| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,004,350 | 4,625,050 | +620,700 | 0.07 | 0.08 | +0.01 | buy |
| Avoro Capital Advisors LLC | 10,250,000 | 10,777,777 | +527,777 | 1.55 | 1.29 | -0.26 | buy |
| Saturn V Capital Management LP | 1,151,686 | 1,504,880 | +353,194 | 2.95 | 3.35 | +0.40 | buy |
| Empire Life Investments Inc. | 251,262 | 540,115 | +288,853 | 0.17 | 0.37 | +0.20 | buy |
| Logos Global Management LP | 3,250,000 | 3,500,000 | +250,000 | 3.75 | 2.83 | -0.92 | buy |
| HighVista Strategies LLC | 106,611 | 344,067 | +237,456 | 0.31 | 1.08 | +0.77 | buy |
| STEMPOINT CAPITAL LP | 359,470 | 522,693 | +163,223 | 0.85 | 1.09 | +0.24 | buy |
| Second Line Capital, LLC | 402,467 | 500,746 | +98,279 | 0.97 | 1.25 | +0.28 | buy |
| GSA CAPITAL PARTNERS LLP | 115,553 | 35,098 | +80,455 | 0.13 | 0.04 | 0.00 | sell |
| TWINBEECH CAPITAL LP | 62,846 | 140,350 | +77,504 | 0.03 | 0.12 | +0.09 | buy |
| Rhenman & Partners Asset Management AB | 202,000 | 265,000 | +63,000 | 0.26 | 0.30 | +0.04 | buy |
| Rock Springs Capital Management LP | 300,000 | 345,820 | +45,820 | 0.20 | 0.22 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 83,439 | 105,627 | +22,188 | 0.04 | 0.06 | +0.02 | buy |
| Legato Capital Management LLC | 112,820 | 123,649 | +10,829 | 0.14 | 0.13 | -0.01 | buy |
| Scientech Research LLC | 17,269 | 26,286 | +9,017 | 0.07 | 0.20 | +0.13 | buy |
| TRUST CO OF VERMONT | 7,200 | 8,950 | +1,750 | 0.00 | 0.00 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,743 | 4,185 | +442 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 716 | 1,092 | +376 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 2,328 | 1,949 | -379 | 0.01 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 2,624,000 | 2,623,600 | -400 | 4.79 | 3.99 | -0.80 | sell |
| RWC Asset Management LLP | 16,241 | 14,797 | -1,444 | 0.01 | 0.01 | -0.00 | sell |
| FIFTH LANE CAPITAL, LP | 17,000 | 14,358 | -2,642 | 0.20 | 0.21 | +0.01 | sell |
| Union Bancaire Privee, UBP SA | 25,500 | 22,000 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| RoundAngle Advisors LLC | 176,800 | 168,854 | -7,946 | 1.60 | 1.49 | -0.11 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 394,076 | 385,825 | -8,251 | 0.71 | 0.71 | +0.01 | sell |
| Voleon Capital Management LP | 33,203 | 21,822 | -11,381 | 0.01 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 1,076,382 | 1,063,371 | -13,011 | 0.02 | 0.02 | +0.00 | sell |
| Shay Capital LLC | 84,500 | 63,000 | -21,500 | 0.18 | 0.12 | -0.06 | sell |
| China Universal Asset Management Co., Ltd. | 60,499 | 35,716 | -24,783 | 0.06 | 0.03 | -0.03 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 617,519 | 571,103 | -46,416 | 0.22 | 0.21 | -0.00 | sell |
| COURIER CAPITAL LLC | 136,266 | 70,104 | -66,162 | 0.09 | 0.05 | -0.04 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 1,165,206 | 1,052,995 | -112,211 | 14.08 | 8.68 | -5.40 | sell |
| Erste Asset Management GmbH | 235,800 | 110,000 | -125,800 | 0.03 | 0.01 | -0.02 | sell |
| Patient Square Capital LP | 715,000 | 490,000 | -225,000 | 2.24 | 1.27 | -0.96 | sell |
| DELTEC ASSET MANAGEMENT LLC | 2,762,459 | 2,487,934 | -274,525 | 5.33 | 5.00 | -0.32 | sell |
| TCG Crossover Management, LLC | 6,117,232 | 5,740,231 | -377,001 | 3.52 | 2.31 | -1.21 | sell |
| Paradigm Biocapital Advisors LP | 3,497,307 | 2,935,284 | -562,023 | 1.21 | 0.95 | -0.26 | sell |
| SUMMER ROAD LLC | 12,579,657 | 11,108,555 | -1,471,102 | 98.57 | 97.92 | -0.65 | sell |
| Deep Track Capital, LP | 11,932,137 | 8,070,414 | -3,861,723 | 3.89 | 2.23 | -1.66 | sell |
| VR Adviser, LLC | 13,161,462 | 7,315,547 | -5,845,915 | 8.66 | 4.39 | -4.27 | sell |