| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 260,696 | 4,447,634 | +4,186,938 | 0.00 | 0.04 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,778,188 | 7,708,690 | +1,930,502 | 1.38 | 0.92 | -0.46 | buy |
| CITADEL ADVISORS LLC | 340,741 | 1,619,907 | +1,279,166 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,091,419 | 1,739,129 | +647,710 | 0.46 | 0.39 | -0.07 | buy |
| VANGUARD GROUP INC | 3,022,790 | 3,555,340 | +532,550 | 0.00 | 0.00 | -0.00 | buy |
| Samsara BioCapital, LLC | 1,675,579 | 2,196,814 | +521,235 | 1.46 | 1.35 | -0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,286,316 | 1,724,941 | +438,625 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,204,253 | 1,574,958 | +370,705 | 0.02 | 0.01 | -0.01 | buy |
| STATE STREET CORP | 1,196,723 | 1,565,307 | +368,584 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,822 | 283,516 | +247,694 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 802,735 | 1,049,372 | +246,637 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 235,397 | +235,397 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 485,797 | 719,497 | +233,700 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 0 | 230,149 | +230,149 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 15,000 | 165,300 | +150,300 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 785,204 | 907,503 | +122,299 | 0.02 | 0.01 | -0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 126,459 | 225,367 | +98,908 | 0.03 | 0.02 | -0.02 | buy |
| FRANKLIN RESOURCES INC | 0 | 95,423 | +95,423 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 184,685 | 272,719 | +88,034 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 196,517 | 271,337 | +74,820 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 70,614 | +70,614 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 63,785 | +63,785 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 60,761 | +60,761 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,876 | 216,828 | +55,952 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 43,426 | +43,426 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 39,186 | +39,186 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 112,322 | 151,340 | +39,018 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 57,397 | 95,489 | +38,092 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 149,005 | 181,401 | +32,396 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 76,420 | 105,310 | +28,890 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 2,001,727 | 2,023,683 | +21,956 | 1.26 | 0.62 | -0.64 | buy |
| RHUMBLINE ADVISERS | 94,164 | 116,099 | +21,935 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 75,300 | 96,370 | +21,070 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 255,057 | 275,057 | +20,000 | 0.04 | 0.02 | -0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,858 | 29,989 | +19,131 | 0.00 | 0.01 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 19,073 | +19,073 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 30,284 | 48,590 | +18,306 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 485,764 | 503,603 | +17,839 | 0.01 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 111,955 | 128,231 | +16,276 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 486,384 | 502,648 | +16,264 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 671,100 | 686,500 | +15,400 | 0.01 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,367 | 41,857 | +14,490 | 0.00 | 0.00 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 13,661 | +13,661 | 0.00 | 0.00 | +0.00 | buy |
| Forvis Mazars Wealth Advisors, LLC | 0 | 12,840 | +12,840 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,044 | 62,530 | +12,486 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 11,725 | +11,725 | 0.00 | 0.01 | +0.01 | buy |
| Tejara Capital Ltd | 194,418 | 203,145 | +8,727 | 0.41 | 0.22 | -0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,027 | 26,255 | +8,228 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,055 | 27,966 | +7,911 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 11,583 | 19,189 | +7,606 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,624 | 11,881 | +7,257 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,861 | 32,943 | +7,082 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 55,454 | 60,858 | +5,404 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 10,943 | 16,316 | +5,373 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,293 | 17,273 | +4,980 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,064 | 4,714 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 2,822 | +2,822 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,790,051 | 1,792,740 | +2,689 | 1.24 | 0.72 | -0.53 | buy |
| Legal & General Group Plc | 4,960 | 7,073 | +2,113 | 0.00 | 0.00 | -0.00 | buy |
| BAILLIE GIFFORD & CO | 1,846,906 | 1,848,751 | +1,845 | 0.01 | 0.00 | -0.00 | buy |
| CWM, LLC | 47 | 1,546 | +1,499 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Gen-Wealth Partners Inc | 0 | 1,042 | +1,042 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 10,850 | 11,836 | +986 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 657 | +657 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 22,813 | 23,459 | +646 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 354 | +354 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,418 | 13,625 | +207 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 8,798 | 8,906 | +108 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 26,200 | 26,261 | +61 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 96,657 | 96,657 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,967 | 4,967 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 2,000,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| AdvisorNet Financial, Inc | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Diversified Trust Co | 13,031 | 13,031 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vontobel Holding Ltd. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 465 | 465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bogart Wealth, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 69,389 | 69,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 2,250 | 2,250 | 0 | 0.01 | 0.00 | -0.00 | hold |
| COMERICA BANK | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,964 | 1,964 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,124 | 5,932 | -192 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 285 | 0 | -285 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 35,690 | 35,360 | -330 | 0.03 | 0.02 | -0.01 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,632 | 0 | -1,632 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 334,079 | 329,579 | -4,500 | 0.43 | 0.23 | -0.20 | sell |
| US BANCORP \DE\ | 17,000 | 12,000 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 33,791 | 28,177 | -5,614 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 37,282 | 31,311 | -5,971 | 0.02 | 0.01 | -0.01 | sell |
| SG Americas Securities, LLC | 21,193 | 14,772 | -6,421 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 73,615 | 66,812 | -6,803 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 18,645 | 10,853 | -7,792 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 23,761 | 12,829 | -10,932 | 0.01 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 12,057 | 0 | -12,057 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 16,386 | 0 | -16,386 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 71,056 | 54,195 | -16,861 | 0.01 | 0.00 | -0.01 | sell |