| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,105,132 | 4,467,796 | +1,362,664 | 0.02 | 0.04 | +0.02 | buy |
| Kynam Capital Management, LP | 1,552,675 | 2,001,727 | +449,052 | 0.90 | 0.97 | +0.08 | buy |
| Aquilo Capital Management, LLC | 0 | 420,649 | +420,649 | 0.00 | 1.27 | +1.27 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 302,897 | 655,797 | +352,900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 323,192 | +323,192 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 301,491 | +301,491 | 0.00 | 0.34 | +0.34 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,239,251 | 1,535,869 | +296,618 | 0.00 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 769,638 | 1,056,461 | +286,823 | 0.30 | 0.44 | +0.15 | buy |
| MORGAN STANLEY | 0 | 223,924 | +223,924 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 432,339 | 623,684 | +191,345 | 0.29 | 1.15 | +0.86 | buy |
| Vontobel Holding Ltd. | 450,339 | 641,684 | +191,345 | 0.01 | 0.02 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 170,200 | +170,200 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 773,867 | 923,029 | +149,162 | 0.01 | 0.02 | +0.00 | buy |
| Tejara Capital Ltd | 88,682 | 226,953 | +138,271 | 0.18 | 0.41 | +0.23 | buy |
| Man Group plc | 0 | 119,088 | +119,088 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 13,279 | 105,687 | +92,408 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 48,589 | 131,925 | +83,336 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 369,148 | 451,692 | +82,544 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 76,126 | +76,126 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 73,271 | +73,271 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 62,579 | 132,059 | +69,480 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 69,389 | +69,389 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 104,990 | 169,220 | +64,230 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 20,446 | 82,988 | +62,542 | 0.01 | 0.08 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,197,152 | 1,259,237 | +62,085 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 23,758 | 83,626 | +59,868 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 56,580 | +56,580 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,105,785 | 1,161,465 | +55,680 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 185,200 | 239,800 | +54,600 | 0.00 | 0.00 | +0.00 | buy |
| Aristides Capital LLC | 0 | 50,476 | +50,476 | 0.00 | 0.11 | +0.11 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 330,000 | 378,340 | +48,340 | 0.02 | 0.05 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,935 | 53,535 | +34,600 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 29,845 | +29,845 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 105,580 | 131,242 | +25,662 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 27,771 | 52,399 | +24,628 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 35,973 | 59,591 | +23,618 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,868,762 | 2,890,000 | +21,238 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 89,992 | 111,090 | +21,098 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,182,168 | 1,202,431 | +20,263 | 0.75 | 0.73 | -0.02 | buy |
| Pentwater Capital Management LP | 430,000 | 450,000 | +20,000 | 0.01 | 0.04 | +0.02 | buy |
| Virtu Financial LLC | 0 | 16,766 | +16,766 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 13,903 | +13,903 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,899 | +13,899 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,129,823 | 1,140,760 | +10,937 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 10,250 | +10,250 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 21,386 | 30,624 | +9,238 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 26,764 | 35,856 | +9,092 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 62 | 8,820 | +8,758 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 32,465 | 40,779 | +8,314 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 825 | 8,673 | +7,848 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 37,218 | 43,474 | +6,256 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 80,260 | 85,587 | +5,327 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,517 | 23,173 | +3,656 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,312 | +3,312 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 1,798 | +1,798 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,114 | 14,449 | +1,335 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,701 | 26,021 | +1,320 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 261,451 | 262,624 | +1,173 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 187 | +187 | 0.00 | 0.00 | 0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 61,778 | 61,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,967 | 4,967 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 3,347,946 | 3,347,946 | 0 | 0.31 | 0.36 | +0.05 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 35,690 | 35,690 | 0 | 0.02 | 0.03 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 75,300 | 75,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DAFNA Capital Management LLC | 283,079 | 283,079 | 0 | 0.31 | 0.29 | -0.01 | hold |
| Diversified Trust Co | 11,189 | 11,189 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 28,380 | 28,380 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rubric Capital Management LP | 3,344,810 | 3,344,810 | 0 | 0.49 | 0.54 | +0.05 | hold |
| Bogart Wealth, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,675,579 | 1,675,579 | 0 | 1.78 | 1.12 | -0.66 | hold |
| HighMark Wealth Management LLC | 2,250 | 2,250 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Simplify Asset Management Inc. | 120,000 | 120,000 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Washington Trust Advisors, Inc. | 179 | 179 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 4,960 | 4,960 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fisher Asset Management, LLC | 196,517 | 196,517 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 160,876 | 160,876 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,748 | 25,748 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,273 | 17,273 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 530 | 465 | -65 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 280 | 187 | -93 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,756 | 13,639 | -117 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 30,017 | 29,896 | -121 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 158 | 0 | -158 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 91,898 | 91,589 | -309 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 5,698 | 5,114 | -584 | 0.00 | 0.00 | +0.00 | sell |
| BAILLIE GIFFORD & CO | 1,867,654 | 1,866,850 | -804 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 33,782 | 32,568 | -1,214 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,546 | 0 | -1,546 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,148 | 285 | -1,863 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,953 | 1,086 | -1,867 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 22,150 | 19,899 | -2,251 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,272 | 9,900 | -3,372 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 485,822 | 481,184 | -4,638 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 4,953 | 0 | -4,953 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,128 | 9,396 | -5,732 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 6,387 | 223 | -6,164 | 0.00 | 0.00 | -0.00 | sell |
| Manchester Capital Management LLC | 10,561 | 0 | -10,561 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 76,824 | 66,140 | -10,684 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,770 | 0 | -11,770 | 0.00 | 0.00 | -0.00 | sell |