| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUMMER ROAD LLC | 14,360,633 | 14,885,633 | +525,000 | 100.00 | 98.54 | -1.46 | buy |
| VR Adviser, LLC | 12,762,462 | 12,762,462 | 0 | 5.52 | 5.56 | +0.03 | hold |
| Deep Track Capital, LP | 12,721,460 | 12,721,460 | 0 | 3.33 | 2.60 | -0.73 | hold |
| VANGUARD GROUP INC | 7,235,131 | 8,612,101 | +1,376,970 | 0.00 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 7,148,936 | 8,060,000 | +911,064 | 0.76 | 0.73 | -0.02 | buy |
| TCG Crossover Management, LLC | 5,319,148 | 5,319,148 | 0 | 3.83 | 3.79 | -0.03 | hold |
| Opaleye Management Inc. | 6,653,138 | 5,307,500 | -1,345,638 | 13.19 | 8.29 | -4.90 | sell |
| Logos Global Management LP | 5,811,436 | 5,150,000 | -661,436 | 5.47 | 4.06 | -1.41 | sell |
| CITADEL ADVISORS LLC | 5,420,601 | 4,053,862 | -1,366,739 | 0.05 | 0.03 | -0.02 | sell |
| STATE STREET CORP | 2,402,380 | 3,920,663 | +1,518,283 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 3,695,047 | +3,320,047 | 0.01 | 0.05 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,486,043 | 3,452,087 | +966,044 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,324,468 | 3,324,468 | 0 | 0.53 | 0.55 | +0.02 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 2,635,287 | 2,771,130 | +135,843 | 15.58 | 15.98 | +0.40 | buy |
| Point72 Asset Management, L.P. | 0 | 2,706,663 | +2,706,663 | 0.00 | 0.06 | +0.06 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,364,084 | 2,590,265 | +226,181 | 4.24 | 3.39 | -0.85 | buy |
| Octagon Capital Advisors LP | 2,425,000 | 2,425,000 | 0 | 2.68 | 2.74 | +0.05 | hold |
| BRAIDWELL LP | 0 | 1,643,770 | +1,643,770 | 0.00 | 0.35 | +0.35 | buy |
| FRANKLIN RESOURCES INC | 2,168,313 | 1,170,163 | -998,150 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,373,035 | 1,162,481 | -210,554 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 662,672 | 1,110,454 | +447,782 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 970,098 | 1,079,277 | +109,179 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 227,053 | 1,036,171 | +809,118 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.69 | +0.69 | buy |
| DEUTSCHE BANK AG\ | 797,528 | 807,310 | +9,782 | 0.00 | 0.00 | -0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 750,000 | +750,000 | 0.00 | 4.06 | +4.06 | buy |
| UBS Group AG | 483,506 | 748,733 | +265,227 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 725,990 | 739,044 | +13,054 | 0.02 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,086,794 | 689,017 | -397,777 | 0.04 | 0.02 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 269,181 | 679,417 | +410,236 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 638,305 | 638,665 | +360 | 0.02 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,413 | 536,119 | +516,706 | 0.00 | 0.01 | +0.01 | buy |
| Tri Locum Partners LP | 0 | 514,642 | +514,642 | 0.00 | 0.89 | +0.89 | buy |
| Artia Global Partners LP | 724,685 | 500,000 | -224,685 | 1.62 | 0.88 | -0.74 | sell |
| Bank of New York Mellon Corp | 331,252 | 495,635 | +164,383 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,036 | 450,380 | +137,344 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 376,200 | 442,509 | +66,309 | 0.68 | 0.57 | -0.11 | buy |
| MARSHALL WACE, LLP | 0 | 429,592 | +429,592 | 0.00 | 0.00 | +0.00 | buy |
| Banco Santander, S.A. | 208,196 | 377,368 | +169,172 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 361,093 | 373,081 | +11,988 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 270,918 | 314,554 | +43,636 | 0.00 | 0.00 | -0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 140,000 | 300,000 | +160,000 | 0.06 | 0.09 | +0.03 | buy |
| Aptus Capital Advisors, LLC | 0 | 262,810 | +262,810 | 0.00 | 0.03 | +0.03 | buy |
| Second Line Capital, LLC | 0 | 262,810 | +262,810 | 0.00 | 0.55 | +0.55 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,200 | 241,948 | +186,748 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 188,578 | 238,659 | +50,081 | 0.05 | 0.05 | -0.00 | buy |
| Erste Asset Management GmbH | 235,800 | 235,800 | 0 | 0.03 | 0.02 | -0.01 | hold |
| RHUMBLINE ADVISERS | 151,956 | 211,301 | +59,345 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 200,400 | 200,400 | 0 | 1.13 | 0.92 | -0.21 | hold |
| Swiss National Bank | 0 | 197,900 | +197,900 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 252,356 | 194,012 | -58,344 | 0.00 | 0.00 | -0.00 | sell |
| NOTTINGHAM ADVISORS, INC. | 193,266 | 193,266 | 0 | 0.22 | 0.16 | -0.06 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 186,060 | +186,060 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 104,950 | 162,820 | +57,870 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 149,515 | 149,515 | 0 | 0.16 | 0.14 | -0.03 | hold |
| Jump Financial, LLC | 43,319 | 123,442 | +80,123 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,440 | 116,964 | +44,524 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 80,400 | 112,800 | +32,400 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,645 | 102,079 | +90,434 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 12,114 | 98,675 | +86,561 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 59,333 | 90,280 | +30,947 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 90,000 | 90,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 36,956 | 88,051 | +51,095 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 69,226 | 85,373 | +16,147 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,517 | 78,868 | -116,649 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 67,651 | +67,651 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 17,297 | 64,911 | +47,614 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 118,305 | 64,310 | -53,995 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 46,348 | 63,975 | +17,627 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 61,859 | +61,859 | 0.00 | 0.15 | +0.15 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 185,308 | 55,314 | -129,994 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 53,500 | +53,500 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,039 | 51,319 | +15,280 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 772,366 | 45,900 | -726,466 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 11,868 | 43,182 | +31,314 | 0.00 | 0.01 | +0.01 | buy |
| Alpine Global Management, LLC | 0 | 41,165 | +41,165 | 0.00 | 0.05 | +0.05 | buy |
| GROUP ONE TRADING LLC | 373,303 | 40,725 | -332,578 | 0.12 | 0.01 | -0.11 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 37,300 | +37,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 31,736 | 36,543 | +4,807 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 35,720 | +35,720 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 32,900 | +32,900 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,735 | 32,044 | +28,309 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 31,278 | 31,418 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Triumph Capital Management | 0 | 30,761 | +30,761 | 0.00 | 0.08 | +0.08 | buy |
| Simplicity Wealth,LLC | 28,987 | 28,987 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Arizona State Retirement System | 0 | 28,151 | +28,151 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 27,880 | 26,364 | -1,516 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 28,498 | 25,049 | -3,449 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 33,841 | 22,942 | -10,899 | 0.01 | 0.01 | -0.00 | sell |
| Caption Management, LLC | 0 | 22,900 | +22,900 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 22,088 | +22,088 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 20,768 | 20,768 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EntryPoint Capital, LLC | 15,312 | 20,597 | +5,285 | 0.12 | 0.07 | -0.06 | buy |
| China Universal Asset Management Co., Ltd. | 21,199 | 18,196 | -3,003 | 0.02 | 0.02 | -0.01 | sell |
| HighTower Advisors, LLC | 17,768 | 17,768 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IEQ CAPITAL, LLC | 30,129 | 17,629 | -12,500 | 0.00 | 0.00 | -0.00 | sell |
| Relyea Zuckerberg Hanson LLC | 17,600 | 17,600 | 0 | 0.03 | 0.02 | -0.01 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 12,708 | 17,403 | +4,695 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 17,167 | +17,167 | 0.00 | 0.00 | +0.00 | buy |