| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 32,653,764 | 32,844,043 | +190,279 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 19,686,282 | 19,686,282 | 0 | 3.44 | 2.85 | -0.59 | hold |
| BlackRock, Inc. | 16,132,931 | 19,376,555 | +3,243,624 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 12,315,000 | 12,540,000 | +225,000 | 1.03 | 1.11 | +0.08 | buy |
| SUMMER ROAD LLC | 11,879,825 | 12,208,296 | +328,471 | 70.84 | 74.46 | +3.61 | buy |
| VR Adviser, LLC | 10,346,926 | 10,346,926 | 0 | 3.27 | 3.08 | -0.19 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,897,149 | 7,623,533 | +1,726,384 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 3,850,000 | 5,300,000 | +1,450,000 | 1.68 | 2.24 | +0.56 | buy |
| STATE STREET CORP | 4,708,419 | 5,233,282 | +524,863 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,529,185 | 5,021,092 | +491,907 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,534,985 | 3,292,193 | -2,242,792 | 0.08 | 0.05 | -0.03 | sell |
| DIMENSIONAL FUND ADVISORS LP | 649,756 | 2,783,367 | +2,133,611 | 0.00 | 0.00 | +0.00 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,340,620 | 2,476,197 | +135,577 | 3.64 | 3.59 | -0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,692,622 | 2,270,707 | -421,915 | 0.04 | 0.04 | -0.00 | sell |
| Octagon Capital Advisors LP | 3,166,600 | 2,075,000 | -1,091,600 | 2.97 | 1.87 | -1.10 | sell |
| NORTHERN TRUST CORP | 1,525,626 | 1,799,426 | +273,800 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,110,366 | 1,761,754 | +651,388 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 411,080 | 1,697,274 | +1,286,194 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,667,609 | 1,667,609 | 0 | 0.05 | 0.05 | -0.00 | hold |
| TCG Crossover Management, LLC | 1,647,752 | 1,647,752 | 0 | 0.40 | 0.39 | -0.01 | hold |
| UBS Group AG | 1,520,631 | 1,551,001 | +30,370 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,550,000 | +1,550,000 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,533,438 | +1,533,438 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,461,177 | 1,533,438 | +72,261 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 980,757 | 1,415,913 | +435,156 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 1,536,779 | 1,344,391 | -192,388 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 350,000 | 1,300,000 | +950,000 | 0.39 | 0.96 | +0.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,830,159 | 1,218,513 | -611,646 | 0.01 | 0.01 | -0.00 | sell |
| Knoll Capital Management, LLC | 600,400 | 1,150,400 | +550,000 | 2.82 | 6.30 | +3.48 | buy |
| HRT FINANCIAL LP | 709,218 | 1,077,090 | +367,872 | 0.01 | 0.02 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 859,485 | 963,316 | +103,831 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 499,339 | 950,338 | +450,999 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,280,119 | 911,831 | -368,288 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 949,216 | 907,839 | -41,377 | 0.04 | 0.04 | -0.00 | sell |
| Empire Life Investments Inc. | 884,297 | 871,692 | -12,605 | 0.45 | 0.48 | +0.03 | sell |
| Cetera Investment Advisers | 764,615 | 785,732 | +21,117 | 0.01 | 0.01 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 720,462 | 753,495 | +33,033 | 0.23 | 0.24 | +0.01 | buy |
| Aptus Capital Advisors, LLC | 529,779 | 638,691 | +108,912 | 0.04 | 0.05 | +0.01 | buy |
| Second Line Capital, LLC | 528,290 | 638,640 | +110,350 | 0.94 | 1.17 | +0.23 | buy |
| Opaleye Management Inc. | 600,000 | 600,000 | 0 | 0.67 | 0.53 | -0.14 | hold |
| ALGERT GLOBAL LLC | 538,939 | 592,309 | +53,370 | 0.07 | 0.07 | +0.00 | buy |
| Bank of New York Mellon Corp | 475,987 | 553,236 | +77,249 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 177,468 | 543,582 | +366,114 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 968,597 | 539,493 | -429,104 | 1.18 | 0.91 | -0.27 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 592,108 | 532,481 | -59,627 | 3.57 | 3.64 | +0.08 | sell |
| TUDOR INVESTMENT CORP ET AL | 614,378 | 522,663 | -91,715 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 397,092 | 519,231 | +122,139 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,744 | 484,120 | +333,376 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 520,663 | 482,293 | -38,370 | 0.00 | 0.00 | +0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 392,718 | 482,154 | +89,436 | 0.53 | 0.62 | +0.09 | buy |
| Principia Wealth Advisory, LLC | 408,700 | 440,618 | +31,918 | 1.96 | 2.16 | +0.21 | buy |
| BEACON INVESTMENT ADVISORS LLC | 430,876 | 435,131 | +4,255 | 1.38 | 1.34 | -0.04 | buy |
| BNP Paribas Asset Management Holding S.A. | 441,775 | 423,011 | -18,764 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 418,781 | +418,781 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 441,573 | 408,534 | -33,039 | 1.03 | 0.91 | -0.12 | sell |
| E. Ohman J:or Asset Management AB | 300,000 | 385,000 | +85,000 | 0.07 | 0.09 | +0.02 | buy |
| Rock Springs Capital Management LP | 383,716 | 383,716 | 0 | 0.19 | 0.18 | -0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,147,982 | 378,754 | -769,228 | 0.02 | 0.01 | -0.01 | sell |
| Propel Bio Management, LLC | 382,375 | 357,966 | -24,409 | 2.03 | 1.84 | -0.19 | sell |
| Jump Financial, LLC | 401,833 | 350,937 | -50,896 | 0.05 | 0.03 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 470,029 | 335,666 | -134,363 | 0.02 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 635,922 | 310,484 | -325,438 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 75,152 | 308,903 | +233,751 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 313,300 | 305,800 | -7,500 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 527,338 | 299,199 | -228,139 | 0.04 | 0.02 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 308,906 | 287,158 | -21,748 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 231,101 | 270,642 | +39,541 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 148,977 | 250,690 | +101,713 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 112,766 | 231,073 | +118,307 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 138,897 | 230,454 | +91,557 | 0.02 | 0.03 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 238,000 | 229,800 | -8,200 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 227,808 | 229,256 | +1,448 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 4,129,687 | 227,020 | -3,902,667 | 0.02 | 0.00 | -0.02 | sell |
| Rhenman & Partners Asset Management AB | 305,000 | 225,000 | -80,000 | 0.32 | 0.21 | -0.11 | sell |
| DEUTSCHE BANK AG\ | 631,741 | 224,145 | -407,596 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 220,000 | +220,000 | 0.00 | 0.04 | +0.04 | buy |
| SEI INVESTMENTS CO | 258,164 | 208,650 | -49,514 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 213,706 | 207,784 | -5,922 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 741,142 | 201,782 | -539,360 | 0.04 | 0.01 | -0.03 | sell |
| Russell Investments Group, Ltd. | 152,884 | 192,087 | +39,203 | 0.00 | 0.00 | +0.00 | buy |
| CSM Advisors, LLC | 0 | 190,194 | +190,194 | 0.00 | 0.04 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 188,368 | 188,368 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,632 | 186,356 | +53,724 | 0.03 | 0.03 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 181,588 | +181,588 | 0.00 | 1.10 | +1.10 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 165,984 | 169,064 | +3,080 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 89,267 | 165,142 | +75,875 | 0.00 | 0.01 | +0.00 | buy |
| Wealthspire Advisors, LLC | 0 | 162,960 | +162,960 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 121,951 | 161,460 | +39,509 | 0.09 | 0.13 | +0.04 | buy |
| WESBANCO BANK INC | 103,000 | 149,000 | +46,000 | 0.02 | 0.04 | +0.01 | buy |
| CITIGROUP INC | 55,777 | 140,718 | +84,941 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,555 | 136,256 | +130,701 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 740,803 | 126,033 | -614,770 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 218,478 | 124,457 | -94,021 | 0.00 | 0.00 | -0.00 | sell |
| TRUIST FINANCIAL CORP | 121,000 | 121,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 98,763 | 120,033 | +21,270 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 131,162 | 117,915 | -13,247 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 135,605 | 111,368 | -24,237 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 110,000 | 110,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| KRAEMATON INVESTMENT ADVISORS, INC | 97,617 | 109,967 | +12,350 | 0.67 | 0.80 | +0.13 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 111,005 | 109,826 | -1,179 | 0.00 | 0.00 | +0.00 | sell |