| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 31,785,634 | 31,785,605 | -29 | 0.02 | 0.02 | +0.00 | sell |
| BlackRock, Inc. | 10,556,837 | 15,602,394 | +5,045,557 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 9,163,240 | 11,575,193 | +2,411,953 | 0.00 | 0.00 | +0.00 | buy |
| SUMMER ROAD LLC | 12,579,657 | 11,108,555 | -1,471,102 | 98.57 | 97.92 | -0.65 | sell |
| Avoro Capital Advisors LLC | 10,250,000 | 10,777,777 | +527,777 | 1.55 | 1.29 | -0.26 | buy |
| Deep Track Capital, LP | 11,932,137 | 8,070,414 | -3,861,723 | 3.89 | 2.23 | -1.66 | sell |
| VR Adviser, LLC | 13,161,462 | 7,315,547 | -5,845,915 | 8.66 | 4.39 | -4.27 | sell |
| TCG Crossover Management, LLC | 6,117,232 | 5,740,231 | -377,001 | 3.52 | 2.31 | -1.21 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,004,350 | 4,625,050 | +620,700 | 0.07 | 0.08 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,338,453 | 4,356,547 | +1,018,094 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 3,424,439 | 4,341,951 | +917,512 | 0.01 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,048,500 | 4,229,202 | +2,180,702 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 3,460,012 | 4,196,330 | +736,318 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 3,250,000 | 3,500,000 | +250,000 | 3.75 | 2.83 | -0.92 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,855,706 | 3,207,881 | -647,825 | 0.04 | 0.03 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 3,497,307 | 2,935,284 | -562,023 | 1.21 | 0.95 | -0.26 | sell |
| Octagon Capital Advisors LP | 2,624,000 | 2,623,600 | -400 | 4.79 | 3.99 | -0.80 | sell |
| DELTEC ASSET MANAGEMENT LLC | 2,762,459 | 2,487,934 | -274,525 | 5.33 | 5.00 | -0.32 | sell |
| CITADEL ADVISORS LLC | 5,703,781 | 2,475,849 | -3,227,932 | 0.05 | 0.02 | -0.03 | sell |
| Woodline Partners LP | 1,666,087 | 1,666,136 | +49 | 0.09 | 0.08 | -0.01 | buy |
| Opaleye Management Inc. | 1,595,000 | 1,595,000 | 0 | 2.64 | 2.55 | -0.08 | hold |
| GOLDMAN SACHS GROUP INC | 795,968 | 1,547,523 | +751,555 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 1,151,686 | 1,504,880 | +353,194 | 2.95 | 3.35 | +0.40 | buy |
| NORTHERN TRUST CORP | 1,175,334 | 1,462,503 | +287,169 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,124,103 | 1,460,457 | +336,354 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,601,449 | 1,377,203 | -224,246 | 0.02 | 0.02 | -0.00 | sell |
| UBS Group AG | 1,248,266 | 1,244,944 | -3,322 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 113,279 | 1,153,910 | +1,040,631 | 0.00 | 0.01 | +0.01 | buy |
| Artisan Partners Limited Partnership | 1,076,382 | 1,063,371 | -13,011 | 0.02 | 0.02 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 1,165,206 | 1,052,995 | -112,211 | 14.08 | 8.68 | -5.40 | sell |
| JANE STREET GROUP, LLC | 353,812 | 1,034,229 | +680,417 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 4,601,321 | 1,016,248 | -3,585,073 | 0.12 | 0.02 | -0.10 | sell |
| Invesco Ltd. | 1,043,896 | 895,687 | -148,209 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,465,676 | 879,144 | -1,586,532 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 411,617 | 857,649 | +446,032 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,011,969 | 842,187 | -169,782 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 0 | 841,602 | +841,602 | 0.00 | 0.05 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 812,078 | +812,078 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 791,200 | +791,200 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 30,852 | 769,774 | +738,922 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,189,276 | 763,559 | -1,425,717 | 0.05 | 0.02 | -0.03 | sell |
| Cetera Investment Advisers | 714,066 | 722,540 | +8,474 | 0.01 | 0.01 | -0.00 | buy |
| Catalio Capital Management, LP | 0 | 714,501 | +714,501 | 0.00 | 1.53 | +1.53 | buy |
| Assenagon Asset Management S.A. | 45,600 | 620,814 | +575,214 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 673,348 | 601,917 | -71,431 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 447,116 | 601,360 | +154,244 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 600,400 | 600,400 | 0 | 3.76 | 3.34 | -0.42 | hold |
| Trexquant Investment LP | 187,782 | 592,877 | +405,095 | 0.02 | 0.06 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 312,082 | 590,721 | +278,639 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 617,519 | 571,103 | -46,416 | 0.22 | 0.21 | -0.00 | sell |
| JPMORGAN CHASE & CO | 276,160 | 550,269 | +274,109 | 0.00 | 0.00 | +0.00 | buy |
| Empire Life Investments Inc. | 251,262 | 540,115 | +288,853 | 0.17 | 0.37 | +0.20 | buy |
| STEMPOINT CAPITAL LP | 359,470 | 522,693 | +163,223 | 0.85 | 1.09 | +0.24 | buy |
| Aptus Capital Advisors, LLC | 402,467 | 500,752 | +98,285 | 0.04 | 0.05 | +0.01 | buy |
| Second Line Capital, LLC | 402,467 | 500,746 | +98,279 | 0.97 | 1.25 | +0.28 | buy |
| TUDOR INVESTMENT CORP ET AL | 161,899 | 494,792 | +332,893 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 400,773 | 490,278 | +89,505 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 715,000 | 490,000 | -225,000 | 2.24 | 1.27 | -0.96 | sell |
| Nuveen, LLC | 345,361 | 462,807 | +117,446 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 991 | 445,405 | +444,414 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 350,758 | 440,437 | +89,679 | 0.01 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 418,080 | +418,080 | 0.00 | 2.72 | +2.72 | buy |
| HRT FINANCIAL LP | 322,914 | 402,963 | +80,049 | 0.01 | 0.02 | +0.00 | buy |
| Rosalind Advisors, Inc. | 400,000 | 400,000 | 0 | 1.65 | 1.77 | +0.12 | hold |
| AMERIPRISE FINANCIAL INC | 555,145 | 395,591 | -159,554 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 395,335 | +395,335 | 0.00 | 0.11 | +0.11 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 394,076 | 385,825 | -8,251 | 0.71 | 0.71 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 234,213 | 380,713 | +146,500 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 300,000 | 345,820 | +45,820 | 0.21 | 0.22 | +0.01 | buy |
| HighVista Strategies LLC | 106,611 | 344,067 | +237,456 | 0.31 | 1.08 | +0.77 | buy |
| Swiss National Bank | 200,700 | 313,300 | +112,600 | 0.00 | 0.00 | +0.00 | buy |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 0 | 313,000 | +313,000 | 0.00 | 0.35 | +0.35 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 201,259 | 307,747 | +106,488 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 109,945 | 305,815 | +195,870 | 0.02 | 0.07 | +0.05 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 293,263 | +293,263 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 339,631 | 268,694 | -70,937 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 202,000 | 265,000 | +63,000 | 0.26 | 0.30 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 29,495 | 255,921 | +226,426 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 130,852 | 255,222 | +124,370 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 220,008 | 241,321 | +21,313 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 60,841 | 230,509 | +169,668 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 145,876 | 180,723 | +34,847 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 62,224 | 173,793 | +111,569 | 0.01 | 0.03 | +0.02 | buy |
| Verition Fund Management LLC | 166,033 | 171,606 | +5,573 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 131,564 | 171,524 | +39,960 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 116,114 | 169,673 | +53,559 | 0.00 | 0.00 | +0.00 | buy |
| RoundAngle Advisors LLC | 176,800 | 168,854 | -7,946 | 1.60 | 1.49 | -0.11 | sell |
| BEACON INVESTMENT ADVISORS LLC | 0 | 165,556 | +165,556 | 0.00 | 0.81 | +0.81 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 125,194 | 162,810 | +37,616 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 160,389 | +160,389 | 0.00 | 0.31 | +0.31 | buy |
| Legal & General Group Plc | 104,328 | 157,336 | +53,008 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 157,300 | +157,300 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 27,259 | 154,969 | +127,710 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 100,264 | 150,701 | +50,437 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 113,900 | 142,924 | +29,024 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 141,061 | 141,061 | 0 | 0.29 | 0.28 | -0.02 | hold |
| TWINBEECH CAPITAL LP | 62,846 | 140,350 | +77,504 | 0.03 | 0.12 | +0.09 | buy |
| ALGERT GLOBAL LLC | 0 | 127,410 | +127,410 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 109,372 | 124,672 | +15,300 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 112,820 | 123,649 | +10,829 | 0.14 | 0.13 | -0.01 | buy |