| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 19,608,171 | 31,785,634 | +12,177,463 | 0.01 | 0.02 | +0.01 | buy |
| VR Adviser, LLC | 12,762,462 | 13,161,462 | +399,000 | 8.88 | 8.66 | -0.22 | buy |
| SUMMER ROAD LLC | 13,887,468 | 12,579,657 | -1,307,811 | 98.23 | 98.57 | +0.34 | sell |
| Deep Track Capital, LP | 14,294,420 | 11,932,137 | -2,362,283 | 4.26 | 3.89 | -0.37 | sell |
| BlackRock, Inc. | 10,546,379 | 10,556,837 | +10,458 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 7,400,000 | 10,250,000 | +2,850,000 | 1.20 | 1.55 | +0.35 | buy |
| VANGUARD GROUP INC | 8,392,175 | 9,163,240 | +771,065 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 5,319,148 | 6,117,232 | +798,084 | 5.64 | 3.52 | -2.12 | buy |
| CITADEL ADVISORS LLC | 4,886,014 | 5,703,781 | +817,767 | 0.04 | 0.05 | +0.01 | buy |
| Point72 Asset Management, L.P. | 1,904,214 | 4,601,321 | +2,697,107 | 0.04 | 0.12 | +0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,890,177 | 4,004,350 | +114,173 | 0.06 | 0.07 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 119,146 | 3,855,706 | +3,736,560 | 0.00 | 0.04 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 3,420,340 | 3,497,307 | +76,967 | 1.36 | 1.21 | -0.15 | buy |
| STATE STREET CORP | 3,509,110 | 3,460,012 | -49,098 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 162,820 | 3,424,439 | +3,261,619 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,284,171 | 3,338,453 | +54,282 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 2,200,000 | 3,250,000 | +1,050,000 | 2.73 | 3.75 | +1.03 | buy |
| DELTEC ASSET MANAGEMENT LLC | 2,794,892 | 2,762,459 | -32,433 | 4.62 | 5.33 | +0.70 | sell |
| Octagon Capital Advisors LP | 2,425,000 | 2,624,000 | +199,000 | 4.94 | 4.79 | -0.15 | buy |
| MORGAN STANLEY | 2,571,723 | 2,465,676 | -106,047 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 218,293 | 2,189,276 | +1,970,983 | 0.00 | 0.05 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 53,500 | 2,048,500 | +1,995,000 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 750,950 | 1,666,087 | +915,137 | 0.04 | 0.09 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 1,601,449 | +1,601,449 | 0.00 | 0.02 | +0.02 | buy |
| Opaleye Management Inc. | 1,595,000 | 1,595,000 | 0 | 3.00 | 2.64 | -0.36 | hold |
| UBS Group AG | 1,965,151 | 1,248,266 | -716,885 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,156,258 | 1,175,334 | +19,076 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 1,014,940 | 1,165,206 | +150,266 | 13.15 | 14.08 | +0.93 | buy |
| Saturn V Capital Management LP | 728,576 | 1,151,686 | +423,110 | 2.74 | 2.95 | +0.21 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,095,455 | 1,124,103 | +28,648 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 1,065,969 | 1,076,382 | +10,413 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 1,538,846 | 1,043,896 | -494,950 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 884,381 | 1,011,969 | +127,588 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 605,165 | 795,968 | +190,803 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 817,699 | 715,000 | -102,699 | 2.74 | 2.24 | -0.50 | sell |
| Cetera Investment Advisers | 705,406 | 714,066 | +8,660 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 99,844 | 673,348 | +573,504 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,788,603 | 638,952 | -1,149,651 | 0.03 | 0.01 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 861,962 | 617,519 | -244,443 | 0.24 | 0.22 | -0.02 | sell |
| Knoll Capital Management, LLC | 600,400 | 600,400 | 0 | 1.32 | 3.76 | +2.44 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 598,000 | +598,000 | 0.00 | 0.11 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 232,886 | 555,145 | +322,259 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 518,754 | +518,754 | 0.00 | 0.04 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 0 | 466,179 | +466,179 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 759,260 | 447,116 | -312,144 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 496,030 | 411,617 | -84,413 | 0.00 | 0.00 | -0.00 | sell |
| Aptus Capital Advisors, LLC | 385,467 | 402,467 | +17,000 | 0.04 | 0.04 | +0.01 | buy |
| Second Line Capital, LLC | 385,467 | 402,467 | +17,000 | 0.83 | 0.97 | +0.14 | buy |
| Bank of New York Mellon Corp | 382,309 | 400,773 | +18,464 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 1,218,700 | 400,000 | -818,700 | 5.47 | 1.65 | -3.82 | sell |
| ROYAL BANK OF CANADA | 391,754 | 395,519 | +3,765 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 381,595 | 394,076 | +12,481 | 0.64 | 0.71 | +0.06 | buy |
| STEMPOINT CAPITAL LP | 0 | 359,470 | +359,470 | 0.00 | 0.85 | +0.85 | buy |
| JANE STREET GROUP, LLC | 110,472 | 353,812 | +243,340 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 350,758 | +350,758 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 362,310 | 345,361 | -16,949 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 339,631 | +339,631 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 322,914 | +322,914 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 240,021 | 312,082 | +72,061 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.21 | +0.21 | buy |
| JPMORGAN CHASE & CO | 712,100 | 276,160 | -435,940 | 0.00 | 0.00 | -0.00 | sell |
| Empire Life Investments Inc. | 0 | 251,262 | +251,262 | 0.00 | 0.17 | +0.17 | buy |
| Centiva Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.27 | +0.27 | buy |
| Affinity Asset Advisors, LLC | 0 | 239,000 | +239,000 | 0.00 | 0.26 | +0.26 | buy |
| Erste Asset Management GmbH | 235,800 | 235,800 | 0 | 0.02 | 0.03 | +0.01 | hold |
| TWO SIGMA INVESTMENTS, LP | 110,832 | 234,213 | +123,381 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 225,548 | 220,008 | -5,540 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 0 | 202,000 | +202,000 | 0.00 | 0.26 | +0.26 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 201,865 | +201,865 | 0.00 | 0.05 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 316,276 | 201,259 | -115,017 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 197,400 | 200,700 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 187,782 | +187,782 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 291,570 | 184,427 | -107,143 | 0.00 | 0.00 | -0.00 | sell |
| RoundAngle Advisors LLC | 185,706 | 176,800 | -8,906 | 1.44 | 1.60 | +0.16 | sell |
| MACQUARIE GROUP LTD | 242,039 | 174,389 | -67,650 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 148,602 | 166,033 | +17,431 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 163,132 | +163,132 | 0.00 | 0.03 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 161,899 | +161,899 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 111,022 | 145,876 | +34,854 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 141,061 | +141,061 | 0.00 | 0.29 | +0.29 | buy |
| COURIER CAPITAL LLC | 154,266 | 136,266 | -18,000 | 0.09 | 0.09 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 126,366 | 131,564 | +5,198 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 74,150 | 130,852 | +56,702 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 126,681 | 125,194 | -1,487 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 153,670 | 116,114 | -37,556 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 115,553 | +115,553 | 0.00 | 0.11 | +0.11 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 113,900 | +113,900 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 102,833 | 113,279 | +10,446 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 112,820 | 112,820 | 0 | 0.12 | 0.14 | +0.02 | hold |
| Brevan Howard Capital Management LP | 32,328 | 109,945 | +77,617 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 98,097 | 109,372 | +11,275 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 88,876 | 106,611 | +17,735 | 0.30 | 0.31 | +0.00 | buy |
| Legal & General Group Plc | 104,853 | 104,328 | -525 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,383 | 100,264 | +10,881 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Maven Securities LTD | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| TRUIST FINANCIAL CORP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 90,000 | 90,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Shay Capital LLC | 0 | 84,500 | +84,500 | 0.00 | 0.18 | +0.18 | buy |
| MetLife Investment Management, LLC | 84,066 | 84,066 | 0 | 0.00 | 0.00 | +0.00 | hold |