| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 941,294 | 19,608,171 | +18,666,877 | 0.00 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 14,294,420 | 14,294,420 | 0 | 3.39 | 4.26 | +0.87 | hold |
| SUMMER ROAD LLC | 13,878,018 | 13,887,468 | +9,450 | 98.23 | 98.23 | -0.00 | buy |
| VR Adviser, LLC | 12,762,462 | 12,762,462 | 0 | 7.96 | 8.88 | +0.92 | hold |
| BlackRock, Inc. | 12,012,397 | 10,546,379 | -1,466,018 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 8,364,515 | 8,392,175 | +27,660 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 8,060,000 | 7,400,000 | -660,000 | 0.92 | 1.20 | +0.28 | sell |
| TCG Crossover Management, LLC | 5,319,148 | 5,319,148 | 0 | 5.32 | 5.64 | +0.32 | hold |
| CITADEL ADVISORS LLC | 4,811,108 | 4,886,014 | +74,906 | 0.03 | 0.04 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,200,000 | 3,890,177 | -1,309,823 | 0.07 | 0.06 | -0.01 | sell |
| STATE STREET CORP | 3,391,850 | 3,509,110 | +117,260 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,314,018 | 3,420,340 | +2,106,322 | 0.44 | 1.36 | +0.91 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,422,412 | 3,284,171 | -138,241 | 0.00 | 0.00 | +0.00 | sell |
| DELTEC ASSET MANAGEMENT LLC | 2,716,373 | 2,794,892 | +78,519 | 4.28 | 4.62 | +0.35 | buy |
| MORGAN STANLEY | 2,188,478 | 2,571,723 | +383,245 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 296,000 | 2,425,000 | +2,129,000 | 1.58 | 4.94 | +3.36 | buy |
| Logos Global Management LP | 2,300,000 | 2,200,000 | -100,000 | 3.00 | 2.73 | -0.27 | sell |
| UBS Group AG | 1,334,939 | 1,965,151 | +630,212 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,942,362 | 1,904,214 | -38,148 | 0.04 | 0.04 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 439,444 | 1,788,603 | +1,349,159 | 0.01 | 0.03 | +0.02 | buy |
| Opaleye Management Inc. | 1,595,000 | 1,595,000 | 0 | 2.60 | 3.00 | +0.39 | hold |
| Invesco Ltd. | 804,829 | 1,538,846 | +734,017 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 1,218,700 | 1,218,700 | 0 | 4.35 | 5.47 | +1.12 | hold |
| FRANKLIN RESOURCES INC | 1,170,259 | 1,170,163 | -96 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,290,917 | 1,156,258 | -134,659 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,112,793 | 1,095,455 | -17,338 | 0.00 | 0.00 | +0.00 | sell |
| Artisan Partners Limited Partnership | 1,155,076 | 1,065,969 | -89,107 | 0.01 | 0.01 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 1,219,724 | 1,014,940 | -204,784 | 10.37 | 13.15 | +2.78 | sell |
| RAYMOND JAMES FINANCIAL INC | 364,243 | 884,381 | +520,138 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 847,468 | 861,962 | +14,494 | 0.21 | 0.24 | +0.03 | buy |
| Patient Square Capital LP | 920,199 | 817,699 | -102,500 | 2.79 | 2.74 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 942,288 | 759,260 | -183,028 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 750,950 | 750,950 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Saturn V Capital Management LP | 598,191 | 728,576 | +130,385 | 2.21 | 2.74 | +0.53 | buy |
| JPMORGAN CHASE & CO | 337,831 | 712,100 | +374,269 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 721,364 | 705,406 | -15,958 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 582,009 | 605,165 | +23,156 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 600,400 | 600,400 | 0 | 2.86 | 1.32 | -1.54 | hold |
| Pale Fire Capital SE | 439,387 | 530,135 | +90,748 | 0.39 | 0.51 | +0.13 | buy |
| AXA S.A. | 559,519 | 516,500 | -43,019 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 452,964 | 503,987 | +51,023 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 495,236 | 496,030 | +794 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 454,000 | 410,048 | -43,952 | 0.01 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 391,754 | +391,754 | 0.00 | 0.00 | +0.00 | buy |
| Aptus Capital Advisors, LLC | 346,098 | 385,467 | +39,369 | 0.03 | 0.04 | +0.01 | buy |
| Second Line Capital, LLC | 346,098 | 385,467 | +39,369 | 0.65 | 0.83 | +0.18 | buy |
| Bank of New York Mellon Corp | 419,493 | 382,309 | -37,184 | 0.00 | 0.00 | +0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 384,325 | 381,595 | -2,730 | 0.59 | 0.64 | +0.06 | sell |
| Nuveen, LLC | 414,104 | 362,310 | -51,794 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 212,952 | 316,276 | +103,324 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 222,004 | 296,546 | +74,542 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 336,516 | 291,570 | -44,946 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 244,984 | 242,039 | -2,945 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 258,225 | 240,021 | -18,204 | 0.00 | 0.00 | +0.00 | sell |
| Erste Asset Management GmbH | 235,800 | 235,800 | 0 | 0.02 | 0.02 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 68,145 | 232,886 | +164,741 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 223,115 | 225,548 | +2,433 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 75,869 | 218,293 | +142,424 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 258,363 | 210,205 | -48,158 | 0.05 | 0.05 | +0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 54,483 | 208,530 | +154,047 | 0.00 | 0.00 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 207,765 | +207,765 | 0.00 | 0.05 | +0.05 | buy |
| Swiss National Bank | 184,000 | 197,400 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 341,800 | 193,700 | -148,100 | 0.00 | 0.00 | -0.00 | sell |
| Weiss Asset Management LP | 0 | 187,615 | +187,615 | 0.00 | 0.03 | +0.03 | buy |
| RoundAngle Advisors LLC | 195,875 | 185,706 | -10,169 | 1.32 | 1.44 | +0.12 | sell |
| Banco Santander, S.A. | 184,048 | 184,048 | 0 | 0.01 | 0.02 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 162,820 | 162,820 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 161,903 | +161,903 | 0.00 | 0.06 | +0.06 | buy |
| COURIER CAPITAL LLC | 154,266 | 154,266 | 0 | 0.07 | 0.09 | +0.01 | hold |
| SEI INVESTMENTS CO | 144,349 | 153,670 | +9,321 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 70,430 | 148,602 | +78,172 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 199,030 | 126,681 | -72,349 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 125,741 | 126,366 | +625 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 119,146 | +119,146 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 113,090 | 112,820 | -270 | 0.11 | 0.12 | +0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 15,650 | 111,022 | +95,372 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 461,230 | 110,832 | -350,398 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 105,049 | 110,472 | +5,423 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 104,403 | 104,853 | +450 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 60,123 | 102,833 | +42,710 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRUIST FINANCIAL CORP | 50,000 | 100,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 131,987 | 99,844 | -32,143 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 98,097 | 98,097 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 113,597 | 91,236 | -22,361 | 0.01 | 0.01 | -0.00 | sell |
| BROWN ADVISORY INC | 90,000 | 90,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 91,998 | 89,383 | -2,615 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 42,297 | 88,980 | +46,683 | 0.37 | 1.03 | +0.66 | buy |
| HighVista Strategies LLC | 85,241 | 88,876 | +3,635 | 0.24 | 0.30 | +0.06 | buy |
| MetLife Investment Management, LLC | 93,397 | 84,066 | -9,331 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 93,619 | 77,034 | -16,585 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 77,045 | 74,150 | -2,895 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,304 | 72,618 | +1,314 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 67,530 | +67,530 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 31,535 | 61,995 | +30,460 | 0.02 | 0.05 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 49,962 | 61,578 | +11,616 | 0.01 | 0.02 | +0.00 | buy |
| Allianz Asset Management GmbH | 37,500 | 61,200 | +23,700 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 54,090 | +54,090 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 53,500 | 53,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Simplicity Wealth,LLC | 27,987 | 40,332 | +12,345 | 0.02 | 0.02 | -0.00 | buy |