| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 7,148,936 | +7,148,936 | 0.00 | 0.76 | +0.76 | buy |
| SUMMER ROAD LLC | 7,660,550 | 14,360,633 | +6,700,083 | 100.00 | 100.00 | 0.00 | buy |
| TCG Crossover Management, LLC | 0 | 5,319,148 | +5,319,148 | 0.00 | 3.83 | +3.83 | buy |
| VR Adviser, LLC | 7,775,760 | 12,762,462 | +4,986,702 | 2.38 | 5.52 | +3.15 | buy |
| Deep Track Capital, LP | 9,230,769 | 12,721,460 | +3,490,691 | 1.44 | 3.33 | +1.89 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 3,324,468 | +3,324,468 | 0.00 | 0.53 | +0.53 | buy |
| Octagon Capital Advisors LP | 0 | 2,425,000 | +2,425,000 | 0.00 | 2.68 | +2.68 | buy |
| VANGUARD GROUP INC | 5,118,102 | 7,235,131 | +2,117,029 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,536,009 | 5,420,601 | +1,884,592 | 0.02 | 0.05 | +0.03 | buy |
| Logos Global Management LP | 4,000,000 | 5,811,436 | +1,811,436 | 1.98 | 5.47 | +3.49 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 1,310,000 | 2,635,287 | +1,325,287 | 3.29 | 15.58 | +12.29 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 1,086,794 | +1,086,794 | 0.00 | 0.04 | +0.04 | buy |
| MORGAN STANLEY | 323,155 | 1,373,035 | +1,049,880 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 700,000 | 1,728,723 | +1,028,723 | 0.53 | 2.45 | +1.92 | buy |
| STATE STREET CORP | 1,539,575 | 2,402,380 | +862,805 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 34,639 | 797,528 | +762,889 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,736,814 | 2,486,043 | +749,229 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 53,344 | 662,672 | +609,328 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 6,070,000 | 6,653,138 | +583,138 | 7.20 | 13.19 | +6.00 | buy |
| Invesco Ltd. | 221,027 | 772,366 | +551,339 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 90,833 | 483,506 | +392,673 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 375,000 | +375,000 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 336,132 | +336,132 | 0.00 | 0.03 | +0.03 | buy |
| GROUP ONE TRADING LLC | 44,399 | 373,303 | +328,904 | 0.01 | 0.12 | +0.11 | buy |
| NORTHERN TRUST CORP | 671,984 | 970,098 | +298,114 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 440,000 | 724,685 | +284,685 | 0.78 | 1.62 | +0.84 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 270,918 | +270,918 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 110,106 | 361,093 | +250,987 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 193,600 | +193,600 | 0.00 | 1.51 | +1.51 | buy |
| GOLDMAN SACHS GROUP INC | 87,553 | 269,181 | +181,628 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 39,170 | 185,308 | +146,138 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 86,989 | 227,053 | +140,064 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 131,105 | 252,356 | +121,251 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 115,000 | +115,000 | 0.00 | 0.56 | +0.56 | buy |
| CITIGROUP INC | 19,177 | 118,305 | +99,128 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,202 | 313,036 | +91,834 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 243,361 | 331,252 | +87,891 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,647 | 195,517 | +87,870 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 82,058 | +82,058 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 80,400 | +80,400 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 62,054 | +62,054 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 55,200 | +55,200 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 53,456 | +53,456 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 676,400 | 725,990 | +49,590 | 0.02 | 0.02 | -0.01 | buy |
| Quantbot Technologies LP | 0 | 46,500 | +46,500 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 44,300 | +44,300 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 0 | 43,319 | +43,319 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,737 | 72,440 | +40,703 | 0.00 | 0.00 | +0.00 | buy |
| Semanteon Capital Management, LP | 0 | 39,122 | +39,122 | 0.00 | 0.23 | +0.23 | buy |
| Balboa Wealth Partners | 0 | 38,000 | +38,000 | 0.00 | 0.11 | +0.11 | buy |
| RHUMBLINE ADVISERS | 113,965 | 151,956 | +37,991 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 29,700 | +29,700 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 28,987 | +28,987 | 0.00 | 0.01 | +0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 26,976 | +26,976 | 0.00 | 0.04 | +0.04 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 23,039 | +23,039 | 0.00 | 0.02 | +0.02 | buy |
| Man Group plc | 0 | 21,543 | +21,543 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 20,523 | +20,523 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 20,394 | +20,394 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 40,648 | 59,333 | +18,685 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 39,730 | 56,981 | +17,251 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 15,312 | +15,312 | 0.00 | 0.12 | +0.12 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 15,005 | +15,005 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,425 | 46,348 | +14,923 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,203 | 36,039 | +13,836 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 18,987 | 31,852 | +12,865 | 0.00 | 0.01 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 12,537 | +12,537 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 12,381 | +12,381 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,192 | 21,199 | +12,007 | 0.01 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 0 | 11,868 | +11,868 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 94,350 | 104,950 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 10,304 | +10,304 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 18,304 | 28,498 | +10,194 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 19,646 | 28,946 | +9,300 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 8,040 | +8,040 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 21,959 | 27,880 | +5,921 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 370,372 | 376,200 | +5,828 | 0.33 | 0.68 | +0.35 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,250 | 36,956 | +4,706 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,735 | +3,735 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,473 | 12,114 | +3,641 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 13,944 | 17,297 | +3,353 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,274 | 11,531 | +3,257 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 29,000 | 31,736 | +2,736 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 2,600 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,135 | 12,708 | +2,573 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,536 | +2,536 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 4,201 | 6,106 | +1,905 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 16,138 | 17,768 | +1,630 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 68,025 | 69,226 | +1,201 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 638,126 | 638,305 | +179 | 0.01 | 0.02 | +0.01 | buy |
| SJS Investment Consulting Inc. | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 262 | 407 | +145 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,190 | 2,323 | +133 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 250 | 371 | +121 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 20,768 | 20,768 | 0 | 0.00 | 0.01 | +0.00 | hold |
| TRUST CO OF VERMONT | 6,000 | 6,000 | 0 | 0.00 | 0.00 | +0.00 | hold |