| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Assenagon Asset Management S.A. | 0 | 2,825,756 | +2,825,756 | 0.00 | 0.05 | +0.05 | buy |
| Artisan Partners Limited Partnership | 0 | 1,056,092 | +1,056,092 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 45,900 | 755,473 | +709,573 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 450,380 | 1,110,460 | +660,080 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,643,770 | 2,239,770 | +596,000 | 0.35 | 0.55 | +0.20 | buy |
| Polar Asset Management Partners Inc. | 0 | 492,900 | +492,900 | 0.00 | 0.10 | +0.10 | buy |
| Pale Fire Capital SE | 0 | 438,200 | +438,200 | 0.00 | 0.60 | +0.60 | buy |
| FMR LLC | 6,034 | 434,369 | +428,335 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,162,481 | 1,584,175 | +421,694 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 51,319 | 456,426 | +405,107 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 402,843 | +402,843 | 0.00 | 0.20 | +0.20 | buy |
| Knoll Capital Management, LLC | 200,400 | 600,400 | +400,000 | 0.92 | 2.42 | +1.50 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 264,355 | +264,355 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 0 | 235,498 | +235,498 | 0.00 | 0.76 | +0.76 | buy |
| CITADEL ADVISORS LLC | 4,053,862 | 4,259,838 | +205,976 | 0.03 | 0.04 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 88,051 | 273,633 | +185,582 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,079,277 | 1,246,697 | +167,420 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 314,554 | 462,864 | +148,310 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 373,081 | 511,522 | +138,441 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 750,000 | 885,000 | +135,000 | 4.06 | 5.11 | +1.05 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 126,681 | +126,681 | 0.00 | 0.08 | +0.08 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | 400,000 | +100,000 | 0.09 | 0.15 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 74,491 | +74,491 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 64,310 | 136,022 | +71,712 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 62,501 | +62,501 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,695,047 | 3,750,000 | +54,953 | 0.05 | 0.06 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 48,483 | +48,483 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 45,187 | +45,187 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 43,800 | +43,800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,572 | 85,610 | +27,038 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 807,310 | 833,574 | +26,264 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 23,246 | +23,246 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 22,649 | +22,649 | 0.00 | 0.05 | +0.05 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 21,416 | +21,416 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 0 | 20,947 | +20,947 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 63,975 | 82,858 | +18,883 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,488 | +17,488 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 25,049 | 38,601 | +13,552 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 116,964 | 130,202 | +13,238 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 36,543 | 49,072 | +12,529 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 12,239 | +12,239 | 0.00 | 0.00 | +0.00 | buy |
| SCOTIA CAPITAL INC. | 0 | 12,138 | +12,138 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,196 | 29,989 | +11,793 | 0.02 | 0.03 | +0.01 | buy |
| XPONANCE, INC. | 0 | 10,269 | +10,269 | 0.00 | 0.00 | +0.00 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,590,265 | 2,600,073 | +9,808 | 3.39 | 4.46 | +1.07 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 8,142 | +8,142 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 8,034 | +8,034 | 0.00 | 0.02 | +0.02 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 5,600 | +5,600 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 14,481 | 19,974 | +5,493 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 98,675 | 103,619 | +4,944 | 0.00 | 0.00 | +0.00 | buy |
| Golden State Equity Partners | 0 | 3,250 | +3,250 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 61,859 | 65,027 | +3,168 | 0.15 | 0.20 | +0.04 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,088 | 25,251 | +3,163 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 17,167 | 18,721 | +1,554 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 442,509 | 443,677 | +1,168 | 0.57 | 0.67 | +0.11 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,624 | 5,639 | +1,015 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 28,151 | 28,990 | +839 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 230 | +230 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10 | 198 | +188 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 407 | 593 | +186 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 638,665 | 638,847 | +182 | 0.01 | 0.02 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 70 | 170 | +100 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,170,163 | 1,170,256 | +93 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 67,651 | 67,693 | +42 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1 | 3 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 20,768 | 20,768 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 11,976 | 11,976 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 15,245 | 15,245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 112,800 | 112,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 162,820 | 162,820 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRUST CO OF VERMONT | 6,200 | 6,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 3,324,468 | 3,324,468 | 0 | 0.55 | 0.62 | +0.07 | hold |
| JANUS HENDERSON GROUP PLC | 53,500 | 53,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 8,040 | 8,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 90,000 | 90,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legato Capital Management LLC | 149,515 | 149,515 | 0 | 0.14 | 0.16 | +0.02 | hold |
| DekaBank Deutsche Girozentrale | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 90,280 | 90,280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 197,900 | 197,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 274 | 274 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hikari Power Ltd | 17,000 | 17,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 12,762,462 | 12,762,462 | 0 | 5.56 | 5.82 | +0.26 | hold |
| Avoro Capital Advisors LLC | 8,060,000 | 8,060,000 | 0 | 0.73 | 1.02 | +0.29 | hold |
| NewEdge Advisors, LLC | 1,480 | 1,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BEACON INVESTMENT ADVISORY SERVICES, INC. | 14,000 | 14,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Aptus Capital Advisors, LLC | 262,810 | 262,810 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Founders Capital Management | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Caption Management, LLC | 22,900 | 22,900 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 225 | 225 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IEQ CAPITAL, LLC | 17,629 | 17,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Relyea Zuckerberg Hanson LLC | 17,600 | 17,600 | 0 | 0.02 | 0.02 | +0.00 | hold |
| HighMark Wealth Management LLC | 397 | 397 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TFC Financial Management, Inc. | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Octagon Capital Advisors LP | 2,425,000 | 2,425,000 | 0 | 2.74 | 3.38 | +0.64 | hold |