| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,643,770 | 2,239,770 | +596,000 | 0.35 | 0.55 | +0.20 | buy |
| Knoll Capital Management, LLC | 200,400 | 600,400 | +400,000 | 0.92 | 2.42 | +1.50 | buy |
| Rosalind Advisors, Inc. | 750,000 | 885,000 | +135,000 | 3.95 | 4.93 | +0.98 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | 400,000 | +100,000 | 0.09 | 0.15 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,695,047 | 3,750,000 | +54,953 | 0.05 | 0.06 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 238,659 | 221,659 | +17,000 | 0.10 | 0.15 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,196 | 29,989 | +11,793 | 0.02 | 0.03 | +0.01 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,590,265 | 2,600,073 | +9,808 | 3.39 | 4.46 | +1.07 | buy |
| HighVista Strategies LLC | 61,859 | 65,027 | +3,168 | 0.15 | 0.20 | +0.04 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 442,509 | 443,677 | +1,168 | 0.57 | 0.67 | +0.11 | buy |
| Optiver Holding B.V. | 1,325 | 40 | -1,285 | 0.00 | 0.00 | -0.00 | sell |
| NOTTINGHAM ADVISORS, INC. | 193,266 | 185,766 | -7,500 | 0.16 | 0.18 | +0.02 | sell |
| Banco Santander, S.A. | 377,368 | 172,231 | -205,137 | 0.03 | 0.02 | -0.01 | sell |
| Opaleye Management Inc. | 5,307,500 | 5,025,000 | -282,500 | 8.29 | 7.29 | -1.00 | sell |
| Nantahala Capital Management, LLC | 1,000,000 | 700,000 | -300,000 | 0.40 | 0.31 | -0.09 | sell |
| SUMMER ROAD LLC | 14,885,633 | 14,398,193 | -487,440 | 98.54 | 98.66 | +0.12 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 2,771,130 | 1,190,071 | -1,581,059 | 15.96 | 8.39 | -7.58 | sell |
| Logos Global Management LP | 5,150,000 | 3,500,000 | -1,650,000 | 4.06 | 3.41 | -0.65 | sell |