| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,708,690 | 7,187,495 | -521,195 | 0.92 | 0.89 | -0.03 | sell |
| VANGUARD GROUP INC | 3,555,340 | 4,195,072 | +639,732 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,447,634 | 2,997,453 | -1,450,181 | 0.04 | 0.04 | -0.01 | sell |
| MPM BioImpact LLC | 3,043,346 | 2,832,064 | -211,282 | 1.39 | 1.47 | +0.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 2,250,132 | +250,132 | 0.01 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 2,196,814 | 2,196,814 | 0 | 1.35 | 1.46 | +0.11 | hold |
| CITADEL ADVISORS LLC | 1,619,907 | 2,126,655 | +506,748 | 0.00 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 2,023,683 | 2,066,447 | +42,764 | 0.62 | 0.55 | -0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,361,893 | 2,031,745 | -2,330,148 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,724,941 | 1,856,956 | +132,015 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,739,129 | 1,841,989 | +102,860 | 0.39 | 0.49 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 1,049,372 | 1,746,268 | +696,896 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,792,740 | 1,716,132 | -76,608 | 0.72 | 0.76 | +0.04 | sell |
| STATE STREET CORP | 1,565,307 | 1,647,162 | +81,855 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,574,958 | 1,609,874 | +34,916 | 0.01 | 0.02 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 1,848,751 | 1,519,341 | -329,410 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,085,281 | 980,318 | -104,963 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 719,497 | 828,097 | +108,600 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,050,189 | 821,746 | -228,443 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 814,955 | +814,955 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 762,498 | 762,498 | 0 | 2.15 | 2.97 | +0.82 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 13,661 | 737,670 | +724,009 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 502,648 | 622,428 | +119,780 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 686,500 | 590,900 | -95,600 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 503,603 | 491,765 | -11,838 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 437,051 | +437,051 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 359,919 | +359,919 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 275,057 | 338,222 | +63,165 | 0.02 | 0.03 | +0.01 | buy |
| DAFNA Capital Management LLC | 329,579 | 329,579 | 0 | 0.23 | 0.27 | +0.04 | hold |
| AQR CAPITAL MANAGEMENT LLC | 283,516 | 325,538 | +42,022 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 634,200 | 283,600 | -350,600 | 0.01 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 56,262 | 273,019 | +216,757 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 271,337 | 271,337 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LPL Financial LLC | 230,149 | 269,899 | +39,750 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 216,828 | 251,995 | +35,167 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 907,503 | 244,809 | -662,694 | 0.01 | 0.00 | -0.01 | sell |
| Bank of New York Mellon Corp | 272,719 | 215,049 | -57,670 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 190,300 | +190,300 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 151,340 | 189,041 | +37,701 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 181,401 | 182,226 | +825 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 128,665 | 167,645 | +38,980 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 165,859 | +165,859 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 130,277 | 163,928 | +33,651 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 165,300 | 152,800 | -12,500 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 128,231 | 151,221 | +22,990 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 95,489 | 129,152 | +33,663 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 19,073 | 128,850 | +109,777 | 0.01 | 0.10 | +0.09 | buy |
| PRUDENTIAL FINANCIAL INC | 105,310 | 121,410 | +16,100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 116,099 | 119,378 | +3,279 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 108,192 | +108,192 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 32,356 | 104,200 | +71,844 | 0.01 | 0.03 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 195,700 | 99,200 | -96,500 | 0.01 | 0.01 | -0.01 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 96,657 | 96,657 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 96,370 | 96,370 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 95,423 | 93,235 | -2,188 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,372 | 82,524 | +76,152 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,530 | 82,391 | +19,861 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 60,858 | 81,665 | +20,807 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 66,812 | 72,075 | +5,263 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 69,389 | 69,389 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 70,614 | 68,898 | -1,716 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 63,785 | 65,061 | +1,276 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,189 | 61,140 | +41,951 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 58,936 | +58,936 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 39,186 | 49,713 | +10,527 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 54,195 | 45,260 | -8,935 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,913 | 44,826 | +13,913 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 44,040 | 43,771 | -269 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 28,177 | 42,531 | +14,354 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 41,857 | 42,272 | +415 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 40,985 | +40,985 | 0.00 | 0.08 | +0.08 | buy |
| SG Americas Securities, LLC | 14,772 | 34,662 | +19,890 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,943 | 31,884 | -1,059 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,966 | 31,530 | +3,564 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 48,590 | 30,898 | -17,692 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 30,661 | +30,661 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 26,336 | +26,336 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,255 | 26,255 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 26,261 | 25,129 | -1,132 | 0.00 | 0.00 | +0.00 | sell |
| Pathstone Holdings, LLC | 23,459 | 23,595 | +136 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 22,305 | +22,305 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 21,137 | +21,137 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 35,360 | 18,563 | -16,797 | 0.02 | 0.02 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,273 | 17,273 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 16,316 | 15,467 | -849 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,625 | 13,625 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Diversified Trust Co | 13,031 | 13,031 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Forvis Mazars Wealth Advisors, LLC | 12,840 | 12,840 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,989 | 11,689 | -18,300 | 0.01 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 0 | 11,311 | +11,311 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 11,836 | 10,550 | -1,286 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 1,546 | 9,673 | +8,127 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 9,633 | +9,633 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 8,906 | 8,961 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Gladius Capital Management LP | 0 | 8,084 | +8,084 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 7,073 | 7,073 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,967 | 6,622 | +1,655 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,932 | 5,932 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 4,714 | 4,844 | +130 | 0.00 | 0.00 | +0.00 | buy |