| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 819,296 | 1,209,542 | +390,246 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 994,323 | 1,268,735 | +274,412 | 0.50 | 1.05 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,218,868 | 2,001,342 | +217,526 | 0.12 | 0.13 | 0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 188,743 | 382,336 | +193,593 | 0.04 | 0.05 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 109,330 | 68,231 | +41,099 | 0.23 | 0.15 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 108,452 | 148,302 | +39,850 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 55,359 | 25,029 | +30,330 | 0.14 | 0.07 | 0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 21,449 | 48,127 | +26,678 | 0.05 | 0.09 | 0.00 | buy |
| PROFUND ADVISORS LLC | 37,475 | 14,529 | +22,946 | 0.04 | 0.02 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 93,186 | 82,791 | +10,395 | 0.01 | 0.01 | +0.00 | sell |
| Opaleye Management Inc. | 112,700 | 105,000 | +7,700 | 0.71 | 0.83 | +0.12 | sell |
| ALPS ADVISORS INC | 41,099 | 45,772 | +4,673 | 0.01 | 0.01 | 0.00 | buy |
| ALGERT GLOBAL LLC | 147,843 | 152,079 | +4,236 | 0.17 | 0.18 | 0.00 | buy |
| AlphaQuest LLC | 5,900 | 2,431 | +3,469 | 0.03 | 0.01 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 34,895 | 37,880 | +2,985 | 0.05 | 0.07 | 0.00 | buy |
| Twin Lakes Capital Management, LLC | 62,819 | 62,439 | -380 | 1.23 | 1.48 | +0.25 | sell |
| Inspire Investing, LLC | 12,340 | 10,234 | -2,106 | 0.04 | 0.04 | +0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 97,160 | 93,479 | -3,681 | 0.02 | 0.03 | +0.00 | sell |
| Bellevue Group AG | 19,146 | 15,146 | -4,000 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 239,208 | 75,270 | -163,938 | 0.03 | 0.01 | -0.02 | sell |
| BVF INC/IL | 3,755,990 | 3,319,290 | -436,700 | 2.99 | 3.22 | +0.24 | sell |