| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 31,785,605 | 32,653,764 | +868,159 | 0.02 | 0.01 | -0.01 | buy |
| Deep Track Capital, LP | 8,070,414 | 19,686,282 | +11,615,868 | 2.23 | 3.44 | +1.21 | buy |
| BlackRock, Inc. | 15,602,394 | 16,132,931 | +530,537 | 0.00 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 10,777,777 | 12,315,000 | +1,537,223 | 1.29 | 1.03 | -0.26 | buy |
| SUMMER ROAD LLC | 11,108,555 | 11,879,825 | +771,270 | 97.92 | 70.84 | -27.08 | buy |
| VR Adviser, LLC | 7,315,547 | 10,346,926 | +3,031,379 | 4.39 | 3.27 | -1.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 171,524 | 5,897,149 | +5,725,625 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 1,016,248 | 5,534,985 | +4,518,737 | 0.02 | 0.08 | +0.06 | buy |
| STATE STREET CORP | 4,196,330 | 4,708,419 | +512,089 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,356,547 | 4,529,185 | +172,638 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 4,341,951 | 4,129,687 | -212,264 | 0.02 | 0.02 | -0.00 | sell |
| Logos Global Management LP | 3,500,000 | 3,850,000 | +350,000 | 2.83 | 1.68 | -1.15 | buy |
| Octagon Capital Advisors LP | 2,623,600 | 3,166,600 | +543,000 | 3.99 | 2.97 | -1.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 763,559 | 2,692,622 | +1,929,063 | 0.02 | 0.04 | +0.03 | buy |
| Commodore Capital LP | 0 | 2,575,000 | +2,575,000 | 0.00 | 1.26 | +1.26 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,487,934 | 2,340,620 | -147,314 | 5.00 | 3.64 | -1.37 | sell |
| TWO SIGMA INVESTMENTS, LP | 380,713 | 1,830,159 | +1,449,446 | 0.01 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 1,666,136 | 1,667,609 | +1,473 | 0.08 | 0.05 | -0.02 | buy |
| TCG Crossover Management, LLC | 5,740,231 | 1,647,752 | -4,092,479 | 2.31 | 0.40 | -1.91 | sell |
| Invesco Ltd. | 895,687 | 1,536,779 | +641,092 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,462,503 | 1,525,626 | +63,123 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,244,944 | 1,520,631 | +275,687 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,460,457 | 1,461,177 | +720 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 879,144 | 1,280,119 | +400,975 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 791,200 | 1,147,982 | +356,782 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,547,523 | 1,110,366 | -437,157 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 440,437 | 980,757 | +540,320 | 0.01 | 0.02 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 968,597 | +968,597 | 0.00 | 1.18 | +1.18 | buy |
| Candriam S.C.A. | 841,602 | 949,216 | +107,614 | 0.05 | 0.04 | -0.01 | buy |
| Artisan Partners Limited Partnership | 1,063,371 | 902,931 | -160,440 | 0.02 | 0.01 | -0.01 | sell |
| Empire Life Investments Inc. | 540,115 | 884,297 | +344,182 | 0.37 | 0.45 | +0.08 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 883,621 | +883,621 | 0.00 | 0.44 | +0.44 | buy |
| RAYMOND JAMES FINANCIAL INC | 842,187 | 859,485 | +17,298 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 1,034,229 | 804,589 | -229,640 | 0.01 | 0.01 | -0.01 | sell |
| Cetera Investment Advisers | 722,540 | 764,615 | +42,075 | 0.01 | 0.01 | -0.00 | buy |
| Walleye Capital LLC | 230,509 | 741,142 | +510,633 | 0.02 | 0.04 | +0.02 | buy |
| MARSHALL WACE, LLP | 1,377,203 | 740,803 | -636,400 | 0.02 | 0.01 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 571,103 | 720,462 | +149,359 | 0.21 | 0.23 | +0.01 | buy |
| HRT FINANCIAL LP | 402,963 | 709,218 | +306,255 | 0.02 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 649,756 | +649,756 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,475,849 | 635,922 | -1,839,927 | 0.02 | 0.00 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 590,721 | 631,741 | +41,020 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 494,792 | 614,378 | +119,586 | 0.03 | 0.03 | -0.00 | buy |
| Knoll Capital Management, LLC | 600,400 | 600,400 | 0 | 3.34 | 2.82 | -0.52 | hold |
| Opaleye Management Inc. | 1,595,000 | 600,000 | -995,000 | 2.55 | 0.67 | -1.89 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 1,052,995 | 592,108 | -460,887 | 8.68 | 3.57 | -5.11 | sell |
| Aberdeen Group plc | 0 | 558,380 | +558,380 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 127,410 | 538,939 | +411,529 | 0.02 | 0.07 | +0.04 | buy |
| Qube Research & Technologies Ltd | 769,774 | 531,816 | -237,958 | 0.01 | 0.01 | -0.01 | sell |
| Aptus Capital Advisors, LLC | 500,752 | 529,779 | +29,027 | 0.05 | 0.04 | -0.01 | buy |
| Second Line Capital, LLC | 500,746 | 528,290 | +27,544 | 1.25 | 0.94 | -0.31 | buy |
| Verition Fund Management LLC | 171,606 | 527,338 | +355,732 | 0.01 | 0.04 | +0.03 | buy |
| JPMORGAN CHASE & CO | 550,269 | 520,663 | -29,606 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 180,723 | 499,339 | +318,616 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 490,278 | 475,987 | -14,291 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 293,263 | 470,029 | +176,766 | 0.01 | 0.02 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 445,405 | 441,775 | -3,630 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 344,067 | 441,573 | +97,506 | 1.08 | 1.03 | -0.04 | buy |
| BEACON INVESTMENT ADVISORS LLC | 165,556 | 430,876 | +265,320 | 0.81 | 1.38 | +0.57 | buy |
| Nuveen, LLC | 462,807 | 411,080 | -51,727 | 0.00 | 0.00 | -0.00 | sell |
| Principia Wealth Advisory, LLC | 0 | 408,700 | +408,700 | 0.00 | 1.96 | +1.96 | buy |
| Jump Financial, LLC | 173,793 | 401,833 | +228,040 | 0.03 | 0.05 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 601,360 | 397,092 | -204,268 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 49,073 | 395,184 | +346,111 | 0.02 | 0.06 | +0.04 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 385,825 | 392,718 | +6,893 | 0.71 | 0.53 | -0.19 | buy |
| Rock Springs Capital Management LP | 345,820 | 383,716 | +37,896 | 0.22 | 0.19 | -0.02 | buy |
| Caption Management, LLC | 0 | 382,759 | +382,759 | 0.00 | 0.15 | +0.15 | buy |
| Propel Bio Management, LLC | 0 | 382,375 | +382,375 | 0.00 | 2.03 | +2.03 | buy |
| Pictet Asset Management Holding SA | 27,272 | 362,596 | +335,324 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.39 | +0.39 | buy |
| Birchview Capital, LP | 0 | 320,000 | +320,000 | 0.00 | 1.54 | +1.54 | buy |
| Swiss National Bank | 313,300 | 313,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 307,747 | 308,906 | +1,159 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 268,694 | 308,321 | +39,627 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 265,000 | 305,000 | +40,000 | 0.30 | 0.32 | +0.02 | buy |
| E. Ohman J:or Asset Management AB | 0 | 300,000 | +300,000 | 0.00 | 0.07 | +0.07 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 294,628 | +294,628 | 0.00 | 0.24 | +0.24 | buy |
| SEI INVESTMENTS CO | 169,673 | 258,164 | +88,491 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 238,000 | +238,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 241,321 | 231,101 | -10,220 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 92,648 | 227,808 | +135,160 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,153,910 | 218,478 | -935,432 | 0.01 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 150,701 | 213,706 | +63,005 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 188,775 | +188,775 | 0.00 | 0.59 | +0.59 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 59,300 | 188,368 | +129,068 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 46,089 | 177,468 | +131,379 | 0.00 | 0.00 | +0.00 | buy |
| RoundAngle Advisors LLC | 168,854 | 166,484 | -2,370 | 1.49 | 1.05 | -0.44 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 18,139 | 165,984 | +147,845 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 94,426 | 152,884 | +58,458 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 150,744 | +150,744 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 857,649 | 148,977 | -708,672 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 0 | 138,897 | +138,897 | 0.00 | 0.02 | +0.02 | buy |
| Vontobel Holding Ltd. | 0 | 135,605 | +135,605 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 132,632 | +132,632 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 157,336 | 131,162 | -26,174 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 0 | 125,000 | +125,000 | 0.00 | 0.28 | +0.28 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 124,672 | 124,672 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legato Capital Management LLC | 123,649 | 121,951 | -1,698 | 0.13 | 0.09 | -0.04 | sell |
| TRUIST FINANCIAL CORP | 100,000 | 121,000 | +21,000 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 255,222 | 112,766 | -142,456 | 0.00 | 0.00 | -0.00 | sell |