| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,100,451 | 8,107,782 | +1,007,331 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 8,263,643 | 8,100,351 | -163,292 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 7,516,203 | 7,728,527 | +212,324 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 5,239,711 | 6,321,775 | +1,082,064 | 0.25 | 0.25 | +0.00 | buy |
| ARK Investment Management LLC | 3,939,302 | 3,800,089 | -139,213 | 1.17 | 0.75 | -0.42 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,853,121 | 3,473,772 | -379,349 | 0.02 | 0.02 | -0.00 | sell |
| STATE STREET CORP | 3,158,239 | 3,169,700 | +11,461 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,910,902 | 3,022,502 | +111,600 | 0.02 | 0.02 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 3,226,673 | 2,578,823 | -647,850 | 1.55 | 1.26 | -0.29 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,934,859 | 1,931,400 | -3,459 | 0.00 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 2,263,939 | 1,647,177 | -616,762 | 0.05 | 0.03 | -0.02 | sell |
| Nikko Asset Management Americas, Inc. | 2,261,879 | 1,647,177 | -614,702 | 0.86 | 0.44 | -0.42 | sell |
| GOLDMAN SACHS GROUP INC | 1,048,648 | 1,548,474 | +499,826 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,158,763 | 1,519,710 | +360,947 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,256,893 | 1,404,715 | +147,822 | 0.35 | 0.34 | -0.01 | buy |
| FIRST TRUST ADVISORS LP | 1,043,501 | 1,071,932 | +28,431 | 0.03 | 0.02 | -0.00 | buy |
| Qube Research & Technologies Ltd | 820,737 | 983,786 | +163,049 | 0.04 | 0.04 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,044,531 | 970,461 | -74,070 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 103,080 | 897,387 | +794,307 | 0.01 | 0.05 | +0.05 | buy |
| BAMCO INC /NY/ | 876,756 | 877,200 | +444 | 0.08 | 0.06 | -0.01 | buy |
| Assenagon Asset Management S.A. | 488,061 | 830,099 | +342,038 | 0.03 | 0.04 | +0.01 | buy |
| Nuveen, LLC | 1,113,072 | 829,598 | -283,474 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 526,586 | 788,977 | +262,391 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 740,631 | 780,940 | +40,309 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 848,613 | 755,316 | -93,297 | 0.01 | 0.01 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 769,350 | 726,490 | -42,860 | 1.14 | 0.85 | -0.28 | sell |
| Soleus Capital Management, L.P. | 0 | 715,439 | +715,439 | 0.00 | 1.34 | +1.34 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 684,782 | 684,782 | 0 | 0.40 | 0.32 | -0.08 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 667,329 | 676,838 | +9,509 | 0.03 | 0.02 | -0.00 | buy |
| Granite Investment Partners, LLC | 647,431 | 636,223 | -11,208 | 0.98 | 0.84 | -0.14 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 625,000 | +625,000 | 0.00 | 0.31 | +0.31 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 832,000 | 610,400 | -221,600 | 0.04 | 0.02 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 536,404 | 608,845 | +72,441 | 0.03 | 0.03 | -0.00 | buy |
| Legal & General Group Plc | 445,742 | 581,182 | +135,440 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 468,655 | 476,295 | +7,640 | 0.21 | 0.18 | -0.03 | buy |
| MACQUARIE GROUP LTD | 448,236 | 470,345 | +22,109 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 56,775 | 466,027 | +409,252 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 633,832 | 448,495 | -185,337 | 3.93 | 2.48 | -1.45 | sell |
| LOOMIS SAYLES & CO L P | 482,721 | 409,471 | -73,250 | 0.02 | 0.01 | -0.01 | sell |
| SEI INVESTMENTS CO | 292,714 | 359,837 | +67,123 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 195,793 | 343,969 | +148,176 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 93,867 | 336,978 | +243,111 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 490,846 | 325,524 | -165,322 | 0.01 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 299,190 | 320,563 | +21,373 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 352,589 | 310,466 | -42,123 | 0.00 | 0.00 | -0.00 | sell |
| AEGON ASSET MANAGEMENT UK PLC | 652,772 | 303,880 | -348,892 | 0.28 | 0.11 | -0.18 | sell |
| BARCLAYS PLC | 138,372 | 299,714 | +161,342 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 216,909 | 296,264 | +79,355 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 234,196 | 279,188 | +44,992 | 0.03 | 0.03 | -0.00 | buy |
| Casdin Capital, LLC | 276,308 | 276,308 | 0 | 0.67 | 0.68 | +0.01 | hold |
| PICTON MAHONEY ASSET MANAGEMENT | 260,495 | 267,205 | +6,710 | 0.26 | 0.10 | -0.16 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 262,912 | 266,074 | +3,162 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,000,359 | 265,873 | -734,486 | 0.02 | 0.00 | -0.02 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 476,216 | 242,774 | -233,442 | 1.26 | 0.51 | -0.75 | sell |
| Bank of New York Mellon Corp | 248,224 | 238,333 | -9,891 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 166,278 | 220,387 | +54,109 | 0.58 | 0.69 | +0.10 | buy |
| EFG Asset Management (North America) Corp. | 199,653 | 207,382 | +7,729 | 0.98 | 0.79 | -0.19 | buy |
| FRANKLIN RESOURCES INC | 216,656 | 206,204 | -10,452 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 213,074 | 205,328 | -7,746 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 0 | 181,923 | +181,923 | 0.00 | 0.01 | +0.01 | buy |
| Vestmark Advisory Solutions, Inc. | 96,205 | 177,212 | +81,007 | 0.07 | 0.07 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 175,959 | +175,959 | 0.00 | 0.06 | +0.06 | buy |
| Campbell & CO Investment Adviser LLC | 76,342 | 173,638 | +97,296 | 0.17 | 0.30 | +0.12 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 170,248 | +170,248 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 208,184 | 167,076 | -41,108 | 0.03 | 0.02 | -0.01 | sell |
| Palisades Investment Partners, LLC | 167,142 | 162,408 | -4,734 | 2.49 | 1.92 | -0.57 | sell |
| Magnetar Financial LLC | 21,969 | 159,188 | +137,219 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 156,396 | +156,396 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 122,327 | 153,013 | +30,686 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 150,200 | 148,900 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| QRG CAPITAL MANAGEMENT, INC. | 139,332 | 142,629 | +3,297 | 0.04 | 0.03 | -0.01 | buy |
| MARSHALL WACE, LLP | 8,331 | 128,657 | +120,326 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 115,458 | 128,293 | +12,835 | 0.20 | 0.19 | -0.01 | buy |
| Corient Private Wealth LLC | 127,839 | 127,899 | +60 | 0.01 | 0.00 | -0.00 | buy |
| Man Group plc | 84,167 | 126,571 | +42,404 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 97,786 | 124,581 | +26,795 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 118,624 | 120,012 | +1,388 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 120,454 | 119,549 | -905 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 91,994 | 115,041 | +23,047 | 0.05 | 0.04 | -0.01 | buy |
| Rafferty Asset Management, LLC | 110,969 | 108,822 | -2,147 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 8,869 | 107,673 | +98,804 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 189,708 | 106,786 | -82,922 | 0.01 | 0.01 | -0.01 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 198,592 | 106,510 | -92,082 | 0.01 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 92,020 | 94,187 | +2,167 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 79,310 | 87,524 | +8,214 | 0.00 | 0.00 | -0.00 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 86,550 | 81,950 | -4,600 | 2.71 | 2.23 | -0.48 | sell |
| CITIGROUP INC | 154,631 | 78,913 | -75,718 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 188,493 | 74,691 | -113,802 | 0.07 | 0.02 | -0.04 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 73,702 | +73,702 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 70,529 | 71,095 | +566 | 0.00 | 0.00 | -0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 30,604 | 70,494 | +39,890 | 0.11 | 0.17 | +0.06 | buy |
| State of New Jersey Common Pension Fund D | 49,149 | 68,739 | +19,590 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 74,300 | 68,438 | -5,862 | 0.00 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 69,010 | 66,233 | -2,777 | 0.02 | 0.02 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 71,994 | 65,785 | -6,209 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,803 | 64,734 | +6,931 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 35,663 | 56,747 | +21,084 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 195,889 | 55,167 | -140,722 | 0.01 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 54,106 | 54,336 | +230 | 0.02 | 0.02 | -0.00 | buy |
| FEDERATED HERMES, INC. | 94,423 | 54,167 | -40,256 | 0.01 | 0.00 | -0.00 | sell |