| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 715,307 | 1,304,846 | +589,539 | 0.35 | 0.67 | +0.32 | buy |
| BVF INC/IL | 1,251,788 | 1,251,788 | 0 | 0.99 | 1.06 | +0.07 | hold |
| Affinity Asset Advisors, LLC | 1,069,519 | 1,172,487 | +102,968 | 1.56 | 1.90 | +0.34 | buy |
| BlackRock, Inc. | 232,684 | 1,122,655 | +889,971 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 1,062,872 | 1,062,872 | 0 | 2.57 | 2.90 | +0.33 | hold |
| Kynam Capital Management, LP | 872,558 | 872,558 | 0 | 1.38 | 1.60 | +0.22 | hold |
| ORBIMED ADVISORS LLC | 801,144 | 743,944 | -57,200 | 0.44 | 0.47 | +0.03 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 465,792 | 711,162 | +245,370 | 0.02 | 0.04 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 715,307 | 585,262 | -130,045 | 0.29 | 0.26 | -0.04 | sell |
| Velan Capital Investment Management LP | 512,160 | 512,160 | 0 | 7.99 | 10.42 | +2.43 | hold |
| Woodline Partners LP | 457,441 | 458,029 | +588 | 0.04 | 0.05 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 524,441 | 404,014 | -120,427 | 0.79 | 0.63 | -0.15 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 171,386 | 389,692 | +218,306 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 335,813 | 373,839 | +38,026 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 210,378 | 365,972 | +155,594 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 52,118 | 305,979 | +253,861 | 0.00 | 0.00 | +0.00 | buy |
| Merck & Co., Inc. | 0 | 272,351 | +272,351 | 0.00 | 1.72 | +1.72 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 269,425 | 270,251 | +826 | 4.77 | 6.25 | +1.48 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 244,669 | +244,669 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 692,111 | 237,827 | -454,284 | 0.03 | 0.01 | -0.02 | sell |
| UBS Group AG | 392,871 | 208,512 | -184,359 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 65,176 | 201,688 | +136,512 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 222,634 | 175,246 | -47,388 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 0 | 167,997 | +167,997 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 159,627 | +159,627 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 27,187 | 149,216 | +122,029 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 33,166 | 125,933 | +92,767 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 106,610 | +106,610 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 117,537 | 101,965 | -15,572 | 0.00 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 0 | 94,767 | +94,767 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 97,824 | 86,324 | -11,500 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 17,165 | 57,305 | +40,140 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,879 | +55,879 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 55,539 | +55,539 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 8,203 | 52,169 | +43,966 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 49,302 | +49,302 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,577 | 49,302 | +38,725 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 12,520 | 45,020 | +32,500 | 0.01 | 0.04 | +0.03 | buy |
| Bank of New York Mellon Corp | 0 | 41,369 | +41,369 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 139 | 36,954 | +36,815 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 18,873 | 36,140 | +17,267 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 35,295 | 35,295 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 30,128 | +30,128 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 34,343 | 27,636 | -6,707 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 111 | 27,383 | +27,272 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 20,628 | +20,628 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 25,822 | 19,749 | -6,073 | 0.04 | 0.04 | +0.00 | sell |
| SEI INVESTMENTS CO | 0 | 16,387 | +16,387 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 16,232 | +16,232 | 0.00 | 0.05 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 0 | 15,563 | +15,563 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 15,272 | 15,272 | 0 | 0.02 | 0.02 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 13,597 | +13,597 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 13,544 | +13,544 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 9,401 | +9,401 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 9,306 | +9,306 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 0 | 8,939 | +8,939 | 0.00 | 0.05 | +0.05 | buy |
| Lighthouse Investment Partners, LLC | 0 | 8,368 | +8,368 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 18,845 | 7,456 | -11,389 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 7,313 | +7,313 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 7,300 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,001 | +7,001 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 7,411 | 6,569 | -842 | 0.07 | 0.07 | -0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 6,234 | +6,234 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 5,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 4,704 | +4,704 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,462 | +3,462 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,618 | +1,618 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,448 | +1,448 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,050 | 1,339 | +289 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 0 | 866 | +866 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 281 | +281 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 220 | +220 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 201 | +201 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 182 | 182 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 56 | 56 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bogart Wealth, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 72 | 46 | -26 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 44 | 44 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 23 | 23 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 41 | 16 | -25 | 0.00 | 0.00 | +0.00 | sell |
| Steward Partners Investment Advisory, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OMERS ADMINISTRATION Corp | 8,700 | 0 | -8,700 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 0 | -200,000 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 8,605 | 0 | -8,605 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 715,307 | 0 | -715,307 | 0.19 | 0.00 | -0.19 | sell |
| Hudson Bay Capital Management LP | 14,768 | 0 | -14,768 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,902 | 0 | -84,902 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 62 | 0 | -62 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 18,791 | 0 | -18,791 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 7,400 | 0 | -7,400 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 190,671 | 0 | -190,671 | 0.63 | 0.00 | -0.63 | sell |
| JANE STREET GROUP, LLC | 27,760 | 0 | -27,760 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 73,161 | 0 | -73,161 | 0.12 | 0.00 | -0.12 | sell |
| AJU IB Investment Co., Ltd. | 17,500 | 0 | -17,500 | 1.43 | 0.00 | -1.43 | sell |