| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,462,495 | 6,488,324 | -974,171 | 0.20 | 0.17 | -0.02 | sell |
| Kynam Capital Management, LP | 5,441,447 | 5,088,099 | -353,348 | 0.30 | 0.39 | +0.09 | sell |
| MILLENNIUM MANAGEMENT LLC | 703,155 | 4,732,243 | +4,029,088 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,395,244 | 4,115,250 | -279,994 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 1,030,000 | 3,060,000 | +2,030,000 | 0.69 | 2.19 | +1.50 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 3,134,586 | 3,042,238 | -92,348 | 0.01 | 0.00 | -0.00 | sell |
| Merck & Co., Inc. | 2,723,509 | 2,723,509 | 0 | 1.08 | 0.90 | -0.18 | hold |
| Vestal Point Capital, LP | 2,600,000 | 2,600,000 | 0 | 0.12 | 0.10 | -0.02 | hold |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 2,561,586 | +2,361,586 | 0.01 | 0.09 | +0.09 | buy |
| Eversept Partners, LP | 2,292,261 | 2,292,261 | 0 | 0.17 | 0.16 | -0.00 | hold |
| Samsara BioCapital, LLC | 2,196,814 | 2,196,814 | 0 | 0.25 | 0.32 | +0.07 | hold |
| BlackRock, Inc. | 6,204,784 | 2,107,008 | -4,097,776 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 2,000,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 0 | 1,618,884 | +1,618,884 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,320,917 | 1,012,716 | -308,201 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 868,997 | 913,197 | +44,200 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,889,272 | 816,915 | -1,072,357 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 752,722 | 752,722 | 0 | 0.08 | 0.08 | +0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 688,850 | +688,850 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 817,479 | 628,473 | -189,006 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 437,079 | 437,079 | 0 | 0.08 | 0.09 | +0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,712,115 | 405,748 | -1,306,367 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 389,932 | 370,748 | -19,184 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 352,949 | 352,949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 1,682,339 | 342,652 | -1,339,687 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 205,620 | 259,889 | +54,269 | 0.04 | 0.04 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 234,431 | +234,431 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 221,829 | +221,829 | 0.00 | 0.00 | +0.00 | buy |
| AJU IB Investment Co., Ltd. | 175,000 | 175,000 | 0 | 0.14 | 0.14 | +0.00 | hold |
| JPMORGAN CHASE & CO | 301,407 | 173,477 | -127,930 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 633,923 | 167,734 | -466,189 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 0 | 160,000 | +160,000 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 75,066 | 123,319 | +48,253 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 115,401 | +115,401 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 95,881 | 115,068 | +19,187 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 39,065 | 105,437 | +66,372 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 92,139 | 103,320 | +11,181 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 95,150 | 95,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 26,778 | 85,509 | +58,731 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 84,472 | +84,472 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 69,389 | 69,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 66,591 | +66,591 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 240,900 | 66,300 | -174,600 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 61,068 | +61,068 | 0.00 | 0.01 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 22,056 | 60,617 | +38,561 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 32,716 | 56,657 | +23,941 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 52,416 | +52,416 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalyst Funds Management Pty Ltd | 0 | 38,500 | +38,500 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 604,580 | 35,500 | -569,080 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 65,305 | 28,528 | -36,777 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,707 | 24,879 | +11,172 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 60,463 | 24,739 | -35,724 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 24,099 | 24,099 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 22,571 | +22,571 | 0.00 | 0.00 | +0.00 | buy |
| PEAK6 LLC | 21,306 | 21,306 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 17,199 | 21,201 | +4,002 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,540 | 16,964 | +424 | 0.00 | 0.00 | +0.00 | buy |
| Callan Family Office, LLC | 0 | 16,177 | +16,177 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 13,630 | +13,630 | 0.00 | 0.00 | +0.00 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 12,907 | 12,907 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,900 | 12,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ground Swell Capital, LLC | 0 | 12,683 | +12,683 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 61,549 | 11,639 | -49,910 | 0.00 | 0.00 | -0.00 | sell |
| Pallas Capital Advisors LLC | 0 | 11,110 | +11,110 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 10,998 | +10,998 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 10,947 | +10,947 | 0.00 | 0.00 | +0.00 | buy |
| Revolve Wealth Partners, LLC | 0 | 10,312 | +10,312 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 10,170 | +10,170 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 116,286 | 6,618 | -109,668 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 6,078 | +6,078 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 4,113 | +4,113 | 0.00 | 0.00 | +0.00 | buy |
| Gen-Wealth Partners Inc | 4,042 | 4,042 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,676 | 3,263 | +587 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 155,235 | 2,398 | -152,837 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,982 | 1,982 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 857 | 1,471 | +614 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 1,304 | 1,304 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 0 | 1,259 | +1,259 | 0.00 | 0.00 | +0.00 | buy |
| Accredited Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rise Advisors, LLC | 0 | 769 | +769 | 0.00 | 0.00 | +0.00 | buy |
| Avion Wealth | 0 | 716 | +716 | 0.00 | 0.00 | 0.00 | buy |
| Rialto Wealth Management, LLC | 0 | 707 | +707 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 559 | +559 | 0.00 | 0.00 | +0.00 | buy |
| Bogart Wealth, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 465 | 465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 0 | 121 | +121 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 3 | 2 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 158,037 | 0 | -158,037 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,622 | 0 | -6,622 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 18,164 | 0 | -18,164 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 36,487 | 0 | -36,487 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,932 | 0 | -5,932 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 72,540 | 0 | -72,540 | 0.00 | 0.00 | -0.00 | sell |