| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 1,251,788 | +1,251,788 | 0.00 | 0.99 | +0.99 | buy |
| Samsara BioCapital, LLC | 204,503 | 1,062,872 | +858,369 | 0.24 | 2.57 | +2.33 | buy |
| ORBIMED ADVISORS LLC | 0 | 801,144 | +801,144 | 0.00 | 0.44 | +0.44 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 715,307 | +715,307 | 0.00 | 0.35 | +0.35 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 715,307 | +715,307 | 0.00 | 0.19 | +0.19 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 715,307 | +715,307 | 0.00 | 0.29 | +0.29 | buy |
| Point72 Asset Management, L.P. | 179,088 | 692,111 | +513,023 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 0 | 457,441 | +457,441 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 67,077 | 524,441 | +457,364 | 0.06 | 0.79 | +0.73 | buy |
| Kynam Capital Management, LP | 479,590 | 872,558 | +392,968 | 0.36 | 1.38 | +1.02 | buy |
| UBS Group AG | 0 | 392,871 | +392,871 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 748,382 | 1,069,519 | +321,137 | 0.62 | 1.56 | +0.94 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 230,049 | 465,792 | +235,743 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 67,451 | 269,425 | +201,974 | 0.53 | 4.77 | +4.24 | buy |
| Velan Capital Investment Management LP | 312,000 | 512,160 | +200,160 | 2.10 | 7.99 | +5.89 | buy |
| MARSHALL WACE, LLP | 85,615 | 222,634 | +137,019 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 117,437 | 232,684 | +115,247 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 83,979 | 171,386 | +87,407 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 32,085 | 117,537 | +85,452 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 84,902 | +84,902 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 71,530 | +71,530 | 0.00 | 0.09 | +0.09 | buy |
| Trexquant Investment LP | 0 | 34,343 | +34,343 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 23,295 | +23,295 | 0.00 | 0.11 | +0.11 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 18,873 | +18,873 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,791 | +18,791 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 14,379 | 33,166 | +18,787 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,492 | 65,176 | +18,684 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 34,266 | 52,118 | +17,852 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,043 | 18,845 | +17,802 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 14,768 | +14,768 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 0 | 12,520 | +12,520 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 12,385 | +12,385 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 15,669 | 27,187 | +11,518 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 10,577 | +10,577 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 8,203 | +8,203 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 7,411 | +7,411 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 22,945 | 27,760 | +4,815 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,970 | 17,165 | +195 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 62 | +62 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 3 | 41 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 15,272 | 15,272 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 200,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 111 | 111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| State of Tennessee, Department of Treasury | 7,400 | 7,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 190,671 | 190,671 | 0 | 0.29 | 0.63 | +0.33 | hold |
| Parallel Advisors, LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AJU IB Investment Co., Ltd. | 17,500 | 17,500 | 0 | 0.89 | 1.43 | +0.54 | hold |
| Bogart Wealth, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Avion Wealth | 72 | 72 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 182 | 182 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 23 | 23 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 56 | 56 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Merck & Co., Inc. | 272,351 | 272,351 | 0 | 1.14 | 1.94 | +0.80 | hold |
| NISA INVESTMENT ADVISORS, LLC | 44 | 44 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 35,305 | 35,295 | -10 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 31 | 19 | -12 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,108 | 1,050 | -58 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 1,499 | 983 | -516 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 337,953 | 335,813 | -2,140 | 0.01 | 0.01 | +0.01 | sell |
| OMERS ADMINISTRATION Corp | 11,023 | 8,700 | -2,323 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 18,034 | 8,605 | -9,429 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 17,580 | 0 | -17,580 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 24,255 | 0 | -24,255 | 0.05 | 0.00 | -0.05 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 122,865 | 97,824 | -25,041 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 89,067 | 25,822 | -63,245 | 0.09 | 0.04 | -0.05 | sell |
| Eversept Partners, LP | 193,571 | 73,161 | -120,410 | 0.13 | 0.12 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 139,617 | 0 | -139,617 | 0.08 | 0.00 | -0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 418,196 | 210,378 | -207,818 | 0.00 | 0.00 | +0.00 | sell |
| Vestal Point Capital, LP | 243,000 | 0 | -243,000 | 0.10 | 0.00 | -0.10 | sell |