| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TUDOR INVESTMENT CORP ET AL | 20,000,000 | 21,750,000 | +1,750,000 | 0.12 | 0.10 | -0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 4,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 2,741,505 | 2,985,667 | +244,162 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 1,668,500 | 2,182,631 | +514,131 | 1.96 | 2.22 | +0.26 | buy |
| Artisan Partners Limited Partnership | 1,450,907 | 1,660,307 | +209,400 | 0.28 | 0.32 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,608,014 | 1,406,454 | -201,560 | 0.14 | 0.11 | -0.03 | sell |
| FMR LLC | 1,361,919 | 1,191,982 | -169,937 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,047,452 | 944,517 | -102,935 | 0.03 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 817,110 | 881,899 | +64,789 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 760,825 | 880,338 | +119,513 | 1.48 | 1.40 | -0.09 | buy |
| BNP Paribas Asset Management Holding S.A. | 762,062 | 866,528 | +104,466 | 0.10 | 0.10 | -0.00 | buy |
| STATE STREET CORP | 788,302 | 856,517 | +68,215 | 0.00 | 0.00 | -0.00 | buy |
| Holocene Advisors, LP | 1,248,658 | 783,636 | -465,022 | 0.36 | 0.21 | -0.14 | sell |
| JPMORGAN CHASE & CO | 714,896 | 766,216 | +51,320 | 0.01 | 0.01 | -0.00 | buy |
| Stephens Investment Management Group LLC | 561,530 | 693,437 | +131,907 | 0.91 | 0.88 | -0.02 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 674,698 | 685,496 | +10,798 | 0.27 | 0.22 | -0.05 | buy |
| BRAIDWELL LP | 610,192 | 654,262 | +44,070 | 2.40 | 2.88 | +0.48 | buy |
| D. E. Shaw & Co., Inc. | 554,266 | 629,686 | +75,420 | 0.05 | 0.05 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 390,577 | 561,251 | +170,674 | 0.04 | 0.05 | +0.01 | buy |
| BLAIR WILLIAM & CO/IL | 628,385 | 524,690 | -103,695 | 0.21 | 0.16 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 432,539 | 465,719 | +33,180 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 421,612 | 458,089 | +36,477 | 0.22 | 0.15 | -0.06 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 582,879 | 450,865 | -132,014 | 0.04 | 0.02 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 247,746 | 448,259 | +200,513 | 0.02 | 0.04 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 348,563 | 362,346 | +13,783 | 0.01 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 367,894 | 347,959 | -19,935 | 0.06 | 0.05 | -0.01 | sell |
| Capital Research Global Investors | 509,590 | 335,209 | -174,381 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 285,086 | 307,995 | +22,909 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 467,113 | 300,057 | -167,056 | 0.09 | 0.06 | -0.04 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 298,301 | +298,301 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 281,897 | 298,301 | +16,404 | 0.01 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 236,786 | 292,513 | +55,727 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 288,924 | +288,924 | 0.00 | 0.11 | +0.11 | buy |
| JANE STREET GROUP, LLC | 112,864 | 275,262 | +162,398 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 599,405 | 273,162 | -326,243 | 0.12 | 0.05 | -0.07 | sell |
| Qube Research & Technologies Ltd | 226,884 | 271,624 | +44,740 | 0.04 | 0.04 | -0.00 | buy |
| Rock Springs Capital Management LP | 261,750 | 269,650 | +7,900 | 1.82 | 1.57 | -0.26 | buy |
| SEI INVESTMENTS CO | 269,000 | 269,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 232,123 | 249,404 | +17,281 | 0.02 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 215,758 | 238,193 | +22,435 | 0.01 | 0.01 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 105,026 | 223,766 | +118,740 | 0.24 | 0.41 | +0.17 | buy |
| FRED ALGER MANAGEMENT, LLC | 280,040 | 220,789 | -59,251 | 0.15 | 0.09 | -0.06 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 156,004 | 202,004 | +46,000 | 0.54 | 0.50 | -0.05 | buy |
| Ophir Asset Management Pty Ltd | 335,807 | 201,491 | -134,316 | 4.62 | 1.97 | -2.64 | sell |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 188,345 | 191,798 | +3,453 | 0.01 | 0.01 | -0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 169,306 | 187,064 | +17,758 | 1.45 | 1.18 | -0.27 | buy |
| BAMCO INC /NY/ | 183,900 | 181,430 | -2,470 | 0.07 | 0.03 | -0.03 | sell |
| SEI INVESTMENTS CO | 198,904 | 178,765 | -20,139 | 0.02 | 0.02 | -0.00 | sell |
| First Light Asset Management, LLC | 168,116 | 167,092 | -1,024 | 1.78 | 1.21 | -0.57 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 166,637 | 165,998 | -639 | 0.01 | 0.01 | -0.00 | sell |
| Prosight Management, LP | 10,000 | 165,500 | +155,500 | 0.19 | 3.39 | +3.20 | buy |
| Schonfeld Strategic Advisors LLC | 88,133 | 152,062 | +63,929 | 0.08 | 0.10 | +0.01 | buy |
| NORGES BANK | 0 | 148,072 | +148,072 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 237,799 | 147,998 | -89,801 | 0.00 | 0.00 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 90,652 | 137,311 | +46,659 | 0.18 | 0.24 | +0.06 | buy |
| RAYMOND JAMES FINANCIAL INC | 145,123 | 135,265 | -9,858 | 0.01 | 0.00 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 68,454 | 132,475 | +64,021 | 0.08 | 0.15 | +0.06 | buy |
| Bank of New York Mellon Corp | 107,789 | 118,768 | +10,979 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 111,732 | 113,918 | +2,186 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 99,796 | 107,467 | +7,671 | 0.12 | 0.15 | +0.03 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 108,078 | 107,000 | -1,078 | 0.03 | 0.02 | -0.01 | sell |
| USS Investment Management Ltd | 0 | 106,957 | +106,957 | 0.00 | 0.05 | +0.05 | buy |
| Champlain Investment Partners, LLC | 0 | 97,015 | +97,015 | 0.00 | 0.30 | +0.30 | buy |
| Trexquant Investment LP | 111,311 | 96,268 | -15,043 | 0.10 | 0.07 | -0.02 | sell |
| CITADEL ADVISORS LLC | 113,600 | 95,931 | -17,669 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 149,459 | 95,871 | -53,588 | 0.03 | 0.02 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 102,594 | 92,993 | -9,601 | 0.02 | 0.01 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 0.44 | +0.44 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 90,460 | 88,257 | -2,203 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 61,681 | 85,830 | +24,149 | 0.05 | 0.07 | +0.01 | buy |
| Granahan Investment Management, LLC | 96,022 | 83,903 | -12,119 | 0.55 | 0.36 | -0.19 | sell |
| C WorldWide Group Holding A/S | 80,000 | 80,000 | 0 | 0.20 | 0.23 | +0.03 | hold |
| UBS Group AG | 91,903 | 77,665 | -14,238 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 65,875 | 75,724 | +9,849 | 0.29 | 0.29 | +0.00 | buy |
| Squarepoint Ops LLC | 6,164 | 71,862 | +65,698 | 0.00 | 0.02 | +0.02 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 70,000 | 69,000 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 137,040 | 67,924 | -69,116 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 40,125 | 67,267 | +27,142 | 0.49 | 0.82 | +0.33 | buy |
| Legal & General Group Plc | 51,569 | 65,304 | +13,735 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 65,196 | +65,196 | 0.00 | 0.67 | +0.67 | buy |
| Swiss National Bank | 63,700 | 64,800 | +1,100 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 1,840 | 63,343 | +61,503 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 53,476 | 59,733 | +6,257 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 49,575 | 56,534 | +6,959 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 34,565 | 55,987 | +21,422 | 0.04 | 0.05 | +0.01 | buy |
| Atle Fund Management AB | 22,322 | 54,102 | +31,780 | 2.02 | 1.73 | -0.29 | buy |
| Susquehanna Portfolio Strategies, LLC | 75,961 | 49,120 | -26,841 | 0.13 | 0.09 | -0.04 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 58,800 | 48,700 | -10,100 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 26,898 | 47,903 | +21,005 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,050 | 44,699 | -3,351 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,687 | 44,239 | +8,552 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,324 | 44,067 | +6,743 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 88,210 | 43,362 | -44,848 | 0.02 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 36,299 | 42,595 | +6,296 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 42,346 | 42,314 | -32 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 39,422 | 42,028 | +2,606 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 53,800 | 38,500 | -15,300 | 0.01 | 0.01 | -0.00 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 34,744 | 34,455 | -289 | 0.50 | 0.50 | +0.00 | sell |
| Engineers Gate Manager LP | 49,269 | 30,418 | -18,851 | 0.07 | 0.05 | -0.03 | sell |