| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 19,608,171 | 31,785,634 | +12,177,463 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 119,146 | 3,855,706 | +3,736,560 | 0.00 | 0.04 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 162,820 | 3,424,439 | +3,261,619 | 0.00 | 0.01 | +0.01 | buy |
| Avoro Capital Advisors LLC | 7,400,000 | 10,250,000 | +2,850,000 | 1.20 | 1.55 | +0.35 | buy |
| Point72 Asset Management, L.P. | 1,904,214 | 4,601,321 | +2,697,107 | 0.04 | 0.12 | +0.08 | buy |
| JANUS HENDERSON GROUP PLC | 53,500 | 2,048,500 | +1,995,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 218,293 | 2,189,276 | +1,970,983 | 0.00 | 0.05 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 1,601,449 | +1,601,449 | 0.00 | 0.02 | +0.02 | buy |
| Logos Global Management LP | 2,200,000 | 3,250,000 | +1,050,000 | 2.73 | 3.75 | +1.03 | buy |
| Woodline Partners LP | 750,950 | 1,666,087 | +915,137 | 0.04 | 0.09 | +0.05 | buy |
| CITADEL ADVISORS LLC | 4,886,014 | 5,703,781 | +817,767 | 0.04 | 0.05 | +0.01 | buy |
| TCG Crossover Management, LLC | 5,319,148 | 6,117,232 | +798,084 | 5.64 | 3.52 | -2.12 | buy |
| VANGUARD GROUP INC | 8,392,175 | 9,163,240 | +771,065 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 598,000 | +598,000 | 0.00 | 0.11 | +0.11 | buy |
| CITIGROUP INC | 99,844 | 673,348 | +573,504 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 518,754 | +518,754 | 0.00 | 0.04 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 0 | 466,179 | +466,179 | 0.00 | 0.08 | +0.08 | buy |
| Saturn V Capital Management LP | 728,576 | 1,151,686 | +423,110 | 2.74 | 2.95 | +0.21 | buy |
| VR Adviser, LLC | 12,762,462 | 13,161,462 | +399,000 | 8.88 | 8.66 | -0.22 | buy |
| STEMPOINT CAPITAL LP | 0 | 359,470 | +359,470 | 0.00 | 0.85 | +0.85 | buy |
| Squarepoint Ops LLC | 0 | 350,758 | +350,758 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 339,631 | +339,631 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 322,914 | +322,914 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 232,886 | 555,145 | +322,259 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.21 | +0.21 | buy |
| Empire Life Investments Inc. | 0 | 251,262 | +251,262 | 0.00 | 0.17 | +0.17 | buy |
| Centiva Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.27 | +0.27 | buy |
| JANE STREET GROUP, LLC | 110,472 | 353,812 | +243,340 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 239,000 | +239,000 | 0.00 | 0.26 | +0.26 | buy |
| Rhenman & Partners Asset Management AB | 0 | 202,000 | +202,000 | 0.00 | 0.26 | +0.26 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 201,865 | +201,865 | 0.00 | 0.05 | +0.05 | buy |
| Octagon Capital Advisors LP | 2,425,000 | 2,624,000 | +199,000 | 4.94 | 4.79 | -0.15 | buy |
| GOLDMAN SACHS GROUP INC | 605,165 | 795,968 | +190,803 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 187,782 | +187,782 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 163,132 | +163,132 | 0.00 | 0.03 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 161,899 | +161,899 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 1,014,940 | 1,165,206 | +150,266 | 13.15 | 14.08 | +0.93 | buy |
| Artia Global Partners LP | 0 | 141,061 | +141,061 | 0.00 | 0.29 | +0.29 | buy |
| RAYMOND JAMES FINANCIAL INC | 884,381 | 1,011,969 | +127,588 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 110,832 | 234,213 | +123,381 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 115,553 | +115,553 | 0.00 | 0.11 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,890,177 | 4,004,350 | +114,173 | 0.06 | 0.07 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 113,900 | +113,900 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| Shay Capital LLC | 0 | 84,500 | +84,500 | 0.00 | 0.18 | +0.18 | buy |
| Brevan Howard Capital Management LP | 32,328 | 109,945 | +77,617 | 0.00 | 0.02 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 3,420,340 | 3,497,307 | +76,967 | 1.36 | 1.21 | -0.15 | buy |
| DEUTSCHE BANK AG\ | 240,021 | 312,082 | +72,061 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 62,846 | +62,846 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 0 | 62,224 | +62,224 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 60,841 | +60,841 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 74,150 | 130,852 | +56,702 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,284,171 | 3,338,453 | +54,282 | 0.00 | 0.00 | +0.00 | buy |
| HARBERT FUND ADVISORS, INC. | 0 | 50,000 | +50,000 | 0.00 | 3.81 | +3.81 | buy |
| SG Americas Securities, LLC | 10,435 | 55,496 | +45,061 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 37,331 | +37,331 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 111,022 | 145,876 | +34,854 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 34,433 | +34,433 | 0.00 | 0.02 | +0.02 | buy |
| Voleon Capital Management LP | 0 | 33,203 | +33,203 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 30,852 | +30,852 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 30,415 | +30,415 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 20,196 | 50,603 | +30,407 | 0.02 | 0.04 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,095,455 | 1,124,103 | +28,648 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,259 | +27,259 | 0.00 | 0.00 | +0.00 | buy |
| Union Bancaire Privee, UBP SA | 0 | 25,500 | +25,500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 7,811 | 32,643 | +24,832 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,156,258 | 1,175,334 | +19,076 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 382,309 | 400,773 | +18,464 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 88,876 | 106,611 | +17,735 | 0.30 | 0.31 | +0.00 | buy |
| Verition Fund Management LLC | 148,602 | 166,033 | +17,431 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 0 | 17,269 | +17,269 | 0.00 | 0.07 | +0.07 | buy |
| Aptus Capital Advisors, LLC | 385,467 | 402,467 | +17,000 | 0.04 | 0.04 | +0.01 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 17,000 | +17,000 | 0.00 | 0.20 | +0.20 | buy |
| Second Line Capital, LLC | 385,467 | 402,467 | +17,000 | 0.83 | 0.97 | +0.14 | buy |
| RWC Asset Management LLP | 0 | 16,241 | +16,241 | 0.00 | 0.01 | +0.01 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 0 | 13,823 | +13,823 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 381,595 | 394,076 | +12,481 | 0.64 | 0.71 | +0.06 | buy |
| Virtu Financial LLC | 0 | 11,510 | +11,510 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 98,097 | 109,372 | +11,275 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 11,263 | +11,263 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,383 | 100,264 | +10,881 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 10,760 | +10,760 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 10,546,379 | 10,556,837 | +10,458 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 102,833 | 113,279 | +10,446 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 1,065,969 | 1,076,382 | +10,413 | 0.01 | 0.02 | +0.00 | buy |
| Cetera Investment Advisers | 705,406 | 714,066 | +8,660 | 0.01 | 0.01 | -0.00 | buy |
| Quarry LP | 0 | 6,870 | +6,870 | 0.00 | 0.02 | +0.02 | buy |
| Police & Firemen's Retirement System of New Jersey | 32,383 | 38,921 | +6,538 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 5,825 | +5,825 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 126,366 | 131,564 | +5,198 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 24,100 | 29,100 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 27,185 | 31,914 | +4,729 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 391,754 | 395,519 | +3,765 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 197,400 | 200,700 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 13,413 | 16,571 | +3,158 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 21,410 | 24,535 | +3,125 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,906 | 25,178 | +2,272 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,944 | 16,784 | +840 | 0.00 | 0.00 | +0.00 | buy |