| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,291,701 | 2,218,868 | +927,167 | 0.06 | 0.12 | 0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 383,260 | 994,323 | +611,063 | 0.20 | 0.50 | 0.00 | buy |
| ALGERT GLOBAL LLC | 75,760 | 147,843 | +72,083 | 0.07 | 0.17 | 0.00 | buy |
| Rafferty Asset Management, LLC | 167,795 | 239,208 | +71,413 | 0.02 | 0.03 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 19,788 | 55,359 | +35,571 | 0.04 | 0.14 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 107,542 | 93,186 | +14,356 | 0.01 | 0.01 | +0.00 | sell |
| TWINBEECH CAPITAL LP | 24,161 | 34,468 | +10,307 | 0.01 | 0.02 | 0.00 | buy |
| PROFUND ADVISORS LLC | 27,890 | 37,475 | +9,585 | 0.03 | 0.04 | 0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 180,496 | 188,743 | +8,247 | 0.03 | 0.04 | 0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 91,153 | 97,160 | +6,007 | 0.02 | 0.02 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 106,154 | 109,330 | +3,176 | 0.18 | 0.23 | 0.00 | buy |
| ALPS ADVISORS INC | 40,072 | 41,099 | +1,027 | 0.01 | 0.01 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 34,046 | 34,895 | +849 | 0.04 | 0.05 | 0.00 | buy |
| FRANKLIN STREET ADVISORS INC /NC | 11,720 | 11,470 | +250 | 0.02 | 0.02 | 0.00 | sell |
| Twin Lakes Capital Management, LLC | 62,941 | 62,819 | -122 | 0.99 | 1.23 | +0.24 | sell |
| TD ASSET MANAGEMENT INC | 110,800 | 108,452 | -2,348 | 0.00 | 0.00 | +0.00 | sell |
| Inspire Investing, LLC | 16,782 | 12,340 | -4,442 | 0.04 | 0.04 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 823,740 | 819,296 | -4,444 | 0.00 | 0.00 | +0.00 | sell |
| Bellevue Group AG | 30,000 | 19,146 | -10,854 | 0.01 | 0.01 | -0.00 | sell |
| BVF INC/IL | 5,744,848 | 3,755,990 | -1,988,858 | 3.30 | 2.99 | -0.31 | sell |