| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 3,695,047 | +3,320,047 | 0.01 | 0.05 | +0.04 | buy |
| Avoro Capital Advisors LLC | 7,148,936 | 8,060,000 | +911,064 | 0.76 | 0.73 | -0.02 | buy |
| SUMMER ROAD LLC | 14,360,633 | 14,885,633 | +525,000 | 100.00 | 98.54 | -1.46 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,364,084 | 2,590,265 | +226,181 | 4.24 | 3.39 | -0.85 | buy |
| Banco Santander, S.A. | 208,196 | 377,368 | +169,172 | 0.02 | 0.03 | +0.01 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 140,000 | 300,000 | +160,000 | 0.06 | 0.09 | +0.03 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 2,635,287 | 2,771,130 | +135,843 | 15.58 | 15.96 | +0.39 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 376,200 | 442,509 | +66,309 | 0.68 | 0.57 | -0.11 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 188,578 | 238,659 | +50,081 | 0.12 | 0.10 | 0.00 | buy |
| TRUST CO OF VERMONT | 6,000 | 6,200 | +200 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,199 | 18,196 | -3,003 | 0.02 | 0.02 | -0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 20,394 | 12,383 | -8,011 | 0.03 | 0.02 | -0.02 | sell |
| Artia Global Partners LP | 724,685 | 500,000 | -224,685 | 1.62 | 0.88 | -0.74 | sell |
| Logos Global Management LP | 5,811,436 | 5,150,000 | -661,436 | 5.47 | 4.06 | -1.41 | sell |
| Opaleye Management Inc. | 6,653,138 | 5,307,500 | -1,345,638 | 13.19 | 8.29 | -4.90 | sell |