| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 5,780,000 | 6,468,000 | +688,000 | 7.13 | 6.61 | -0.53 | buy |
| SECTORAL ASSET MANAGEMENT INC | 802,680 | 969,350 | +166,670 | 0.69 | 0.59 | -0.10 | buy |
| GSA CAPITAL PARTNERS LLP | 118,953 | 233,582 | +114,629 | 0.07 | 0.07 | 0.00 | buy |
| DELTEC ASSET MANAGEMENT LLC | 1,974,797 | 2,061,797 | +87,000 | 2.23 | 1.47 | -0.75 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 302,111 | 342,111 | +40,000 | 0.06 | 0.03 | 0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 40,000 | 80,000 | +40,000 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,728 | 20,827 | +10,099 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,016 | 2,040 | +1,024 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF VERMONT | 4,000 | 5,000 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 32,500 | 22,500 | -10,000 | 0.02 | 0.01 | -0.01 | sell |
| EMERALD ADVISERS, LLC | 45,717 | 20,768 | -24,949 | 0.01 | 0.00 | -0.01 | sell |
| Ikarian Capital, LLC | 100,000 | 21,590 | -78,410 | 0.18 | 0.03 | -0.16 | sell |
| Knoll Capital Management, LLC | 200,000 | 400 | -199,600 | 1.26 | 0.00 | -1.26 | sell |