| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,778,188 | 5,778,188 | 0 | 1.13 | 1.38 | +0.24 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,535,869 | 4,735,963 | +3,200,094 | 0.01 | 0.02 | +0.02 | buy |
| MPM BioImpact LLC | 0 | 4,096,619 | +4,096,619 | 0.00 | 3.72 | +3.72 | buy |
| VANGUARD GROUP INC | 2,890,000 | 3,022,790 | +132,790 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 2,001,727 | 2,001,727 | 0 | 0.97 | 1.26 | +0.29 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,467,796 | 2,000,000 | -2,467,796 | 0.04 | 0.02 | -0.02 | sell |
| BAILLIE GIFFORD & CO | 1,866,850 | 1,846,906 | -19,944 | 0.01 | 0.01 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 1,202,431 | 1,790,051 | +587,620 | 0.73 | 1.24 | +0.51 | buy |
| Samsara BioCapital, LLC | 1,675,579 | 1,675,579 | 0 | 1.12 | 1.46 | +0.35 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,140,760 | 1,308,884 | +168,124 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,259,237 | 1,286,316 | +27,079 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 923,029 | 1,204,253 | +281,224 | 0.02 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,161,465 | 1,196,723 | +35,258 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 420,649 | 1,165,466 | +744,817 | 1.27 | 4.94 | +3.67 | buy |
| Schonfeld Strategic Advisors LLC | 338,600 | 1,123,100 | +784,500 | 0.01 | 0.05 | +0.04 | buy |
| Eversept Partners, LP | 1,056,461 | 1,091,419 | +34,958 | 0.44 | 0.46 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 340,283 | 1,069,522 | +729,239 | 0.01 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,060,582 | 802,735 | -257,847 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 451,692 | 785,204 | +333,512 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 239,800 | 671,100 | +431,300 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 223,924 | 549,366 | +325,442 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 481,184 | 486,384 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 655,797 | 485,797 | -170,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 323,192 | 485,764 | +162,572 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 898,234 | 440,422 | -457,812 | 0.03 | 0.02 | -0.01 | sell |
| CITADEL ADVISORS LLC | 131,925 | 340,741 | +208,816 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 283,079 | 334,079 | +51,000 | 0.29 | 0.43 | +0.14 | buy |
| Verition Fund Management LLC | 622,873 | 283,621 | -339,252 | 0.03 | 0.02 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 170,200 | 275,700 | +105,500 | 0.02 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 285,696 | 260,696 | -25,000 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 378,340 | 255,057 | -123,283 | 0.05 | 0.04 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 0 | 241,643 | +241,643 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 196,517 | 196,517 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Propel Bio Management, LLC | 195,000 | 195,000 | 0 | 0.69 | 0.64 | -0.05 | hold |
| Tejara Capital Ltd | 226,953 | 194,418 | -32,535 | 0.41 | 0.41 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 76,126 | 193,671 | +117,545 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 119,088 | 190,633 | +71,545 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 262,624 | 184,685 | -77,939 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,876 | 160,876 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 131,242 | 149,005 | +17,763 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 126,459 | +126,459 | 0.00 | 0.03 | +0.03 | buy |
| Simplify Asset Management Inc. | 120,000 | 120,000 | 0 | 0.08 | 0.06 | -0.01 | hold |
| FMR LLC | 85,587 | 112,322 | +26,735 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 38,224 | 111,955 | +73,731 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 111,197 | +111,197 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,369 | 98,227 | +81,858 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 61,778 | 96,657 | +34,879 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 91,589 | 94,164 | +2,575 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 82,988 | 88,896 | +5,908 | 0.08 | 0.07 | -0.01 | buy |
| Engineers Gate Manager LP | 56,580 | 80,570 | +23,990 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 132,059 | 79,738 | -52,321 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 169,220 | 76,420 | -92,800 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 75,300 | 75,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 105,687 | 74,639 | -31,048 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 43,474 | 73,615 | +30,141 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 35,856 | 71,056 | +35,200 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 0 | 69,678 | +69,678 | 0.00 | 0.35 | +0.35 | buy |
| Aberdeen Group plc | 69,389 | 69,389 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lighthouse Investment Partners, LLC | 0 | 66,585 | +66,585 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 59,591 | 64,639 | +5,048 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 16,766 | 63,157 | +46,391 | 0.01 | 0.03 | +0.02 | buy |
| CHASE INVESTMENT COUNSEL CORP | 0 | 57,700 | +57,700 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF AMERICA CORP /DE/ | 111,090 | 57,397 | -53,693 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 52,399 | 55,454 | +3,055 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 50,044 | +50,044 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 66,140 | 48,742 | -17,398 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 44,019 | +44,019 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 13,899 | 37,282 | +23,383 | 0.01 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 83,626 | 35,822 | -47,804 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 35,690 | 35,690 | 0 | 0.03 | 0.03 | +0.01 | hold |
| DEUTSCHE BANK AG\ | 32,568 | 33,791 | +1,223 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 29,845 | 30,947 | +1,102 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,380 | 30,284 | +1,904 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 29,896 | 30,017 | +121 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,173 | 27,367 | +4,194 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 30,624 | 26,200 | -4,424 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,748 | 25,861 | +113 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 23,761 | +23,761 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 23,291 | +23,291 | 0.00 | 0.01 | +0.01 | buy |
| Pathstone Holdings, LLC | 0 | 22,813 | +22,813 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 40,779 | 21,193 | -19,586 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 26,021 | 20,055 | -5,966 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 19,899 | 18,645 | -1,254 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,449 | 18,027 | +3,578 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 16,925 | +16,925 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 16,386 | +16,386 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 641,684 | 15,000 | -626,684 | 0.02 | 0.00 | -0.02 | sell |
| STRS OHIO | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,639 | 13,418 | -221 | 0.00 | 0.00 | +0.00 | sell |
| Diversified Trust Co | 11,189 | 13,031 | +1,842 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,273 | 12,293 | -4,980 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 12,057 | +12,057 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,673 | 11,583 | +2,910 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,943 | +10,943 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 53,535 | 10,858 | -42,677 | 0.02 | 0.00 | -0.02 | sell |
| OSAIC HOLDINGS, INC. | 10,250 | 10,850 | +600 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 8,820 | 8,798 | -22 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,900 | 6,124 | -3,776 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 4,967 | 4,967 | 0 | 0.00 | 0.00 | +0.00 | hold |