| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,434,637 | +4,434,637 | 0.00 | 0.05 | +0.05 | buy |
| Kynam Capital Management, LP | 3,641,447 | 5,441,447 | +1,800,000 | 0.44 | 0.30 | -0.14 | buy |
| Eversept Partners, LP | 694,408 | 2,292,261 | +1,597,853 | 0.13 | 0.17 | +0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,751,925 | 3,134,586 | +1,382,661 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 114,587 | 1,320,917 | +1,206,330 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 30,000 | 1,030,000 | +1,000,000 | 0.05 | 0.69 | +0.64 | buy |
| Affinity Asset Advisors, LLC | 0 | 752,722 | +752,722 | 0.00 | 0.08 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 405,618 | 703,155 | +297,537 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 64,045 | 301,407 | +237,362 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 4,208,500 | 4,395,244 | +186,744 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 94,932 | +94,932 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 45,260 | 136,623 | +91,363 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 271,337 | 352,949 | +81,612 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 75,066 | +75,066 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 547,510 | 604,580 | +57,070 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 38,749 | 92,139 | +53,390 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 40,432 | 84,907 | +44,475 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 0 | 39,065 | +39,065 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 36,168 | 72,540 | +36,372 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,854,017 | 1,889,272 | +35,255 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 32,716 | +32,716 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 2,570,000 | 2,600,000 | +30,000 | 0.28 | 0.12 | -0.16 | buy |
| LPL Financial LLC | 362,232 | 389,932 | +27,700 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,778 | +26,778 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 25,000 | 50,000 | +25,000 | 0.00 | 0.00 | -0.00 | buy |
| OneDigital Investment Advisors LLC | 0 | 24,099 | +24,099 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 22,850 | +22,850 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 18,164 | +18,164 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 17,199 | +17,199 | 0.00 | 0.00 | +0.00 | buy |
| Prime Capital Investment Advisors, LLC | 0 | 17,111 | +17,111 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 15,143 | +15,143 | 0.00 | 0.00 | +0.00 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 0 | 12,907 | +12,907 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 10,414 | 22,056 | +11,642 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30,199 | 36,893 | +6,694 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,711 | 13,707 | +5,996 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 150,758 | 155,235 | +4,477 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,148 | 36,487 | +4,339 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 21,809 | 25,166 | +3,357 | 0.00 | 0.00 | -0.00 | buy |
| Gen-Wealth Partners Inc | 1,042 | 4,042 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 46,886 | 48,998 | +2,112 | 0.00 | 0.00 | -0.00 | buy |
| Shay Capital LLC | 203,601 | 205,620 | +2,019 | 0.09 | 0.04 | -0.05 | buy |
| CITIGROUP INC | 63,924 | 65,305 | +1,381 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 1,304 | +1,304 | 0.00 | 0.00 | +0.00 | buy |
| Accredited Wealth Management, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,964 | 2,825 | +861 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 61 | 857 | +796 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 157,683 | 158,037 | +354 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,731 | 1,982 | +251 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,881 | 30,993 | +112 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 2 | 3 | +1 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 95,150 | 95,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,622 | 6,622 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,932 | 5,932 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 96,370 | 96,370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 2,000,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 437,079 | 437,079 | 0 | 0.20 | 0.08 | -0.12 | hold |
| PEAK6 LLC | 21,306 | 21,306 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AdvisorNet Financial, Inc | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Diversified Trust Co | 12,610 | 12,610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,462,495 | 7,462,495 | 0 | 0.51 | 0.20 | -0.31 | hold |
| Parallel Advisors, LLC | 465 | 465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AJU IB Investment Co., Ltd. | 175,000 | 175,000 | 0 | 0.31 | 0.14 | -0.18 | hold |
| Bogart Wealth, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 69,389 | 69,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 2,196,814 | 2,196,814 | 0 | 0.55 | 0.25 | -0.30 | hold |
| Concord Wealth Partners | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 16,570 | 16,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Merck & Co., Inc. | 2,723,509 | 2,723,509 | 0 | 1.94 | 1.08 | -0.86 | hold |
| SEI INVESTMENTS CO | 56,347 | 56,347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 7,073 | 7,073 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,625 | 13,625 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 152,800 | 152,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,273 | 17,273 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 9 | 0 | -9 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 30 | 0 | -30 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 58 | 0 | -58 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,748 | 2,676 | -72 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 350 | 0 | -350 | 0.00 | 0.00 | -0.00 | sell |
| Aquilo Capital Management, LLC | 498 | 0 | -498 | 0.00 | 0.00 | -0.00 | sell |
| Smartleaf Asset Management LLC | 511 | 0 | -511 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 40,698 | 40,104 | -594 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,484 | 16,540 | -944 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 1,137 | 0 | -1,137 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 1,190 | 0 | -1,190 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 2,780 | 1,471 | -1,309 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,350 | 0 | -1,350 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 142,186 | 140,362 | -1,824 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 2,250 | 225 | -2,025 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,714,422 | 1,712,115 | -2,307 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 636,920 | 633,923 | -2,997 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 63,554 | 60,463 | -3,091 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 126,698 | 122,816 | -3,882 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 66,646 | 61,267 | -5,379 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 26,961 | 21,441 | -5,520 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 217,627 | 209,222 | -8,405 | 0.00 | 0.00 | -0.00 | sell |
| Forvis Mazars Wealth Advisors, LLC | 12,840 | 0 | -12,840 | 0.00 | 0.00 | -0.00 | sell |