | 535,464 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANGROVE PARTNERS IM, LLC | 770,233 | 442,236 | -327,997 | 0.24 | 0.11 | -0.13 | sell |
| JANE STREET GROUP, LLC | 0 | 422,712 | +422,712 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 228,761 | 403,449 | +174,688 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 343,981 | 378,307 | +34,326 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 286,533 | +286,533 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 196,635 | 260,385 | +63,750 | 0.15 | 0.20 | +0.05 | buy |
| UBS Group AG | 0 | 257,999 | +257,999 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,146,924 | 252,371 | -894,553 | 0.01 | 0.00 | -0.01 | sell |
| Cerity Partners LLC | 220,201 | 239,146 | +18,945 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 237,605 | 235,689 | -1,916 | 0.11 | 0.08 | -0.04 | sell |
| SIMPLEX TRADING, LLC | 140,424 | 215,462 | +75,038 | 0.01 | 0.02 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 203,724 | +203,724 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 162,821 | +162,821 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 162,159 | +162,159 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,400 | 162,113 | +50,713 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 0 | 141,000 | +141,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 903,611 | 134,729 | -768,882 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 48,225 | 133,701 | +85,476 | 0.00 | 0.01 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 127,500 | +127,500 | 0.00 | 0.01 | +0.01 | buy |
| Massar Capital Management, LP | 51,556 | 117,000 | +65,444 | 0.11 | 0.14 | +0.02 | buy |
| Bank of New York Mellon Corp | 99,889 | 111,040 | +11,151 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 227,002 | 105,182 | -121,820 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 46,760 | 102,680 | +55,920 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 69,285 | 91,179 | +21,894 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 99,922 | 81,406 | -18,516 | 0.02 | 0.02 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 103,216 | 78,216 | -25,000 | 0.01 | 0.01 | -0.00 | sell |
| Ethic Inc. | 61,723 | 75,397 | +13,674 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,380 | 74,530 | +12,150 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 250,295 | 71,423 | -178,872 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 84,860 | 70,893 | -13,967 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 67,358 | 68,871 | +1,513 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 100,897 | 68,378 | -32,519 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 57,261 | 64,863 | +7,602 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 64,279 | +64,279 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 31,354 | 56,257 | +24,903 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 39,031 | 55,001 | +15,970 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 54,400 | +54,400 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 167,404 | 52,369 | -115,035 | 0.02 | 0.01 | -0.01 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 146,284 | 49,073 | -97,211 | 0.34 | 0.12 | -0.22 | sell |
| Pale Fire Capital SE | 37,518 | 45,218 | +7,700 | 0.01 | 0.02 | +0.00 | buy |
| Next Level Private LLC | 20,000 | 41,700 | +21,700 | 0.02 | 0.06 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 29,559 | 38,440 | +8,881 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 38,091 | +38,091 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 19,853 | 37,771 | +17,918 | 0.02 | 0.05 | +0.03 | buy |
| CWM, LLC | 32,652 | 36,013 | +3,361 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 35,695 | 35,856 | +161 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 33,000 | 33,000 | 0 | 0.10 | 0.10 | +0.00 | hold |
| Fi3 FINANCIAL ADVISORS, LLC | 24,172 | 29,240 | +5,068 | 0.03 | 0.03 | +0.01 | buy |
| MetLife Investment Management, LLC | 26,359 | 25,707 | -652 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stonepine Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.07 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,301 | 22,970 | +1,669 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,117 | 21,843 | -2,274 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 25,963 | 21,220 | -4,743 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 19,515 | +19,515 | 0.00 | 0.00 | +0.00 | buy |
| Ellevest, Inc. | 0 | 18,828 | +18,828 | 0.00 | 0.01 | +0.01 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 13,629 | 18,248 | +4,619 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,204 | 17,757 | +2,553 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 17,533 | +17,533 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,165 | 15,550 | -615 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,860 | 15,003 | +2,143 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 13,830 | 14,353 | +523 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,082 | 13,726 | +4,644 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 13,444 | 13,586 | +142 | 0.00 | 0.00 | -0.00 | buy |
| Cherry Tree Wealth Management, LLC | 10,618 | 13,264 | +2,646 | 0.01 | 0.01 | +0.00 | buy |
| B.O.S.S. Retirement Advisors, LLC | 0 | 12,719 | +12,719 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 11,070 | 11,088 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 10,925 | +10,925 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,867 | 10,867 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pallas Capital Advisors LLC | 0 | 10,776 | +10,776 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 10,573 | 10,573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 10,157 | +10,157 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,770 | 10,146 | +4,376 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 7,900 | 7,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,619 | 6,619 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 41,900 | 5,275 | -36,625 | 0.00 | 0.00 | -0.00 | sell |